Krt6a keratin 6A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt6aprovided by MGI
Official Full Name: keratin 6Aprovided by MGI
Primary source: MGI:MGI:1100845
See related: Ensembl:ENSMUSG00000058354 AllianceGenome:MGI:1100845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K6A; MK6a; CK-6A; K6[a]; mK6[a]; Krt2-6a; Krt2-6c; 2310016L08Rik
Summary: Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium; and wound healing. Acts upstream of or within Wnt signaling pathway; intermediate filament organization; and keratinization. Predicted to be located in keratin filament. Is expressed in alimentary system; epithelium; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in pachyonychia congenita. Orthologous to several human genes including KRT6A (keratin 6A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 14.8), CNS E18 (RPKM 5.0) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F2; 15 56.97 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101598363..101602746, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101689928..101694305, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings reveal that K6a/K6b modulate keratinocyte migration by regulating cell-matrix and cell-cell adhesion and highlight a role for keratins in collective cell migration.
Title: Keratin 6 regulates collective keratinocyte migration by altering cell-cell and cell-matrix adhesion.
mK6a and mK75 thus exhibit temporally distinct, and spatially opposed, expression patterns in the companion layer (Cl) during postnatal anagen.
Title: Keratin expression provides novel insight into the morphogenesis and function of the companion layer in hair follicles.
Although K6a was not essential for mammary gland development, loss of both K6a and K6b resulted in an increase in PR-positive mammary epithelial cells and decreased proliferation after exposure to steroid hormones
Title: Keratin 6 is not essential for mammary gland development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Krt2-6a (e-PCR), detects polymorphism
- UniSTS:265263

Krt6a (e-PCR), detects polymorphism
- UniSTS:547452

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intermediate filament organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within keratinization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within morphogenesis of an epithelium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: keratin, type II cytoskeletal 6A

Names: 60-kDa keratin; K6-alpha; cytokeratin-6A; keratin complex 2, basic, gene 6a; keratin complex 2, basic, gene 6c; keratin-6-alpha; mK6-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008476.4 → NP_032502.3 keratin, type II cytoskeletal 6A

See identical proteins and their annotated locations for NP_032502.3

Status: VALIDATED

Source sequence(s)

AC120787

Consensus CDS

CCDS27860.1

UniProtKB/Swiss-Prot

P50446, Q9Z331, Q9Z332

Related

ENSMUSP00000023788.7, ENSMUST00000023788.8

Conserved Domains (3) summary

pfam00038
Location:151 → 464

Filament; Intermediate filament protein

pfam16208
Location:15 → 148

Keratin_2_head; Keratin type II head

cl01888
Location:377 → 437

DUF883; Bacterial protein of unknown function (DUF883)