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Ldhc lactate dehydrogenase C [ Mus musculus (house mouse) ]

Gene ID: 16833, updated on 5-Mar-2024

Summary

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Official Symbol
Ldhcprovided by MGI
Official Full Name
lactate dehydrogenase Cprovided by MGI
Primary source
MGI:MGI:96764
See related
Ensembl:ENSMUSG00000030851 AllianceGenome:MGI:96764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ldh3; Ldh-3; Ldh-x; Ldhc4; LDH-C4
Summary
Enables L-lactate dehydrogenase activity. Acts upstream of or within ATP biosynthetic process; flagellated sperm motility; and lactate metabolic process. Located in cytoplasm and motile cilium. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human LDHC (lactate dehydrogenase C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 1111.1) See more
Orthologs
human all
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Genomic context

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See Ldhc in Genome Data Viewer
Location:
7 B3; 7 30.6 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46510687..46527571)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46861263..46878147)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18874 Neighboring gene predicted gene 5331 Neighboring gene lactate dehydrogenase A Neighboring gene predicted gene, 39011 Neighboring gene tumor susceptibility gene 101 Neighboring gene STARR-seq mESC enhancer starr_18876 Neighboring gene UEV and lactate/malate dehyrogenase domains Neighboring gene predicted gene, 39012

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance. Tung KS, et al. J Clin Invest, 2017 Mar 1. PMID 28218625, Free PMC Article
  2. Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis. Teng X, et al. ACS Chem Biol, 2016 Sep 16. PMID 27333189, Free PMC Article
  3. Glycolysis and mitochondrial respiration in mouse LDHC-null sperm. Odet F, et al. Biol Reprod, 2013 Apr. PMID 23486916, Free PMC Article
  4. Lactate dehydrogenase C and energy metabolism in mouse sperm. Odet F, et al. Biol Reprod, 2011 Sep. PMID 21565994, Free PMC Article
  5. LDHC: the ultimate testis-specific gene. Goldberg E, et al. J Androl, 2010 Jan-Feb. PMID 19875487, Free PMC Article

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the LDHA protein level was remarkably decreased in Ldhc-deficient sperm, indicating that LDHC is required for LDHA expression in the sperm.
    Title: Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A.
  2. polymorphisms in the Ldhc gene control testis levels of S-2HG, and thereby epigenetics, across mammals
    Title: Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis.
  3. Human LDHA was introduced as a transgene to Ldhc-null mice and rescued sperm function.
    Title: Human lactate dehydrogenase A (LDHA) rescues mouse Ldhc-null sperm function.
  4. C57BL/6 and 129S6 Ldhc KO mice were subfertile and infertile respectively.
    Title: Glycolysis and mitochondrial respiration in mouse LDHC-null sperm.
  5. part of a complex involved in ATP homeostasis in sperm
    Title: Lactate dehydrogenase C and energy metabolism in mouse sperm.
  6. required for sperm to accomplish fertilization
    Title: LDHC: the ultimate testis-specific gene.
  7. LDHC plays an essential role in maintenance of the processes of glycolysis and ATP production in the flagellum that are required for male fertility and sperm function.
    Title: Expression of the gene for mouse lactate dehydrogenase C (Ldhc) is required for male fertility.
  8. Simultaneous occupancy of the GC box and CRE sites in the core promoter is necessary for full expression of Ldhc in the testis.
    Title: Regulation of murine lactate dehydrogenase C (Ldhc) gene expression.
  9. beta-agonists increased serum LDH levels, but it was not due to release from the heart.
    Title: Beta-agonists enhance the lactic dehydrogenase (LDH) expression in serum and ventricular myocytes of mice.
  10. The high level of LDH-C(4) in postmeiotic cells results from mRNA and protein stability.
    Title: A transgenic analysis of mouse lactate dehydrogenase C promoter activity in the testis.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-lactate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-lactate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within ATP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lactate biosynthetic process from pyruvate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lactate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lactate oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyruvate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pyruvate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
L-lactate dehydrogenase C chain
Names
LDH testis subunit
LDH-C
lactate dehydrogenase 3, C chain, sperm specific
lactate dehydrogenase-X
NP_001355290.1
NP_001355291.1
NP_038608.1
XP_006540742.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368361.1 → NP_001355290.1  L-lactate dehydrogenase C chain

    Status: VALIDATED

    Source sequence(s)
    AC090123
    Consensus CDS
    CCDS21290.1
    UniProtKB/Swiss-Prot
    P00342
    UniProtKB/TrEMBL
    Q548Z6, Q64483
    Conserved Domains (1) summary
    cd05293
    Location:19 → 329
    LDH_1; A subgroup of L-lactate dehydrogenases

  2. NM_001368362.1 → NP_001355291.1  L-lactate dehydrogenase C chain

    Status: VALIDATED

    Source sequence(s)
    AC090123
    Consensus CDS
    CCDS21290.1
    UniProtKB/Swiss-Prot
    P00342
    UniProtKB/TrEMBL
    Q548Z6, Q64483
    Conserved Domains (1) summary
    cd05293
    Location:19 → 329
    LDH_1; A subgroup of L-lactate dehydrogenases

  3. NM_013580.4 → NP_038608.1  L-lactate dehydrogenase C chain

    See identical proteins and their annotated locations for NP_038608.1

    Status: VALIDATED

    Source sequence(s)
    AC090123
    Consensus CDS
    CCDS21290.1
    UniProtKB/Swiss-Prot
    P00342
    UniProtKB/TrEMBL
    Q548Z6, Q64483
    Related
    ENSMUSP00000014545.5, ENSMUST00000014545.11
    Conserved Domains (1) summary
    cd05293
    Location:19 → 329
    LDH_1; A subgroup of L-lactate dehydrogenases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    46510687..46527571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540679.1 → XP_006540742.1  L-lactate dehydrogenase C chain isoform X1

    See identical proteins and their annotated locations for XP_006540742.1

    UniProtKB/Swiss-Prot
    P00342
    UniProtKB/TrEMBL
    Q548Z6, Q64483
    Conserved Domains (1) summary
    cd05293
    Location:19 → 329
    LDH_1; A subgroup of L-lactate dehydrogenases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00342.2 GenPept UniProtKB/Swiss-Prot:P00342

Gene LinkOut

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