Slc2a10 solute carrier family 2 (facilitated glucose transporter), member 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc2a10provided by MGI
Official Full Name: solute carrier family 2 (facilitated glucose transporter), member 10provided by MGI
Primary source: MGI:MGI:2156687
See related: Ensembl:ENSMUSG00000027661 AllianceGenome:MGI:2156687
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Glut10
Summary: This gene encodes a class III facilitative glucose transporter. Mutations in the related gene in human are associated with arterial tortuosity syndrome. [provided by RefSeq, Dec 2013]
Expression: Biased expression in stomach adult (RPKM 17.5), colon adult (RPKM 9.3) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 85.66 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (165345817..165361837)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (165503897..165519917)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glut10 restrains neointima formation by promoting SMCs mtDNA demethylation and improving mitochondrial function.
Title: Glut10 restrains neointima formation by promoting SMCs mtDNA demethylation and improving mitochondrial function.
Mustn1 ablation in skeletal muscle results in increased glucose tolerance concomitant with upregulated GLUT expression in male mice.
Title: Mustn1 ablation in skeletal muscle results in increased glucose tolerance concomitant with upregulated GLUT expression in male mice.
Slc2a10 knock-out mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects.
Title: Slc2a10 knock-out mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects.
Data show that GLUT10 regulates adipogenesis via ascorbic acid-dependent DNA demethylation to benefit proper white adipose tissue development and protect mice against high-fat diet (HFD)-induced metabolic dysregulation. These findings suggest that SLC2A10 may be an important HFD-associated susceptibility locus for type 2 diabetes mellitus.
Title: Glucose transporter 10 modulates adipogenesis via an ascorbic acid-mediated pathway to protect mice against diet-induced metabolic dysregulation.
Glut10 may contribute to glucose transport from the endolymph to the hair cells across the cuticular plate in the mouse inner ear
Title: Localization of Glucose Transporter 10 to Hair Cells' Cuticular Plate in the Mouse Inner Ear.
GLUT10 protects cells from oxidative injury.
Title: Mitochondrial GLUT10 facilitates dehydroascorbic acid import and protects cells against oxidative stress: mechanistic insight into arterial tortuosity syndrome.
report that two mouse models, homozygous respectively for G128E and S150F missense substitutions in glut10 do not present any of the vascular, anatomical, or immunohistological abnormalities as encountered in human Arterial tortuosity syndrome patients.
Title: Absence of arterial phenotype in mice with homozygous slc2A10 missense substitutions.
expression in adipose tissue
Title: Expression of Class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

D2Mit289 (e-PCR), detects polymorphism
- UniSTS:129175

Slc2a10 (e-PCR), detects polymorphism
- UniSTS:547071

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables dehydroascorbic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within artery development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within carbohydrate transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell redox homeostasis	ISO Inferred from Sequence Orthology more info
involved_in circulatory system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in dehydroascorbic acid transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal joint development	ISO Inferred from Sequence Orthology more info
involved_in glucose import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in glucose transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glucose transmembrane transport	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of connective tissue growth factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of extracellular matrix organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 10

Names: glucose transporter type 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130451.3 → NP_569718.1 solute carrier family 2, facilitated glucose transporter member 10

See identical proteins and their annotated locations for NP_569718.1

Status: REVIEWED

Source sequence(s)

AK052156, BB732254, BY230011

Consensus CDS

CCDS17083.1

UniProtKB/Swiss-Prot

Q8VHD6

UniProtKB/TrEMBL

A2A4V1

Related

ENSMUSP00000029196.5, ENSMUST00000029196.5

Conserved Domains (2) summary

cd06174
Location:14 → 323

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:11 → 508

Sugar_tr; Sugar (and other) transporter