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Ldha lactate dehydrogenase A [ Mus musculus (house mouse) ]

Gene ID: 16828, updated on 11-Apr-2024

Summary

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Official Symbol
Ldhaprovided by MGI
Official Full Name
lactate dehydrogenase Aprovided by MGI
Primary source
MGI:MGI:96759
See related
Ensembl:ENSMUSG00000063229 AllianceGenome:MGI:96759
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ldh1; Ldhm; l7R2
Summary
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to hemolytic anemia and early postimplantation death in mice. Multiple transcript variants encoding different isoforms have been found for this gene. The mouse genome contains multiple pseudogenes of this gene. [provided by RefSeq, May 2013]
Expression
Ubiquitous expression in liver E18 (RPKM 539.4), mammary gland adult (RPKM 508.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ldha in Genome Data Viewer
Location:
7 B3; 7 30.6 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46491698..46505051)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46842274..46855627)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene general transcription factor II H, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_18872 Neighboring gene Rap1A-retro1 Neighboring gene STARR-seq mESC enhancer starr_18874 Neighboring gene predicted gene 5331 Neighboring gene predicted gene, 39011 Neighboring gene lactate dehydrogenase C Neighboring gene tumor susceptibility gene 101 Neighboring gene STARR-seq mESC enhancer starr_18876

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer. Liu J, et al. Nat Metab, 2022 Dec. PMID 36536137, Free PMC Article
  2. LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization. Chen Y, et al. Redox Biol, 2022 Oct. PMID 36057161, Free PMC Article
  3. Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development. Serra M, et al. Cell Mol Gastroenterol Hepatol, 2022. PMID 35714859, Free PMC Article
  4. Inhibition of LDHA to induce eEF2 release enhances thrombocytopoiesis. Chen Q, et al. Blood, 2022 May 12. PMID 35176139
  5. Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH-A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR. Varma G, et al. NMR Biomed, 2021 Aug. PMID 34086382, Free PMC Article

See all (177) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Canonical Wnt signaling promotes HSC glycolysis and liver fibrosis through an LDH-A/HIF-1alpha transcriptional complex.
    Title: Canonical Wnt signaling promotes HSC glycolysis and liver fibrosis through an LDH-A/HIF-1α transcriptional complex.
  2. Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease.
    Title: Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease.
  3. STUB1 directs FOXQ1-mediated transactivation of Ldha gene and facilitates lactate production in mouse Sertoli cells.
    Title: STUB1 directs FOXQ1-mediated transactivation of Ldha gene and facilitates lactate production in mouse Sertoli cells.
  4. Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer.
    Title: Metabolic enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer.
  5. LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization.
    Title: LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by alleviating ROS and inducing M2 macrophage polarization.
  6. Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2.
    Title: Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2.
  7. Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development.
    Title: Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development.
  8. Lactate dehydrogenase regulates basal glucose uptake in adipocytes.
    Title: Lactate dehydrogenase regulates basal glucose uptake in adipocytes.
  9. Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function.
    Title: Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function.
  10. Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH-A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR.
    Title: Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH-A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-lactate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-lactate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-lactate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-lactate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD binding ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables lactate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lactate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in NAD metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glucose catabolic process to lactate via pyruvate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lactate biosynthetic process from pyruvate IC
Inferred by Curator
more info
 PubMed 
involved_in lactate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lactate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in liver development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in pyruvate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyruvate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyruvate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oxidoreductase complex ISO
Inferred from Sequence Orthology
more info
  
located_in sperm fibrous sheath IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
L-lactate dehydrogenase A chain
Names
LDH muscle subunit
LDH-M
M-LDH
lactate dehydrogenase 1, A chain
lactate dehydrogenase A4
NP_001129541.2
NP_034829.1
XP_030098036.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136069.2 → NP_001129541.2  L-lactate dehydrogenase A chain isoform 2

    See identical proteins and their annotated locations for NP_001129541.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon that results in a distinct 5' UTR and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AK150156, BC094428, BY195537
    Consensus CDS
    CCDS52255.1
    UniProtKB/TrEMBL
    A0A1B0GSX0, Q3TCI7, Q3THB4, Q3TI99
    Related
    ENSMUSP00000148107.2, ENSMUST00000209984.2
    Conserved Domains (2) summary
    cd05293
    Location:48 → 358
    LDH_1; A subgroup of L-lactate dehydrogenases
    TIGR01771
    Location:54 → 353
    L-LDH-NAD; L-lactate dehydrogenase

  2. NM_010699.2 → NP_034829.1  L-lactate dehydrogenase A chain isoform 1

    See identical proteins and their annotated locations for NP_034829.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (1).
    Source sequence(s)
    AC090123, BC094428, BY227595
    Consensus CDS
    CCDS21289.1
    UniProtKB/Swiss-Prot
    P06151
    UniProtKB/TrEMBL
    G5E8N5, Q3TCI7, Q3THB4, Q3TI99, Q564E2
    Related
    ENSMUSP00000036386.10, ENSMUST00000048209.16
    Conserved Domains (1) summary
    cd05293
    Location:19 → 329
    LDH_1; A subgroup of L-lactate dehydrogenases

RNA

  1. NR_102727.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK171373, AU079257, BC094428
    Related
    ENSMUST00000209548.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    46491698..46505051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242176.1 → XP_030098036.1  L-lactate dehydrogenase A chain isoform X1

    UniProtKB/Swiss-Prot
    P06151
    UniProtKB/TrEMBL
    G5E8N5, Q3TCI7, Q3THB4, Q3TI99, Q564E2
    Conserved Domains (1) summary
    cd05293
    Location:19 → 329
    LDH_1; A subgroup of L-lactate dehydrogenases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06151.3 GenPept UniProtKB/Swiss-Prot:P06151

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