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Lmnb1 lamin B1 [ Mus musculus (house mouse) ]

Gene ID: 16906, updated on 9-Dec-2024

Summary

Official Symbol
Lmnb1provided by MGI
Official Full Name
lamin B1provided by MGI
Primary source
MGI:MGI:96795
See related
Ensembl:ENSMUSG00000024590 AllianceGenome:MGI:96795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables phospholipase binding activity and sequence-specific double-stranded DNA binding activity. A structural constituent of nuclear lamina. Predicted to be involved in several processes, including cellular response to L-glutamate; nucleus organization; and protein localization to nuclear envelope. Located in nuclear inner membrane and nuclear lumen. Is active in nuclear lamina. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and musculoskeletal system. Used to study adult-onset autosomal dominant demyelinating leukodystrophy. Human ortholog(s) of this gene implicated in adult-onset autosomal dominant demyelinating leukodystrophy and primary autosomal recessive microcephaly. Orthologous to human LMNB1 (lamin B1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in CNS E11.5 (RPKM 89.9), thymus adult (RPKM 41.9) and 17 other tissues See more
Orthologs
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Genomic context

See Lmnb1 in Genome Data Viewer
Location:
18 D3; 18 30.84 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (56840885..56886496)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (56707813..56753424)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 50288 Neighboring gene STARR-seq mESC enhancer starr_44668 Neighboring gene STARR-positive B cell enhancer ABC_E5662 Neighboring gene STARR-positive B cell enhancer ABC_E10992 Neighboring gene predicted gene, 41738 Neighboring gene STARR-seq mESC enhancer starr_44677 Neighboring gene membrane associated ring-CH-type finger 3 Neighboring gene predicted gene 15345 Neighboring gene VISTA enhancer mm109 Neighboring gene STARR-positive B cell enhancer ABC_E5663 Neighboring gene ribosomal protein S3 pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cellular response to L-glutamate  
involved_in heterochromatin formation  
involved_in nuclear envelope organization  
involved_in nuclear envelope organization  
involved_in nuclear envelope organization  
involved_in nuclear migration  
involved_in nuclear pore localization  
involved_in positive regulation of G2/M transition of mitotic cell cycle PubMed 
involved_in positive regulation of JNK cascade PubMed 
involved_in protein localization to nuclear envelope  
Component Evidence Code Pubs
located_in lamin filament PubMed 
located_in nuclear envelope PubMed 
colocalizes_with nuclear envelope  
located_in nuclear envelope  
located_in nuclear envelope  
located_in nuclear inner membrane PubMed 
is_active_in nuclear lamina  
is_active_in nuclear lamina PubMed 
located_in nuclear lamina  
located_in nuclear matrix PubMed 
located_in nuclear matrix  
located_in nuclear membrane  
located_in nuclear periphery PubMed 
located_in nucleoplasm PubMed 
located_in nucleoplasm  
located_in nucleus PubMed 
located_in nucleus  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010721.2NP_034851.2  lamin-B1

    See identical proteins and their annotated locations for NP_034851.2

    Status: VALIDATED

    Source sequence(s)
    AK132252, BC052729
    Consensus CDS
    CCDS29261.1
    UniProtKB/Swiss-Prot
    P14733, Q61791
    Related
    ENSMUSP00000025486.9, ENSMUST00000025486.9
    Conserved Domains (2) summary
    pfam00038
    Location:32388
    Filament; Intermediate filament protein
    pfam00932
    Location:440544
    LTD; Lamin Tail Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    56840885..56886496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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