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Lmo2 LIM domain only 2 [ Mus musculus (house mouse) ]

Gene ID: 16909, updated on 12-May-2024

Summary

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Official Symbol
Lmo2provided by MGI
Official Full Name
LIM domain only 2provided by MGI
Primary source
MGI:MGI:102811
See related
Ensembl:ENSMUSG00000032698 AllianceGenome:MGI:102811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ttg2; Rbtn2; Rbtn-2; Rhom-2
Summary
Enables chromatin binding activity. Contributes to DNA binding activity. Involved in negative regulation of erythrocyte differentiation. Acts upstream of or within embryonic hemopoiesis and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study acute lymphoblastic leukemia. Orthologous to human LMO2 (LIM domain only 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 70.3), liver E14.5 (RPKM 65.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E2; 2 54.46 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103788309..103812223)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (103957903..103981878)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA of erythroid differentiation 1 Neighboring gene STARR-positive B cell enhancer ABC_E9523 Neighboring gene STARR-positive B cell enhancer ABC_E638 Neighboring gene predicted gene, 39896 Neighboring gene predicted gene, 38515 Neighboring gene RIKEN cDNA 4931422A03 gene Neighboring gene STARR-seq mESC enhancer starr_05277 Neighboring gene STARR-positive B cell enhancer ABC_E5954 Neighboring gene STARR-seq mESC enhancer starr_05279 Neighboring gene F-box protein 3 Neighboring gene predicted gene, 24644

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition. Abdulla HD, et al. J Exp Med, 2023 Jun 5. PMID 36920307, Free PMC Article
  2. LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice. Hirano KI, et al. Elife, 2021 Aug 12. PMID 34382935, Free PMC Article
  3. Lmo2 expression defines tumor cell identity during T-cell leukemogenesis. García-Ramírez I, et al. EMBO J, 2018 Jul 13. PMID 29880602, Free PMC Article
  4. LMO2 induces T-cell leukemia with epigenetic deregulation of CD4. Cleveland SM, et al. Exp Hematol, 2014 Jul. PMID 24792354, Free PMC Article
  5. The molecular basis of Lmo2-induced T-cell acute lymphoblastic leukemia. Curtis DJ, et al. Clin Cancer Res, 2010 Dec 1. PMID 20861166

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition.
    Title: Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition.
  2. The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis.
    Title: The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis.
  3. LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice.
    Title: LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice.
  4. NHD13 transgenic mice lacking Lyl1 showed accelerated T-ALL and absence of transformation to AML, associated with a loss of multipotent progenitors in the bone marrow. Thus multiple T cell oncogenes induce thymocyte self-renewal via Lmo2/Lyl1.
    Title: The NUP98-HOXD13 fusion oncogene induces thymocyte self-renewal via Lmo2/Lyl1.
  5. Transient LMO2 expression is sufficient for oncogenic function and induction of T-ALL. The resulting T-ALLs lacked LMO2 and its target-gene expression, and histologically, transcriptionally, and genetically similar to human LMO2-driven T-ALL.
    Title: Lmo2 expression defines tumor cell identity during T-cell leukemogenesis.
  6. Trichostatin A (TSA, a HDAC inhibitor) addition significantly attenuates MTX unsensitivity caused by dysfunction of LMO2/ZEB1 signaling. In conclusion, these findings have identified a molecular mechanism underlying LMO2/ZEB1-mediated leukaemogenesis, paving a way for treating T-ALL with a new strategy of epigenetic inhibitors.
    Title: Epigenetic dysregulation of ZEB1 is involved in LMO2-promoted T-cell acute lymphoblastic leukaemia leukaemogenesis.
  7. Genome-wide analysis indicated that LMO2 is required at the hemangioblast stage to position the TAL1/LMO2/LDB1 complex to regulatory elements that are important for the establishment of the hematopoietic developmental program.
    Title: LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage.
  8. DNM2 mutations cooperate with Lmo2 T-cell oncogenes by enhancing IL-7 signalling.
    Title: Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.
  9. Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.
    Title: Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.
  10. HHEX is a direct transcriptional target of LMO2 consistent with its concordant gene expression.
    Title: LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within embryonic hemopoiesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rhombotin-2
Names
LIM domain only protein 2
LIM only 2
LMO-2
T-cell translocation protein 2
cysteine-rich protein TTG-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142335.2 → NP_001135807.1  rhombotin-2 isoform 2

    See identical proteins and their annotated locations for NP_001135807.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. These differences allow translation initiation from an alternate start codon and an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    BX640578
    Consensus CDS
    CCDS50651.1
    UniProtKB/TrEMBL
    A2BHP5
    Related
    ENSMUSP00000106773.2, ENSMUST00000111143.8
    Conserved Domains (2) summary
    cd09384
    Location:92 → 147
    LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
    cd09385
    Location:156 → 211
    LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)

  2. NM_001142336.1 → NP_001135808.1  rhombotin-2 isoform 3

    See identical proteins and their annotated locations for NP_001135808.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an in-frame downstream ATG and an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AK013416, AV361906, BX523983, CX226855, CX234489
    Consensus CDS
    CCDS50652.1
    UniProtKB/Swiss-Prot
    P25801
    UniProtKB/TrEMBL
    A2BHP2, Q544Z2
    Related
    ENSMUSP00000117703.2, ENSMUST00000123437.8
    Conserved Domains (2) summary
    cd09384
    Location:30 → 85
    LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
    cd09385
    Location:94 → 149
    LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)

  3. NM_001142337.2 → NP_001135809.1  rhombotin-2 isoform 3

    See identical proteins and their annotated locations for NP_001135809.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an in-frame downstream ATG and an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    BX640578
    Consensus CDS
    CCDS50652.1
    UniProtKB/Swiss-Prot
    P25801
    UniProtKB/TrEMBL
    A2BHP2, Q544Z2
    Related
    ENSMUSP00000128317.2, ENSMUST00000170926.8
    Conserved Domains (2) summary
    cd09384
    Location:30 → 85
    LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
    cd09385
    Location:94 → 149
    LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)

  4. NM_001420375.1 → NP_001407304.1  rhombotin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    BX640578

  5. NM_001420376.1 → NP_001407305.1  rhombotin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    BX640578
    UniProtKB/Swiss-Prot
    P25801
    UniProtKB/TrEMBL
    Q544Z2

  6. NM_001420377.1 → NP_001407306.1  rhombotin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    BX640578
    UniProtKB/Swiss-Prot
    P25801
    UniProtKB/TrEMBL
    Q544Z2

  7. NM_001420378.1 → NP_001407307.1  rhombotin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    BX640578
    UniProtKB/Swiss-Prot
    P25801
    UniProtKB/TrEMBL
    Q544Z2

  8. NM_001420379.1 → NP_001407308.1  rhombotin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    BX640578
    UniProtKB/Swiss-Prot
    P25801
    UniProtKB/TrEMBL
    Q544Z2

  9. NM_001420380.1 → NP_001407309.1  rhombotin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    BX640578

  10. NM_001420381.1 → NP_001407310.1  rhombotin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    BX640578

  11. NM_001420382.1 → NP_001407311.1  rhombotin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    BX640578

  12. NM_008505.5 → NP_032531.2  rhombotin-2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BX640578
    Consensus CDS
    CCDS16482.2
    UniProtKB/TrEMBL
    A2BHP3
    Related
    ENSMUSP00000106770.3, ENSMUST00000111140.3
    Conserved Domains (2) summary
    cd09384
    Location:100 → 155
    LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
    cd09385
    Location:164 → 219
    LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    103788309..103812223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498820.4 → XP_006498883.1  rhombotin-2 isoform X1

    See identical proteins and their annotated locations for XP_006498883.1

    UniProtKB/Swiss-Prot
    P25801
    UniProtKB/TrEMBL
    A2BHP2, Q544Z2
    Conserved Domains (2) summary
    cd09384
    Location:30 → 85
    LIM1_LMO2; The first LIM domain of LMO2 (LIM domain only protein 2)
    cd09385
    Location:94 → 149
    LIM2_LMO2; The second LIM domain of LMO2 (LIM domain only protein 2)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25801.1 GenPept UniProtKB/Swiss-Prot:P25801

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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