Lepr leptin receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Leprprovided by MGI
Official Full Name: leptin receptorprovided by MGI
Primary source: MGI:MGI:104993
See related: Ensembl:ENSMUSG00000057722 AllianceGenome:MGI:104993
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: db; Obr; obl; Leprb; Modb1; LEPROT; OB-RGRP; diabetes; obese-like
Summary: Enables leptin receptor activity. Involved in several processes, including energy homeostasis; leptin-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including glial cell proliferation; glycogen metabolic process; and negative regulation of gluconeogenesis. Predicted to be located in extracellular space and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb segment; and skeleton. Used to study non-alcoholic fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 5.0), placenta adult (RPKM 3.3) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C6; 4 46.96 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (101574393..101676375)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (101717137..101815352)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leptin Receptor Deficiency Impairs Lymph Node Development and Adaptive Immune Response.
Title: Leptin Receptor Deficiency Impairs Lymph Node Development and Adaptive Immune Response.
Influence of leptin and its receptors on individuals under chronic social stress behavior.
Title: Influence of leptin and its receptors on individuals under chronic social stress behavior.
Immunomodulatory leptin receptor[+] sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis.
Title: Immunomodulatory leptin receptor(+) sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis.
ANGPTL4 binds to the leptin receptor to regulate ectopic bone formation.
Title: ANGPTL4 binds to the leptin receptor to regulate ectopic bone formation.
The leptin receptor has no role in delta-cell control of beta-cell function in the mouse.
Title: The leptin receptor has no role in delta-cell control of beta-cell function in the mouse.
Altered function of arcuate leptin receptor expressing neuropeptide Y neurons depending on energy balance.
Title: Altered function of arcuate leptin receptor expressing neuropeptide Y neurons depending on energy balance.
Leptin/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages.
Title: Leptin/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages.
Metabolic rewiring and epigenetic reprogramming in leptin receptor-deficient db/db diabetic nephropathy mice.
Title: Metabolic rewiring and epigenetic reprogramming in leptin receptor-deficient db/db diabetic nephropathy mice.
Deletion of endothelial leptin receptors in mice promotes diet-induced obesity.
Title: Deletion of endothelial leptin receptors in mice promotes diet-induced obesity.
Endothelial and Leptin Receptor[+] cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow.
Title: Endothelial and Leptin Receptor(+) cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow.

Submit: New GeneRIF Correction See all GeneRIFs (259)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (16) 1 citation
Transgenic (1) 1 citation
Targeted (22) 1 citation
Chemically induced (ENU) (13) 1 citation
Endonuclease-mediated (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lepr (e-PCR), detects polymorphism
- UniSTS:265232

Lepr (e-PCR), detects polymorphism
- UniSTS:265233

PMC104257P1 (e-PCR)
- UniSTS:270105

PMC104257P2 (e-PCR)
- UniSTS:270106

BE687169 (e-PCR)
- UniSTS:207647

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

U52915 (e-PCR)
- UniSTS:125770

LEPR-2 (e-PCR)
- UniSTS:254061

Lepr (e-PCR), detects polymorphism
- UniSTS:143773

PMC21274P1 (e-PCR)
- UniSTS:272030

Lepr (e-PCR), detects polymorphism
- UniSTS:143774

PMC21274P2 (e-PCR)
- UniSTS:272031

PMC21274P3 (e-PCR)
- UniSTS:272032

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables leptin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables leptin receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in bone growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cholesterol metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glycogen metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in leptin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leptin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of eating behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of hydrolase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of locomotor rhythm	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transport	ISO Inferred from Sequence Orthology more info
involved_in response to leptin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sexual reproduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: leptin receptor

Names: B219; LEP-R; OB receptor; leptin receptor gene-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122899.2 → NP_001116371.1 leptin receptor isoform 3 precursor

See identical proteins and their annotated locations for NP_001116371.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate 3' exon, as compared to variant 1. The resultign isoform (3) has a different and shorter C-terminus, as compared to isoform 1.

Source sequence(s)

AL929373

Consensus CDS

CCDS51239.1

UniProtKB/TrEMBL

Q3US58, Q640Q2

Related

ENSMUSP00000102534.3, ENSMUST00000106921.9

Conserved Domains (3) summary

smart00060
Location:737 → 818

FN3; Fibronectin type 3 domain

cd00063
Location:236 → 328

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:331 → 418

Lep_receptor_Ig; Ig-like C2-type domain
NM_010704.2 → NP_034834.1 leptin receptor isoform 2 precursor

See identical proteins and their annotated locations for NP_034834.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks the 3' exon but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) has a different and shorter C-terminus, as compared to isoform 1.

Source sequence(s)

AK143989, CN692760

Consensus CDS

CCDS18397.1

UniProtKB/TrEMBL

Q3UNU8, Q640Q2

Related

ENSMUSP00000099838.4, ENSMUST00000102777.10

Conserved Domains (3) summary

smart00060
Location:737 → 818

FN3; Fibronectin type 3 domain

cd00063
Location:236 → 328

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:331 → 418

Lep_receptor_Ig; Ig-like C2-type domain
NM_146146.3 → NP_666258.2 leptin receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_666258.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL929373

Consensus CDS

CCDS51240.1

UniProtKB/Swiss-Prot

O35686, O54986, P48356, Q61215, Q64309, Q9QWG3, Q9QWV5

Related

ENSMUSP00000037385.4, ENSMUST00000037552.10

Conserved Domains (3) summary

smart00060
Location:737 → 818

FN3; Fibronectin type 3 domain

cd00063
Location:236 → 328

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:331 → 418

Lep_receptor_Ig; Ig-like C2-type domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

101574393..101676375

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163750.1 → XP_036019643.1 leptin receptor isoform X1

Conserved Domains (4) summary

smart00060
Location:738 → 819

FN3; Fibronectin type 3 domain

cd00063
Location:237 → 329

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:328 → 419

Lep_receptor_Ig; Ig-like C2-type domain

pfam18589
Location:430 → 532

ObR_Ig; Obesity receptor immunoglobulin like domain
XM_036163752.1 → XP_036019645.1 leptin receptor isoform X3

UniProtKB/TrEMBL

Q640Q2

Conserved Domains (4) summary

smart00060
Location:738 → 819

FN3; Fibronectin type 3 domain

cd00063
Location:237 → 329

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:328 → 419

Lep_receptor_Ig; Ig-like C2-type domain

pfam18589
Location:430 → 532

ObR_Ig; Obesity receptor immunoglobulin like domain
XM_036163751.1 → XP_036019644.1 leptin receptor isoform X2

UniProtKB/TrEMBL

Q640Q2

Conserved Domains (4) summary

smart00060
Location:738 → 819

FN3; Fibronectin type 3 domain

cd00063
Location:237 → 329

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:328 → 419

Lep_receptor_Ig; Ig-like C2-type domain

pfam18589
Location:430 → 532

ObR_Ig; Obesity receptor immunoglobulin like domain