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Lipe lipase, hormone sensitive [ Mus musculus (house mouse) ]

Gene ID: 16890, updated on 5-Mar-2024

Summary

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Official Symbol
Lipeprovided by MGI
Official Full Name
lipase, hormone sensitiveprovided by MGI
Primary source
MGI:MGI:96790
See related
Ensembl:ENSMUSG00000003123 AllianceGenome:MGI:96790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HSL; REH; 4933403G17Rik
Summary
Enables carboxylic ester hydrolase activity; protein kinase binding activity; and serine hydrolase activity. Involved in ether lipid metabolic process and lipid catabolic process. Acts upstream of or within cellular lipid catabolic process and cellular response to cold. Located in cytosol; lipid droplet; and membrane. Is expressed in adipose tissue; ileum; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in arteriosclerosis; familial partial lipodystrophy type 6; and hypertension. Orthologous to human LIPE (lipase E, hormone sensitive type). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 216.0), mammary gland adult (RPKM 160.3) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 13.78 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25078952..25097911, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25379527..25398486, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene multiple EGF-like-domains 8 Neighboring gene RIKEN cDNA 4732471J01 gene Neighboring gene cornifelin Neighboring gene STARR-positive B cell enhancer ABC_E2227 Neighboring gene STARR-positive B cell enhancer ABC_E11345 Neighboring gene C-X-C motif chemokine ligand 17 Neighboring gene GrpE-like 2, mitochondrial pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis. Yuksel S, et al. Commun Biol, 2023 May 17. PMID 37198396, Free PMC Article
  2. Hormone sensitive lipase ablation promotes bone regeneration. Shen WJ, et al. Biochim Biophys Acta Mol Basis Dis, 2022 Sep 1. PMID 35618183
  3. Hormone-sensitive lipase is localized at synapses and is necessary for normal memory functioning in mice. Skoug C, et al. J Lipid Res, 2022 May. PMID 35300984, Free PMC Article
  4. Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase. Pajed L, et al. Commun Biol, 2021 Mar 10. PMID 33692445, Free PMC Article
  5. The N-terminal His-tag affects the triglyceride lipase activity of hormone-sensitive lipase in testis. Wang F, et al. J Cell Biochem, 2019 Aug. PMID 30937958

See all (169) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL.
    Title: p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL.
  2. Extracellular macrophage migration inhibitory factor (MIF) downregulates adipose hormone-sensitive lipase (HSL) and contributes to obesity.
    Title: Extracellular macrophage migration inhibitory factor (MIF) downregulates adipose hormone-sensitive lipase (HSL) and contributes to obesity.
  3. SCD1-related epigenetic modifications affect hormone-sensitive lipase (Lipe) gene expression in cardiomyocytes.
    Title: SCD1-related epigenetic modifications affect hormone-sensitive lipase (Lipe) gene expression in cardiomyocytes.
  4. Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis.
    Title: Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis.
  5. Hormone sensitive lipase ablation promotes bone regeneration.
    Title: Hormone sensitive lipase ablation promotes bone regeneration.
  6. Hypothalamic hormone-sensitive lipase regulates appetite and energy homeostasis.
    Title: Hypothalamic hormone-sensitive lipase regulates appetite and energy homeostasis.
  7. Hormone-sensitive lipase deficiency affects the expression of SR-BI, LDLr, and ABCA1 receptors/transporters involved in cellular cholesterol uptake and efflux and disturbs fertility in mouse testis.
    Title: Hormone-sensitive lipase deficiency affects the expression of SR-BI, LDLr, and ABCA1 receptors/transporters involved in cellular cholesterol uptake and efflux and disturbs fertility in mouse testis.
  8. Defective Lysosomal Lipolysis Causes Prenatal Lipid Accumulation and Exacerbates Immediately after Birth.
    Title: Defective Lysosomal Lipolysis Causes Prenatal Lipid Accumulation and Exacerbates Immediately after Birth.
  9. Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase.
    Title: Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase.
  10. The N-terminal His-tag affects the triglyceride lipase activity of hormone-sensitive lipase in testis.
    Title: The N-terminal His-tag affects the triglyceride lipase activity of hormone-sensitive lipase in testis.
Submit: New GeneRIF Correction See all GeneRIFs (67)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1,2-diacylglycerol acylhydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1,3-diacylglycerol acylhydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acylglycerol lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acylglycerol lipase activity ISO
Inferred from Sequence Orthology
more info
  
enables hormone-sensitive lipase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on ester bonds ISO
Inferred from Sequence Orthology
more info
  
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA primary transcript binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables retinyl-palmitate esterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables retinyl-palmitate esterase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sterol esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sterol esterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sterol esterase activity ISO
Inferred from Sequence Orthology
more info
  
enables triglyceride lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables triglyceride lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables triglyceride lipase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables triglyceride lipase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to cold IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within diacylglycerol catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in diacylglycerol catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within diacylglycerol catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ether lipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within long-chain fatty acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in termination of RNA polymerase I transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in transcription initiation at RNA polymerase I promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within triglyceride catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within triglyceride catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in caveola ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hormone-sensitive lipase
Names
monoacylglycerol lipase LIPE
retinyl ester hydrolase
NP_001034596.1
NP_034849.2
XP_006539633.2
XP_006539635.1
XP_030098038.1
XP_030098040.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039507.2 → NP_001034596.1  hormone-sensitive lipase isoform 2

    See identical proteins and their annotated locations for NP_001034596.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC169209
    Consensus CDS
    CCDS20982.1
    UniProtKB/Swiss-Prot
    P54310, P97866, Q3TE34, Q6GU16, Q8CDI9
    Related
    ENSMUSP00000050935.8, ENSMUST00000054301.14
    Conserved Domains (2) summary
    pfam06350
    Location:6 → 314
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:345 → 493
    Abhydrolase; alpha/beta hydrolases

  2. NM_010719.5 → NP_034849.2  hormone-sensitive lipase isoform 1

    See identical proteins and their annotated locations for NP_034849.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK029984, BY513432
    Consensus CDS
    CCDS20981.1
    UniProtKB/Swiss-Prot
    P54310
    Related
    ENSMUSP00000003207.5, ENSMUST00000003207.11
    Conserved Domains (3) summary
    COG0657
    Location:378 → 535
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam06350
    Location:49 → 357
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:388 → 536
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    25078952..25097911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539570.2 → XP_006539633.2  hormone-sensitive lipase isoform X1

    UniProtKB/TrEMBL
    E9Q4M2
    Related
    ENSMUSP00000123485.2, ENSMUST00000149349.2
    Conserved Domains (2) summary
    pfam06350
    Location:304 → 612
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:643 → 791
    Abhydrolase; alpha/beta hydrolases

  2. XM_030242180.1 → XP_030098040.1  hormone-sensitive lipase isoform X2

    UniProtKB/Swiss-Prot
    P54310, P97866, Q3TE34, Q6GU16, Q8CDI9
    Conserved Domains (2) summary
    pfam06350
    Location:6 → 314
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:345 → 493
    Abhydrolase; alpha/beta hydrolases

  3. XM_030242178.1 → XP_030098038.1  hormone-sensitive lipase isoform X2

    UniProtKB/Swiss-Prot
    P54310, P97866, Q3TE34, Q6GU16, Q8CDI9
    Conserved Domains (2) summary
    pfam06350
    Location:6 → 314
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:345 → 493
    Abhydrolase; alpha/beta hydrolases

  4. XM_006539572.4 → XP_006539635.1  hormone-sensitive lipase isoform X2

    See identical proteins and their annotated locations for XP_006539635.1

    UniProtKB/Swiss-Prot
    P54310, P97866, Q3TE34, Q6GU16, Q8CDI9
    Related
    ENSMUSP00000145665.2, ENSMUST00000206861.2
    Conserved Domains (2) summary
    pfam06350
    Location:6 → 314
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:345 → 493
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54310.2 GenPept UniProtKB/Swiss-Prot:P54310

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