Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lfngprovided by MGI
Official Full Name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseprovided by MGI
Primary source: MGI:MGI:1095413
See related: Ensembl:ENSMUSG00000029570 AllianceGenome:MGI:1095413
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Involved in lymphocyte differentiation; negative regulation of Notch signaling pathway involved in somitogenesis; and somitogenesis. Acts upstream of or within several processes, including compartment pattern specification; positive regulation of Notch signaling pathway; and regulation of somitogenesis. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; inner ear; and paraxial mesenchyme. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 77.7), mammary gland adult (RPKM 72.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 79.15 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (140593096..140601300)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (140607341..140615545)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lunatic Fringe-GFP Marks Lamina-Specific Astrocytes That Regulate Sensory Processing.
Title: Lunatic Fringe-GFP Marks Lamina-Specific Astrocytes That Regulate Sensory Processing.
LFNG expression plays a functional role in regulating melanoma metastasis.
Title: Comparative genomics reveals that loss of lunatic fringe (LFNG) promotes melanoma metastasis.
results suggest that mir-125a sites in the Lfng 3' untranslated region influence transcript turnover in both mouse and chicken embryos, and support the existence of position-dependent regulatory mechanisms in the presomitic mesoderm.
Title: Putative binding sites for mir-125 family miRNAs in the mouse Lfng 3'UTR affect transcript expression in the segmentation clock, but mir-125a-5p is dispensable for normal somitogenesis.
Lfng-mediated Notch signaling appears to be a key factor governing NSC quiescence, division, and fate.
Title: Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance.
These results show that Notch signaling is finely calibrated in the cochlea via Lfng and Mfng to produce precisely tuned levels of signaling that first set the boundary of the organ of Corti and later regulate hair cell development.
Title: Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates.
a potent tumor-suppressive function for Lfng
Title: Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer.
Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.
Title: Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands.
LFNG protein may have context-dependent effects on Notch activity; somitogenesis is disrupted by a novel dominant allele of Lfng
Title: Disruption of somitogenesis by a novel dominant allele of Lfng suggests important roles for protein processing and secretion.
each Fringe contributes to T and B cell development, and Fringe is required for optimal in vitro stimulation of T and B cells.
Title: Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.
Lfng expression and activity is normal in mice whose Lfng is lengthened by 10 kb, and no effects on segmentation are evident.
Title: Modifying transcript lengths of cycling mouse segmentation genes.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	ISO Inferred from Sequence Orthology more info
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	TAS Traceable Author Statement more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within compartment pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in marginal zone B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Notch signaling pathway involved in somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pattern specification process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of somitogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

Names: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; lunatic fringe

NP_032520.1

EC 2.4.1.222

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.