Lhb luteinizing hormone beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lhbprovided by MGI
Official Full Name: luteinizing hormone betaprovided by MGI
Primary source: MGI:MGI:96782
See related: Ensembl:ENSMUSG00000100916 AllianceGenome:MGI:96782
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LH; LH-B; LSH-B; Gm29035; LSH-beta
Summary: Predicted to enable hormone activity. Acts upstream of or within luteinizing hormone signaling pathway involved in ovarian follicle development. Located in cytoplasm. Is expressed in alimentary system; brain; genitourinary system; and heart. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 23 with or without anosmia. Orthologous to several human genes including LHB (luteinizing hormone subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 15.7), lung adult (RPKM 7.4) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.3 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (45070370..45071278)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45417608..45421855)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells.
Title: Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells.
Biphasic Roles of Clock Genes and Bone Morphogenetic Proteins in Gonadotropin Expression by Mouse Gonadotrope Cells.
Title: Biphasic Roles of Clock Genes and Bone Morphogenetic Proteins in Gonadotropin Expression by Mouse Gonadotrope Cells.
Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on the LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line.
Title: Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on the LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line.
The male neuroendocrine reproductive axis is quite sensitive to short-term stress exposure, with significantly decreased pulsatile LH secretion and increased hypothalamic Rfrp neuronal activation occurring rapidly, within minutes, and decreased Kiss1 neuronal activation also occurring after longer stress durations.
Title: Stress rapidly suppresses in vivo LH pulses and increases activation of RFRP-3 neurons in male mice.
Physiologically, steroid sex hormones stimulate follicle growth by activating YAP1; however, the preovulatory inhibition of YAP1 activity in granulosa cells is a prerequisite of LH actions.
Title: The polycystic ovary syndrome-associated gene Yap1 is regulated by gonadotropins and sex steroid hormones in hyperandrogenism-induced oligo-ovulation in mouse.
Data show that estradiol or bisphenol A decreased expression of luteinizing hormone beta (Lhb), follicle stimulating hormone beta (Fshb), and intracellular adhesion molecule-5 (Icam5) in females but only decreased expression of Icam5 in males.
Title: Icam5 Expression Exhibits Sex Differences in the Neonatal Pituitary and Is Regulated by Estradiol and Bisphenol A.
WT1 can modulate LHbeta transcription with differential roles for the two WT1 variants
Title: A new role for wilms tumor protein 1: differential activities of + KTS and -KTS variants to regulate LHβ transcription.
progesterone signaling specifically in kisspeptin cells essential for the positive feedback induction of normal LH surges, ovulation, and normal fertility in females
Title: Absent Progesterone Signaling in Kisspeptin Neurons Disrupts the LH Surge and Impairs Fertility in Female Mice.
SCGB3A2 regulates FSH/LH production in the anterior pituitary lobe.
Title: Regulation of LH/FSH expression by secretoglobin 3A2 in the mouse pituitary gland.
This is the first conclusive evidence for the physiological importance of the activation of Gq/11 by the LH receptor and for the involvement of Galphaq/11 in ovulation.
Title: Ovulation involves the luteinizing hormone-dependent activation of G(q/11) in granulosa cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484917

Lhb (e-PCR), detects polymorphism
- UniSTS:143777

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within luteinizing hormone signaling pathway involved in ovarian follicle development	IDA Inferred from Direct Assay more info	PubMed
involved_in organic cyclic compound metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of pituitary gonadotropin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lutropin subunit beta

Names: leutropin; luteinizing hormone subunit beta; lutropin beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.