Lrpap1 low density lipoprotein receptor-related protein associated protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrpap1provided by MGI
Official Full Name: low density lipoprotein receptor-related protein associated protein 1provided by MGI
Primary source: MGI:MGI:96829
See related: Ensembl:ENSMUSG00000029103 AllianceGenome:MGI:96829
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RAP; HBP44
Summary: Enables low-density lipoprotein particle receptor binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; negative regulation of amyloid-beta clearance; and negative regulation of very-low-density lipoprotein particle clearance. Predicted to be located in Golgi apparatus; rough endoplasmic reticulum; and vesicle. Predicted to be active in several cellular components, including cis-Golgi network; endoplasmic reticulum-Golgi intermediate compartment; and rough endoplasmic reticulum lumen. Is expressed in several structures, including central nervous system; egg cylinder; foregut; genitourinary system; and lung. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 78.1), placenta adult (RPKM 64.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B2; 5 18.01 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (35248834..35263043, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (35091490..35105699, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation.
Title: LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation.
Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity.
Title: Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity.
Involvement of chronic unpredictable mild stress-induced hippocampal LRP1 up-regulation in microtubule instability and depressive-like behavior in a depressive-like adult male rat model.
Title: Involvement of chronic unpredictable mild stress-induced hippocampal LRP1 up-regulation in microtubule instability and depressive-like behavior in a depressive-like adult male rat model.
RAP deficiency attenuated atherosclerosis without influencing abdominal aortic aneurysms in hypercholesterolemic mice infused with angiotensin II.
Title: Deficiency of receptor-associated protein attenuates angiotensin II-induced atherosclerosis in hypercholesterolemic mice without influencing abdominal aortic aneurysms.
Findings reveal that RAP is a novel Abeta-binding protein that promotes cellular internalization of Abeta.
Title: Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake.
Receptor-associated protein (RAP) plays a central role in modulating Abeta deposition in APP/PS1 transgenic mice
Title: Receptor-associated protein (RAP) plays a central role in modulating Abeta deposition in APP/PS1 transgenic mice.
Disruption of the RAP gene determines not only thyroid abnormalities, but also a severe defect of megalin expression and function in the kidney.
Title: Kidney abnormalities in low density lipoprotein receptor associated protein knockout mice.
Results suggest that receptor-associated protein is required for the establishment of thyroglobulin reservoirs, but its absence does not affect hormone secretion.
Title: Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice.
the His-sRAP-induced acceleration of megalin-mediated endocytosis causes phosphaturia via altered subcellular distribution of NaPi-II [39-kD receptor-associated protein (RAP)]
Title: Intraperitoneal administration of recombinant receptor-associated protein causes phosphaturia via an alteration in subcellular distribution of the renal sodium phosphate co-transporter.
RAP is expressed by thyrocytes in a TSH-dependent manner, both in cultured thyroid cells and in vivo
Title: TSH-Dependent expression of the LDL receptor-associated protein (RAP) in thyroid epithelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D00622 (e-PCR)
- UniSTS:124724

RH124258 (e-PCR)
- UniSTS:161080

AU042172 (e-PCR)
- UniSTS:159363

RH126240 (e-PCR)
- UniSTS:162948

AI790446 (e-PCR)
- UniSTS:179156

LRPAP1 (e-PCR)
- UniSTS:519166

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables lipase binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipase binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
enables receptor antagonist activity	IBA Inferred from Biological aspect of Ancestor more info
enables receptor antagonist activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables very-low-density lipoprotein particle receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables very-low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid-beta clearance by transcytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of very-low-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of very-low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cis-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in rough endoplasmic reticulum lumen	IBA Inferred from Biological aspect of Ancestor more info
located_in rough endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-2-macroglobulin receptor-associated protein

Names: alpha-2-MRAP; alpha-2-macroglobulin receptor-associated protein precursor (alpha-2-MRAP); heparin-binding protein 44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013587.3 → NP_038615.2 alpha-2-macroglobulin receptor-associated protein precursor

See identical proteins and their annotated locations for NP_038615.2

Status: VALIDATED

Source sequence(s)

BC094324, BY642418, BY771772

Consensus CDS

CCDS19225.1

UniProtKB/Swiss-Prot

P55302

UniProtKB/TrEMBL

Q3TL96, Q52KI7, Q5D0B0, Q6ZY49, Q8C252

Related

ENSMUSP00000030986.9, ENSMUST00000030986.15

Conserved Domains (5) summary

cd14806
Location:61 → 70

RAP_D1; 3-helical coiled coil [structural motif]

cd14807
Location:149 → 246

RAP_D2; Domain 2 of receptor-associated protein (RAP)

cd14808
Location:255 → 360

RAP_D3; C-terminal receptor-associated protein (RAP), Domain 3

pfam06400
Location:31 → 134

Alpha-2-MRAP_N; Alpha-2-macroglobulin RAP, N-terminal domain

pfam06401
Location:149 → 360

Alpha-2-MRAP_C; Alpha-2-macroglobulin RAP, C-terminal domain