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Irag2 inositol 1,4,5-triphosphate receptor associated 2 [ Mus musculus (house mouse) ]

Gene ID: 16970, updated on 21-Apr-2024

Summary

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Official Symbol
Irag2provided by MGI
Official Full Name
inositol 1,4,5-triphosphate receptor associated 2provided by MGI
Primary source
MGI:MGI:108424
See related
Ensembl:ENSMUSG00000030263 AllianceGenome:MGI:108424
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jaw1; Lrmp; D6Int3; D6Int4; D6Int5; D6Int7; D6Int8
Summary
Enables microtubule binding activity. Involved in nucleus organization. Located in endoplasmic reticulum membrane and nuclear envelope. Is integral component of endoplasmic reticulum membrane. Is expressed in brain; liver; and thymus primordium. Orthologous to human IRAG2 (inositol 1,4,5-triphosphate receptor associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 34.9), thymus adult (RPKM 34.3) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G3; 6 77.34 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (145061357..145120655)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (145111715..145174929)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene branched chain aminotransferase 1, cytosolic Neighboring gene predicted gene, 26666 Neighboring gene STARR-seq mESC enhancer starr_17771 Neighboring gene STARR-positive B cell enhancer ABC_E11339 Neighboring gene STARR-seq mESC enhancer starr_17772 Neighboring gene predicted gene, 38925 Neighboring gene STARR-positive B cell enhancer ABC_E8147 Neighboring gene STARR-seq mESC enhancer starr_17775 Neighboring gene STARR-seq mESC enhancer starr_17776 Neighboring gene STARR-positive B cell enhancer ABC_E2809 Neighboring gene STARR-positive B cell enhancer mm9_chr6:145072197-145072498 Neighboring gene STARR-positive B cell enhancer ABC_E4880 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene predicted gene 15543 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene Kirsten rat sarcoma viral oncogene homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Function of IRAG2 Is Modulated by NO/cGMP in Murine Platelets. Prüschenk S, et al. Int J Mol Sci, 2022 Jun 15. PMID 35743138, Free PMC Article
  2. IRAG2 Interacts with IP(3)-Receptor Types 1, 2, and 3 and Regulates Intracellular Ca(2+) in Murine Pancreatic Acinar Cells. Prüschenk S, et al. Int J Mol Sci, 2021 Dec 14. PMID 34948204, Free PMC Article
  3. Tumor suppressor p53 regulates intestinal type 2 immunity. Chang CY, et al. Nat Commun, 2021 Jun 7. PMID 34099671, Free PMC Article
  4. Lrmp and Bcat1 are candidates for the type I diabetes susceptibility locus Idd6. Grimm CH, et al. Autoimmunity, 2003 Jun. PMID 14563018
  5. Jaw1/LRMP has a role in maintaining nuclear shape via interaction with SUN proteins. Kozono T, et al. J Biochem, 2018 Oct 1. PMID 29878215

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Function of IRAG2 Is Modulated by NO/cGMP in Murine Platelets.
    Title: Function of IRAG2 Is Modulated by NO/cGMP in Murine Platelets.
  2. The Lrmp protein is associated with type III IP3 receptor (IP3R3) via its coiled-coil domain in the heterologous expression system.
    Title: Lrmp/Jaw1 is expressed in sweet, bitter, and umami receptor-expressing cells.
  3. Lrmp is a condidate for the type I diabetes susceptility locus Idd6.
    Title: Lrmp and Bcat1 are candidates for the type I diabetes susceptibility locus Idd6.
  4. We hypothesize that the observed decrease in expression of the Lrmp gene in NOD mice may constitute a T1D susceptibility factor in the Idd6 region.
    Title: The Idd6.2 diabetes susceptibility region controls defective expression of the Lrmp gene in nonobese diabetic (NOD) mice.
  5. Lrmp is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms and AA changes in lung tumor susceptibility.It may be a tumor suppressor.
    Title: Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Not Applicable (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within single fertilization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inositol 1,4,5-triphosphate receptor associated 2
Names
lymphoid-restricted membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281980.3 → NP_001268909.2  inositol 1,4,5-triphosphate receptor associated 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121950
    Consensus CDS
    CCDS39704.1

  2. NM_001281981.1 → NP_001268910.1  inositol 1,4,5-triphosphate receptor associated 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 3 and 4 both encode the same isoform (2).
    Source sequence(s)
    AC121950, AK169578
    UniProtKB/TrEMBL
    Q3TL84
    Conserved Domains (1) summary
    pfam05781
    Location:3 → 496
    MRVI1; MRVI1 protein

  3. NM_001361633.2 → NP_001348562.1  inositol 1,4,5-triphosphate receptor associated 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121950
    UniProtKB/TrEMBL
    Q3TGD7
    Related
    ENSMUSP00000120248.2, ENSMUST00000132948.2
    Conserved Domains (1) summary
    pfam05781
    Location:1 → 443
    MRVI1; MRVI1 protein

  4. NM_001368864.1 → NP_001355793.1  inositol 1,4,5-triphosphate receptor associated 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3 and 4 both encode the same isoform (2).
    Source sequence(s)
    AC121950
    UniProtKB/TrEMBL
    Q3TL84
    Conserved Domains (1) summary
    pfam05781
    Location:3 → 496
    MRVI1; MRVI1 protein

  5. NM_001428280.1 → NP_001415209.1  inositol 1,4,5-triphosphate receptor associated 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121950

  6. NM_001428281.1 → NP_001415210.1  inositol 1,4,5-triphosphate receptor associated 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC121950

  7. NM_001428282.1 → NP_001415211.1  inositol 1,4,5-triphosphate receptor associated 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC121950

  8. NM_008511.6 → NP_032537.4  inositol 1,4,5-triphosphate receptor associated 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121950
    Consensus CDS
    CCDS39704.1
    Related
    ENSMUSP00000032396.7, ENSMUST00000032396.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    145061357..145120655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241568.2 → XP_011239870.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X1

    See identical proteins and their annotated locations for XP_011239870.1

    UniProtKB/TrEMBL
    G5E880
    Conserved Domains (1) summary
    pfam05781
    Location:10 → 559
    MRVI1; MRVI1 protein

  2. XM_011241569.2 → XP_011239871.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X1

    See identical proteins and their annotated locations for XP_011239871.1

    UniProtKB/TrEMBL
    G5E880
    Conserved Domains (1) summary
    pfam05781
    Location:10 → 559
    MRVI1; MRVI1 protein

  3. XM_036165896.1 → XP_036021789.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X5

    UniProtKB/TrEMBL
    G5E880
    Conserved Domains (1) summary
    pfam05781
    Location:10 → 442
    MRVI1; MRVI1 protein

  4. XM_011241567.3 → XP_011239869.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X1

    See identical proteins and their annotated locations for XP_011239869.1

    UniProtKB/TrEMBL
    G5E880
    Conserved Domains (1) summary
    pfam05781
    Location:10 → 559
    MRVI1; MRVI1 protein

  5. XM_036165895.1 → XP_036021788.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X3

    UniProtKB/TrEMBL
    G5E880
    Conserved Domains (1) summary
    pfam05781
    Location:10 → 462
    MRVI1; MRVI1 protein

  6. XM_006506924.4 → XP_006506987.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X4

    Conserved Domains (1) summary
    pfam05781
    Location:1 → 443
    MRVI1; MRVI1 protein

  7. XM_011241571.1 → XP_011239873.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X2

    UniProtKB/TrEMBL
    Q3TL84
    Conserved Domains (1) summary
    pfam05781
    Location:30 → 516
    MRVI1; MRVI1 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60664.1 GenPept UniProtKB/Swiss-Prot:Q60664

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