Cnmd chondromodulin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnmdprovided by MGI
Official Full Name: chondromodulinprovided by MGI
Primary source: MGI:MGI:1341171
See related: Ensembl:ENSMUSG00000022025 AllianceGenome:MGI:1341171
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Chmd; ChM-I; Lect1; Bricd3
Summary: Acts upstream of or within several processes, including endothelial cell morphogenesis; negative regulation of endothelial cell proliferation; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in extracellular region. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart valve; musculoskeletal system; and sensory organ. Orthologous to human CNMD (chondromodulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in limb E14.5 (RPKM 98.5), ovary adult (RPKM 23.0) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 42.74 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (79875126..79899596, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (79637682..79662194, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chondromodulin is necessary for cartilage callus distraction in mice.
Title: Chondromodulin is necessary for cartilage callus distraction in mice.
These findings indicated that Chm-I was an indispensable factor for ectopic cartilage regeneration and the maintenance of cartilage homeostasis.
Title: The influence of Chm-I knockout on ectopic cartilage regeneration and homeostasis maintenance.
intact 20-25 kDa ChM-I is stored as a component of extracellular matrix in the avascular cartilage zones, but it is inactivated by a single N-terminal proteolytic cleavage in the hypertrophic zone of growth-plate cartilage
Title: The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development.
the inhibitory action of ChM-I on trophoblast migration and invasion, implying the potential role of the ChM-I expression in decidual cells for the regulated tissue remodeling and angiogenesis at feto-maternal interface.
Title: Localization of chondromodulin-I at the feto-maternal interface and its inhibitory actions on trophoblast invasion in vitro.
chondromodulin 1 stabilizes the chondrocyte phenotype by supporting chondrogenesis but inhibiting chondrocyte hypertrophy and endochondral ossification.
Title: Chondromodulin 1 stabilizes the chondrocyte phenotype and inhibits endochondral ossification of porcine cartilage repair tissue.
results suggest that Chm-I is involved in hypertrophic maturation of periosteal chondrocytes. Although a direct effect of Chm-I on bones is still unclear, bony callus formation was increased while external cartilaginous callus decreased in Chm1(-/-) mice
Title: Altered fracture callus formation in chondromodulin-I deficient mice.
The expression domains of ChM-I and TeM during vertebrate development incorporate the typical avascular regions of the mesenchymal tissues.
Title: Chondromodulin-I and tenomodulin are differentially expressed in the avascular mesenchyme during mouse and chick development.
Chondromodulin I suppresses T cell responses and synovial cell proliferation, implying that this cartilage matrix protein has a therapeutic potential in rheumatoid arthritis.
Title: Suppression of T cell responses by chondromodulin I, a cartilage-derived angiogenesis inhibitory factor: therapeutic potential in rheumatoid arthritis.
chondromodulin-I has a pivotal role in maintaining valvular normal function by preventing angiogenesis that may lead to valvular heart diseases
Title: Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis.
Role of ChM-I in cartilage and eye development
Title: Chondromodulin I is dispensable during enchondral ossification and eye development.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelial cell morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of ossification	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leukocyte cell-derived chemotaxin 1

Names: Chondromodulin 1; chondromodulin-1; chondromodulin-I; leukocyte cell derived chemotaxin 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310655.2 → NP_001297584.1 leukocyte cell-derived chemotaxin 1 isoform 1

See identical proteins and their annotated locations for NP_001297584.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC122356, AC129216

Consensus CDS

CCDS79348.1

UniProtKB/TrEMBL

G5E8Z6

Related

ENSMUSP00000126958.2, ENSMUST00000165835.8

Conserved Domains (1) summary

smart01039
Location:105 → 201

BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer
NM_001424483.1 → NP_001411412.1 leukocyte cell-derived chemotaxin 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC122356, AC129216
NM_001424484.1 → NP_001411413.1 leukocyte cell-derived chemotaxin 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC122356, AC129216
NM_001424485.1 → NP_001411414.1 leukocyte cell-derived chemotaxin 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC122356, AC129216
NM_001424486.1 → NP_001411415.1 leukocyte cell-derived chemotaxin 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC122356, AC129216
NM_001424487.1 → NP_001411416.1 leukocyte cell-derived chemotaxin 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC122356, AC129216
NM_010701.4 → NP_034831.2 leukocyte cell-derived chemotaxin 1 isoform 2

See identical proteins and their annotated locations for NP_034831.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) has the same N- and C- termini, but is four amino acids shorter than isoform 1.

Source sequence(s)

AC122356, AC129216

Consensus CDS

CCDS27302.1

UniProtKB/Swiss-Prot

Q80UX1, Q9CXU5, Q9Z1F6

Related

ENSMUSP00000022603.8, ENSMUST00000022603.8

Conserved Domains (1) summary

smart01039
Location:105 → 201

BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer