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Krt84 keratin 84 [ Mus musculus (house mouse) ]

Gene ID: 16680, updated on 5-Mar-2024

Summary

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Official Symbol
Krt84provided by MGI
Official Full Name
keratin 84provided by MGI
Primary source
MGI:MGI:96700
See related
Ensembl:ENSMUSG00000044294 AllianceGenome:MGI:96700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HRb-1; Krt2-3; Krt2-16
Summary
A structural constituent of skin epidermis. Involved in regulation of keratinocyte differentiation. Located in intermediate filament cytoskeleton. Is expressed in filiform papillae and tongue. Orthologous to human KRT84 (keratin 84). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
15 F2; 15 56.9 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101433461..101441255, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101525026..101532820, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39797 Neighboring gene STARR-seq mESC enhancer starr_39798 Neighboring gene type II keratin Kb32P Neighboring gene predicted gene, 53914 Neighboring gene keratin 85 Neighboring gene STARR-seq mESC enhancer starr_39799 Neighboring gene keratin 82 Neighboring gene keratin 90

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The wound repair-associated keratins 6, 16, and 17. Insights into the role of intermediate filaments in specifying keratinocyte cytoarchitecture. McGowan K, et al. Subcell Biochem, 1998. PMID 9932493
  2. Structural features and sites of expression of a new murine 65 kD and 48 kD hair-related keratin pair, associated with a special type of parakeratotic epithelial differentiation. Tobiasch E, et al. Differentiation, 1992 Aug. PMID 1385239
  3. Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium. Jonker L, et al. Mech Dev, 2004 Nov. PMID 15454262
  4. Bcl11b/Ctip2 is required for development of lingual papillae in mice. Nishiguchi Y, et al. Dev Biol, 2016 Aug 1. PMID 27287879
  5. Hague (Hag). A new mouse hair mutation with an unstable semidominant allele. Poirier C, et al. Genetics, 2002 Oct. PMID 12399393, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84.
    Title: E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC140837

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of skin epidermis IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of keratinocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
keratin, type II cuticular Hb4
Names
65 kDa type II keratin
K84
keratin complex 2, basic, gene 16
keratin complex 2, gene 16
type II hair keratin Hb4
type-II keratin Kb24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008474.2 → NP_032500.2  keratin, type II cuticular Hb4

    See identical proteins and their annotated locations for NP_032500.2

    Status: VALIDATED

    Source sequence(s)
    AA738772, BC114971, BY779643, CF173770, CJ052880
    Consensus CDS
    CCDS27853.1
    UniProtKB/Swiss-Prot
    E9QMQ6, Q1RME6, Q61862, Q99M73
    Related
    ENSMUSP00000023720.8, ENSMUST00000023720.8
    Conserved Domains (4) summary
    pfam00038
    Location:173 → 483
    Filament; Intermediate filament protein
    pfam16208
    Location:16 → 169
    Keratin_2_head; Keratin type II head
    cl12013
    Location:217 → 372
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl23720
    Location:390 → 452
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    101433461..101441255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99M73.2 GenPept UniProtKB/Swiss-Prot:Q99M73

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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