Lhcgr luteinizing hormone/choriogonadotropin receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lhcgrprovided by MGI
Official Full Name: luteinizing hormone/choriogonadotropin receptorprovided by MGI
Primary source: MGI:MGI:96783
See related: Ensembl:ENSMUSG00000024107 AllianceGenome:MGI:96783
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lhr; LH-R; LSH-R; LH/CG-R; Gpcr19-rs1
Summary: Enables choriogonadotropin hormone binding activity and choriogonadotropin hormone receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; activation of adenylate cyclase activity; and positive regulation of inositol trisphosphate biosynthetic process. Acts upstream of or within several processes, including development of secondary male sexual characteristics; regulation of steroid hormone biosynthetic process; and reproductive structure development. Is integral component of plasma membrane. Is expressed in early conceptus; medulla oblongata; medulla oblongata basal plate ventricular layer; oocyte; and testis. Human ortholog(s) of this gene implicated in Leydig cell hypoplasia; Leydig cell tumor; breast cancer; familial male-limited precocious puberty; and gonadal disease. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward ovary adult (RPKM 46.2) See more
Orthologs: human all
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Genomic context

Location:: 17 E4; 17 58.35 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (89023812..89099487, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (88716384..88792059, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Precise Correction of Lhcgr Mutation in Stem Leydig Cells by Prime Editing Rescues Hereditary Primary Hypogonadism in Mice.
Title: Precise Correction of Lhcgr Mutation in Stem Leydig Cells by Prime Editing Rescues Hereditary Primary Hypogonadism in Mice.
The Corticosterone-Glucocorticoid Receptor-AP1/CREB Axis Inhibits the Luteinizing Hormone Receptor Expression in Mouse Granulosa Cells.
Title: The Corticosterone-Glucocorticoid Receptor-AP1/CREB Axis Inhibits the Luteinizing Hormone Receptor Expression in Mouse Granulosa Cells.
Downregulation of LHCGR Attenuates COX-2 Expression and Induces Luteinized Unruptured Follicle Syndrome in Endometriosis.
Title: Downregulation of LHCGR Attenuates COX-2 Expression and Induces Luteinized Unruptured Follicle Syndrome in Endometriosis.
LHCGR and ALMS1 defects likely cooperate in the development of polycystic ovary syndrome indicated by double-mutant mice.
Title: LHCGR and ALMS1 defects likely cooperate in the development of polycystic ovary syndrome indicated by double-mutant mice.
Constitutive LH receptor activity impairs NO-mediated penile smooth muscle relaxation.
Title: Constitutive LH receptor activity impairs NO-mediated penile smooth muscle relaxation.
The Luteinizing Hormone Receptor Knockout Mouse as a Tool to Probe the In Vivo Actions of Gonadotropic Hormones/Receptors in Females.
Title: The Luteinizing Hormone Receptor Knockout Mouse as a Tool to Probe the In Vivo Actions of Gonadotropic Hormones/Receptors in Females.
Impact of lipopolysaccharide administration on luteinizing hormone/choriogonadotropin receptor (Lhcgr) expression in mouse ovaries.
Title: Impact of lipopolysaccharide administration on luteinizing hormone/choriogonadotropin receptor (Lhcgr) expression in mouse ovaries.
Cellular Heterogeneity of the Luteinizing Hormone Receptor and Its Significance for Cyclic GMP Signaling in Mouse Preovulatory Follicles.
Title: Cellular Heterogeneity of the Luteinizing Hormone Receptor and Its Significance for Cyclic GMP Signaling in Mouse Preovulatory Follicles.
Type 1 Diabetes Mellitus Impairs LH-LHCGR Signaling in the Ovaries and Decreases Female Fertility in Mice
Title: Poorly-Controlled Type 1 Diabetes Mellitus Impairs LH-LHCGR Signaling in the Ovaries and Decreases Female Fertility in Mice.
Activating mutations in LHCGR cause familial male-limited precocious puberty
Title: Constitutive luteinizing hormone receptor signaling causes sexual dysfunction and Leydig cell adenomas in male mice.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M81310 (e-PCR)
- UniSTS:186118

Lhcgr (e-PCR), detects polymorphism
- UniSTS:257100

Lhcgr (e-PCR), detects polymorphism
- UniSTS:257101

PMC85975P2 (e-PCR)
- UniSTS:273500

Lhcgr (e-PCR), detects polymorphism
- UniSTS:526973

Fshr (e-PCR), detects polymorphism
- UniSTS:305549

Fshr (e-PCR), detects polymorphism
- UniSTS:305550

Lhcgr (e-PCR), detects polymorphism
- UniSTS:305551

Lhcgr (e-PCR), detects polymorphism
- UniSTS:305552

LHCGR (e-PCR)
- UniSTS:507368

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables choriogonadotropin hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables choriogonadotropin hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables choriogonadotropin hormone receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables luteinizing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables luteinizing hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables luteinizing hormone receptor activity	TAS Traceable Author Statement more info	PubMed
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables protein-hormone receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activation of adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in arachidonic acid secretion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gonadotropin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to luteinizing hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within development of secondary male sexual characteristics	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in luteinizing hormone signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in luteinizing hormone signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian follicle development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovulation cycle process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ovulation cycle process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hormone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inositol trisphosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to lysosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of steroid hormone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to luteinizing hormone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within seminiferous tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within uterus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lutropin-choriogonadotropic hormone receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364898.1 → NP_001351827.1 lutropin-choriogonadotropic hormone receptor isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC154459, AK030325, AK054331, AK054542

Conserved Domains (2) summary

sd00033
Location:55 → 78

LRR_RI; leucine-rich repeat [structural motif]

cl26222
Location:66 → 204

LRR_5; Leucine rich repeats (6 copies)
NM_013582.3 → NP_038610.1 lutropin-choriogonadotropic hormone receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_038610.1

Status: VALIDATED

Source sequence(s)

AC154459

Consensus CDS

CCDS29025.1

UniProtKB/Swiss-Prot

P30730

Related

ENSMUSP00000024916.6, ENSMUST00000024916.7

Conserved Domains (3) summary

sd00033
Location:55 → 78

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:380 → 627

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13306
Location:66 → 204

LRR_5; Leucine rich repeats (6 copies)

RNA

NR_157357.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC154459, AK030325, AK054542

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

89023812..89099487 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011246310.3 → XP_011244612.1 lutropin-choriogonadotropic hormone receptor isoform X9

Conserved Domains (2) summary

sd00033
Location:55 → 78

LRR_RI; leucine-rich repeat [structural motif]

pfam13306
Location:66 → 204

LRR_5; Leucine rich repeats (6 copies)
XM_036160343.1 → XP_036016236.1 lutropin-choriogonadotropic hormone receptor isoform X11

Conserved Domains (2) summary

sd00033
Location:55 → 78

LRR_RI; leucine-rich repeat [structural motif]

pfam13306
Location:66 → 204

LRR_5; Leucine rich repeats (6 copies)
XM_006523723.2 → XP_006523786.1 lutropin-choriogonadotropic hormone receptor isoform X6

Conserved Domains (2) summary

sd00031
Location:55 → 77

LRR_1; leucine-rich repeat [structural motif]

cd15359
Location:240 → 513

7tmA_LHCGR; luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006523722.2 → XP_006523785.1 lutropin-choriogonadotropic hormone receptor isoform X5

Conserved Domains (2) summary

sd00031
Location:108 → 128

LRR_1; leucine-rich repeat [structural motif]

cd15359
Location:291 → 564

7tmA_LHCGR; luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006523720.2 → XP_006523783.1 lutropin-choriogonadotropic hormone receptor isoform X3

Conserved Domains (3) summary

sd00033
Location:80 → 101

LRR_RI; leucine-rich repeat [structural motif]

cd15359
Location:316 → 589

7tmA_LHCGR; luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

pfam13306
Location:64 → 164

LRR_5; Leucine rich repeats (6 copies)
XM_006523719.2 → XP_006523782.1 lutropin-choriogonadotropic hormone receptor isoform X1

Conserved Domains (3) summary

sd00033
Location:80 → 104

LRR_RI; leucine-rich repeat [structural motif]

cd15359
Location:341 → 614

7tmA_LHCGR; luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

pfam13306
Location:59 → 180

LRR_5; Leucine rich repeats (6 copies)
XM_006523721.2 → XP_006523784.1 lutropin-choriogonadotropic hormone receptor isoform X4

Conserved Domains (3) summary

sd00033
Location:55 → 78

LRR_RI; leucine-rich repeat [structural motif]

cd15359
Location:315 → 588

7tmA_LHCGR; luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

pfam13306
Location:65 → 163

LRR_5; Leucine rich repeats (6 copies)
XM_036160339.1 → XP_036016232.1 lutropin-choriogonadotropic hormone receptor isoform X2

Conserved Domains (3) summary

sd00033
Location:79 → 103

LRR_RI; leucine-rich repeat [structural motif]

cd15359
Location:340 → 613

7tmA_LHCGR; luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

pfam13306
Location:66 → 188

LRR_5; Leucine rich repeats (6 copies)
XM_036160340.1 → XP_036016233.1 lutropin-choriogonadotropic hormone receptor isoform X7

Conserved Domains (4) summary

sd00033
Location:55 → 78

LRR_RI; leucine-rich repeat [structural motif]

pfam13306
Location:66 → 204

LRR_5; Leucine rich repeats (6 copies)

cd14964
Location:341 → 363

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:316 → 494

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_036160341.1 → XP_036016234.1 lutropin-choriogonadotropic hormone receptor isoform X8

Conserved Domains (2) summary

sd00033
Location:55 → 78

LRR_RI; leucine-rich repeat [structural motif]

pfam13306
Location:66 → 204

LRR_5; Leucine rich repeats (6 copies)
XM_036160342.1 → XP_036016235.1 lutropin-choriogonadotropic hormone receptor isoform X10

Conserved Domains (2) summary

sd00033
Location:55 → 78

LRR_RI; leucine-rich repeat [structural motif]

pfam13306
Location:66 → 204

LRR_5; Leucine rich repeats (6 copies)
XM_036160344.1 → XP_036016237.1 lutropin-choriogonadotropic hormone receptor isoform X12

Conserved Domains (2) summary

sd00033
Location:55 → 78

LRR_RI; leucine-rich repeat [structural motif]

pfam13306
Location:66 → 204

LRR_5; Leucine rich repeats (6 copies)