Krt4 keratin 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt4provided by MGI
Official Full Name: keratin 4provided by MGI
Primary source: MGI:MGI:96701
See related: Ensembl:ENSMUSG00000059668 AllianceGenome:MGI:96701
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K4; Krt2-4; Krt-2.4
Summary: Involved in epithelial cell differentiation and negative regulation of epithelial cell proliferation. Predicted to be located in cell surface and keratin filament. Is expressed in several structures, including alimentary system; lower urinary tract; sensory organ; skin; and trachea. Used to study hereditary mucosal leukokeratosis. Human ortholog(s) of this gene implicated in hereditary mucosal leukokeratosis. Orthologous to human KRT4 (keratin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 371.2), stomach adult (RPKM 351.0) and 1 other tissue See more
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Genomic context

Location:: 15 F2; 15 57.13 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101826970..101833170, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101918535..101924735, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Chemically induced (ENU) (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	ISO Inferred from Sequence Orthology more info
located_in keratin filament	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: keratin, type II cytoskeletal 4

Names: 57kDa keratin; 57kd keratin; CK-4; cytokeratin-4; cytoskeletal 57 kDa keratin; keratin complex 2, basic, gene 4; type-II keratin Kb4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008475.2 → NP_032501.2 keratin, type II cytoskeletal 4

See identical proteins and their annotated locations for NP_032501.2

Status: VALIDATED

Source sequence(s)

BC064008, BY139439

Consensus CDS

CCDS37222.1

UniProtKB/Swiss-Prot

A6H6D6, P07744, Q6P3F5

Related

ENSMUSP00000023797.7, ENSMUST00000023797.8

Conserved Domains (3) summary

pfam00038
Location:146 → 458

Filament; Intermediate filament protein

pfam16208
Location:14 → 142

Keratin_2_head; Keratin type II head

cl23720
Location:366 → 433

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)