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Krt36 keratin 36 [ Mus musculus (house mouse) ]

Gene ID: 16673, updated on 5-Mar-2024

Summary

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Official Symbol
Krt36provided by MGI
Official Full Name
keratin 36provided by MGI
Primary source
MGI:MGI:109364
See related
Ensembl:ENSMUSG00000020916 AllianceGenome:MGI:109364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K36; HRa-1; Krt1-5; MHRa-1; Krt1-22
Summary
A structural constituent of skin epidermis. Involved in regulation of keratinocyte differentiation. Located in intermediate filament cytoskeleton. Is expressed in filiform papillae and tongue. Orthologous to human KRT36 (keratin 36). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 2.2), subcutaneous fat pad adult (RPKM 0.7) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 63.41 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99992838..100000301, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100102012..100109487, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11571 Neighboring gene keratin 32 Neighboring gene STARR-seq mESC enhancer starr_30712 Neighboring gene keratin 35 Neighboring gene keratin 13 Neighboring gene keratin 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural features and sites of expression of a new murine 65 kD and 48 kD hair-related keratin pair, associated with a special type of parakeratotic epithelial differentiation. Tobiasch E, et al. Differentiation, 1992 Aug. PMID 1385239
  2. Regional regulation of Filiform tongue papillae development by Ikkα/Irf6. Kawasaki M, et al. Dev Dyn, 2016 Sep. PMID 27302476
  3. Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium. Jonker L, et al. Mech Dev, 2004 Nov. PMID 15454262
  4. WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Xu M, et al. Nat Commun, 2017 Jun 7. PMID 28589954, Free PMC Article
  5. DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis. Li Y, et al. Blood, 2021 Dec 9. PMID 34255829, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84.
    Title: E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of skin epidermis IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of keratinocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
is_active_in intermediate filament cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
keratin, type I cuticular Ha6
Names
keratin complex 1, acidic, gene 5
keratin-5
type I keratin 48 kDa (MHRa-1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001174099.1 → NP_001167570.1  keratin, type I cuticular Ha6

    See identical proteins and their annotated locations for NP_001167570.1

    Status: VALIDATED

    Source sequence(s)
    AL590873, AL662808
    Consensus CDS
    CCDS48929.1
    UniProtKB/Swiss-Prot
    B1AQ75, Q61861
    Related
    ENSMUSP00000103039.3, ENSMUST00000107416.3
    Conserved Domains (1) summary
    pfam00038
    Location:92 → 403
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    99992838..100000301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314302.2 → XP_017169791.1  keratin, type I cuticular Ha6 isoform X1

    UniProtKB/Swiss-Prot
    B1AQ75, Q61861
    Conserved Domains (1) summary
    pfam00038
    Location:92 → 403
    Filament; Intermediate filament protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_008472.2: Suppressed sequence

    Description
    NM_008472.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.

  2. NR_003957.1: Suppressed sequence

    Description
    NR_003957.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AQ75.1 GenPept UniProtKB/Swiss-Prot:B1AQ75

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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