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ADGRA3 adhesion G protein-coupled receptor A3 [ Homo sapiens (human) ]

Gene ID: 166647, updated on 3-Apr-2024

Summary

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Official Symbol
ADGRA3provided by HGNC
Official Full Name
adhesion G protein-coupled receptor A3provided by HGNC
Primary source
HGNC:HGNC:13839
See related
Ensembl:ENSG00000152990 MIM:612303; AllianceGenome:HGNC:13839
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR21; TEM5L; GPR125
Summary
This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in thyroid (RPKM 9.5), liver (RPKM 6.2) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
4p15.2
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (22387376..22516066, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (22369218..22497870, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (22388999..22517689, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124900841 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:22386916-22388115 Neighboring gene MPRA-validated peak5007 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:22524554-22525248 Neighboring gene microRNA 12115 Neighboring gene ribosomal protein S27 pseudogene 13 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:22626384-22627086 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:22627087-22627788 Neighboring gene glucosylceramidase beta 3 (gene/pseudogene) Neighboring gene CDC42 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Arrestin-independent constitutive endocytosis of GPR125/ADGRA3. Spiess K, et al. Ann N Y Acad Sci, 2019 Nov. PMID 31659746, Free PMC Article
  2. Elevated G-Protein Receptor 125 (GPR125) Expression Predicts Good Outcomes in Colorectal Cancer and Inhibits Wnt/β-Catenin Signaling Pathway. Wu Y, et al. Med Sci Monit, 2018 Sep 19. PMID 30231258, Free PMC Article
  3. Evaluation of candidate spermatogonial markers ID4 and GPR125 in testes of adult human cadaveric organ donors. Sachs C, et al. Andrology, 2014 Jul. PMID 24902969, Free PMC Article
  4. Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. Yamamoto Y, et al. Oncogene, 2004 May 13. PMID 15021905
  5. Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia. Christoforou A, et al. Mol Psychiatry, 2007 Nov. PMID 17457313

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data support that the constitutive internalization of GPR125 contributes to its biological functions by controlling receptor surface expression and accessibility for ligands
    Title: Arrestin-independent constitutive endocytosis of GPR125/ADGRA3.
  2. GPR125 overexpression inhibited the beta-catenin transcriptional activity, and down-regulated the expression levels of the Wnt downstream proteins-Axin2, c-Myc, cylinD1, and lef-1.
    Title: Elevated G-Protein Receptor 125 (GPR125) Expression Predicts Good Outcomes in Colorectal Cancer and Inhibits Wnt/β-Catenin Signaling Pathway.
  3. ID4 and GPR125 are expressed on partially overlapping spermatogonial populations and are more broadly expressed in normal adult human testis. ID4 and GPR125 could be used for identifying previously unrecognized human spermatogonial subpopulations
    Title: Evaluation of candidate spermatogonial markers ID4 and GPR125 in testes of adult human cadaveric organ donors.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
  5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ADGRA3 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor A3
Names
G-protein coupled receptor 125
probable G-protein coupled receptor 125

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032963.1 RefSeqGene

    Range
    4989..133679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_145290.4 → NP_660333.2  adhesion G protein-coupled receptor A3 precursor

    See identical proteins and their annotated locations for NP_660333.2

    Status: REVIEWED

    Source sequence(s)
    AC093814, AL832257, BC035645
    Consensus CDS
    CCDS33964.1
    UniProtKB/Swiss-Prot
    Q6UXK9, Q86SQ5, Q8IWK6, Q8TC55
    UniProtKB/TrEMBL
    B3KTN7, B4DRA3
    Related
    ENSP00000334952.5, ENST00000334304.10
    Conserved Domains (10) summary
    cd00096
    Location:262 → 337
    Ig; Immunoglobulin domain
    smart00082
    Location:189 → 223
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:249 → 341
    IG_like; Immunoglobulin like
    cd00116
    Location:70 → 182
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:83 → 106
    LRR_1; leucine-rich repeat [structural motif]
    pfam01825
    Location:704 → 743
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:363 → 416
    HRM; Hormone receptor domain
    pfam12799
    Location:107 → 146
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:85 → 141
    LRR_8; Leucine rich repeat
    cl21561
    Location:796 → 945
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    22387376..22516066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449703.1 → XP_047305659.1  adhesion G protein-coupled receptor A3 isoform X1

  2. XM_047449704.1 → XP_047305660.1  adhesion G protein-coupled receptor A3 isoform X1

    Related
    ENST00000282943.9

  3. XM_011513811.3 → XP_011512113.1  adhesion G protein-coupled receptor A3 isoform X2

    UniProtKB/TrEMBL
    B3KTN7, B4DRA3
    Conserved Domains (5) summary
    cd00096
    Location:36 → 111
    Ig; Immunoglobulin domain
    smart00410
    Location:23 → 115
    IG_like; Immunoglobulin like
    pfam01825
    Location:478 → 517
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:137 → 190
    HRM; Hormone receptor domain
    cl21561
    Location:570 → 719
    7tm_4; Olfactory receptor

  4. XM_005248137.6 → XP_005248194.1  adhesion G protein-coupled receptor A3 isoform X3

    Conserved Domains (9) summary
    cd00096
    Location:262 → 337
    Ig; Immunoglobulin domain
    smart00082
    Location:189 → 223
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:249 → 341
    IG_like; Immunoglobulin like
    cd00116
    Location:84 → 166
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:83 → 106
    LRR_1; leucine-rich repeat [structural motif]
    pfam01825
    Location:704 → 743
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:363 → 416
    HRM; Hormone receptor domain
    pfam12799
    Location:107 → 146
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:85 → 141
    LRR_8; Leucine rich repeat

RNA

  1. XR_007096381.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    22369218..22497870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349097.1 → XP_054205072.1  adhesion G protein-coupled receptor A3 isoform X1

  2. XM_054349096.1 → XP_054205071.1  adhesion G protein-coupled receptor A3 isoform X4

  3. XM_054349098.1 → XP_054205073.1  adhesion G protein-coupled receptor A3 isoform X2

  4. XM_054349099.1 → XP_054205074.1  adhesion G protein-coupled receptor A3 isoform X3

RNA

  1. XR_008486944.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IWK6.2 GenPept UniProtKB/Swiss-Prot:Q8IWK6

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