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Limk1 LIM domain kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 16885, updated on 5-Mar-2024

Summary

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Official Symbol
Limk1provided by MGI
Official Full Name
LIM domain kinase 1provided by MGI
Primary source
MGI:MGI:104572
See related
Ensembl:ENSMUSG00000029674 AllianceGenome:MGI:104572
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Limk; KIZ-1; LIMK-1
Summary
This gene encodes a member of the LIM kinase family of proteins. This protein is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein also stimulates axon growth and may play a role in brain development. Homozygous knockout mice for this gene exhibit reduced bone mass, abnormal neuronal morphology and altered synaptic function. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in cerebellum adult (RPKM 15.2), whole brain E14.5 (RPKM 14.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Limk1 in Genome Data Viewer
Location:
5 74.73 cM; 5 G2
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134684893..134718713, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134656039..134689859, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8085 Neighboring gene linker for activation of T cells family, member 2 Neighboring gene eukaryotic translation initiation factor 4H Neighboring gene STARR-positive B cell enhancer ABC_E1309 Neighboring gene predicted gene 10369 Neighboring gene STARR-positive B cell enhancer mm9_chr5:135180028-135180329 Neighboring gene elastin Neighboring gene predicted gene, 30003 Neighboring gene STARR-seq mESC enhancer starr_14552 Neighboring gene transmembrane protein 270

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice. Zhang H, et al. Mol Brain, 2021 Jul 27. PMID 34315506, Free PMC Article
  2. Lim Kinase1 regulates seizure activity via modulating actin dynamics. Jiang Q, et al. Neurosci Lett, 2020 Jun 11. PMID 32259557
  3. Aberrant expression of LIMK1 impairs neuronal migration during neocortex development. Xie J, et al. Histochem Cell Biol, 2017 Apr. PMID 27844143
  4. Distribution of LIM domain kinase 1 in the olfactory bulb, cerebral cortex, hippocampus, and cerebellum of the App/PS+/- mice. An L, et al. Genet Mol Res, 2015 Dec 17. PMID 26681218
  5. Roles of LIM kinases in central nervous system function and dysfunction. Cuberos H, et al. FEBS Lett, 2015 Dec 21. PMID 26545494

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RhoA-LIMK Signaling Axis Reveals Rostral-Caudal Plane and Spatial Dysregulation in the Brain of Alzheimer's Disease Mouse Models.
    Title: RhoA-LIMK Signaling Axis Reveals Rostral-Caudal Plane and Spatial Dysregulation in the Brain of Alzheimer's Disease Mouse Models.
  2. NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms.
    Title: NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms.
  3. Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice.
    Title: Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice.
  4. LncRNA Rian ameliorates sevoflurane anesthesia-induced cognitive dysfunction through regulation of miR-143-3p/LIMK1 axis.
    Title: LncRNA Rian ameliorates sevoflurane anesthesia-induced cognitive dysfunction through regulation of miR-143-3p/LIMK1 axis.
  5. Spine impairment in mice high-expressing neuregulin 1 due to LIMK1 activation.
    Title: Spine impairment in mice high-expressing neuregulin 1 due to LIMK1 activation.
  6. Lim Kinase1 regulates seizure activity via modulating actin dynamics.
    Title: Lim Kinase1 regulates seizure activity via modulating actin dynamics.
  7. Up-regulation of miR-106a targets LIMK1 and contributes to cognitive impairment induced by isoflurane anesthesia in mice.
    Title: Up-regulation of miR-106a targets LIMK1 and contributes to cognitive impairment induced by isoflurane anesthesia in mice.
  8. Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function.
    Title: Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function.
  9. Elevated cofilin activity, through the loss of Limk1, results in faster sciatic nerve growth following sciatic nerve injury.
    Title: The Cofilin/Limk1 Pathway Controls the Growth Rate of Both Developing and Regenerating Motor Axons.
  10. LIMK1 KO and LIMK2 KO mice were used to investigate the role of LIMK signaling in the cerebral cortical development.
    Title: LIMK1 and LIMK2 regulate cortical development through affecting neural progenitor cell proliferation and migration.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of axon extension IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of axon extension IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of stress fiber assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of stress fiber assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
LIM domain kinase 1
Names
LIM-domain containing, protein kinase
NP_001292804.1
NP_034847.1
XP_036020724.1
XP_036020725.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305875.1 → NP_001292804.1  LIM domain kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001292804.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons and contains an alternate 5' terminal exon, resulting in the use of an alternate translation start site, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC166938, AK141813, BQ828670, BX527775, BY230595, CV563459
    Consensus CDS
    CCDS84969.1
    UniProtKB/TrEMBL
    E9PVB6, Q3TA53
    Related
    ENSMUSP00000106864.2, ENSMUST00000111233.8
    Conserved Domains (5) summary
    cd09464
    Location:76 → 130
    LIM2_LIMK1; The second LIM domain of LIMK1 (LIM domain Kinase 1)
    smart00219
    Location:334 → 596
    TyrKc; Tyrosine kinase, catalytic domain
    cd14221
    Location:337 → 603
    STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
    pfam00595
    Location:157 → 247
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:43 → 69
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_010717.3 → NP_034847.1  LIM domain kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_034847.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK141813, BQ828670, BX527775, CJ066818, CV563459
    Consensus CDS
    CCDS19724.1
    UniProtKB/Swiss-Prot
    P53668
    UniProtKB/TrEMBL
    Q3UR47
    Related
    ENSMUSP00000015137.4, ENSMUST00000015137.10
    Conserved Domains (5) summary
    cd09462
    Location:5 → 77
    LIM1_LIMK1; The first LIM domain of LIMK1 (LIM domain Kinase 1)
    cd09464
    Location:84 → 138
    LIM2_LIMK1; The second LIM domain of LIMK1 (LIM domain Kinase 1)
    smart00219
    Location:342 → 604
    TyrKc; Tyrosine kinase, catalytic domain
    cd14221
    Location:345 → 611
    STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
    pfam00595
    Location:165 → 255
    PDZ; PDZ domain (Also known as DHR or GLGF)

RNA

  1. NR_131247.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC166938, AK141813, BQ828670, BX527775, BY230595, CV563459
    Related
    ENSMUST00000134093.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    134684893..134718713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164831.1 → XP_036020724.1  LIM domain kinase 1 isoform X1

    UniProtKB/TrEMBL
    Q3UR47
    Conserved Domains (4) summary
    cd09462
    Location:5 → 77
    LIM1_LIMK1; The first LIM domain of LIMK1 (LIM domain Kinase 1)
    cd09464
    Location:84 → 138
    LIM2_LIMK1; The second LIM domain of LIMK1 (LIM domain Kinase 1)
    cd14221
    Location:345 → 666
    STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
    pfam00595
    Location:165 → 255
    PDZ; PDZ domain (Also known as DHR or GLGF)

  2. XM_036164832.1 → XP_036020725.1  LIM domain kinase 1 isoform X2

    UniProtKB/TrEMBL
    Q3TA53
    Conserved Domains (4) summary
    cd09464
    Location:76 → 130
    LIM2_LIMK1; The second LIM domain of LIMK1 (LIM domain Kinase 1)
    cd14221
    Location:337 → 658
    STKc_LIMK1; Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1
    pfam00595
    Location:157 → 247
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl02475
    Location:43 → 69
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53668.1 GenPept UniProtKB/Swiss-Prot:P53668

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