U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Krt14 keratin 14 [ Mus musculus (house mouse) ]

Gene ID: 16664, updated on 23-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Krt14provided by MGI
Official Full Name
keratin 14provided by MGI
Primary source
MGI:MGI:96688
See related
Ensembl:ENSMUSG00000045545 AllianceGenome:MGI:96688
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K14; CK-14; Krt1-14; Krt-1.14
Summary
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Biased expression in stomach adult (RPKM 89.1), limb E14.5 (RPKM 80.1) and 6 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 63.43 cM; 11 D
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100093988..100098336, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100203162..100207510, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39022 Neighboring gene keratin 9 Neighboring gene STARR-seq mESC enhancer starr_30714 Neighboring gene type I keratin KA11P Neighboring gene transcription elongation factor B (SIII), polypeptide 2 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Absence of keratin 1 restricts the course of infection with lymphocytic choriomeningitis virus strain MX. Labudová M, et al. Acta Virol, 2019. PMID 31230446
  2. A role for disulfide bonding in keratin intermediate filament organization and dynamics in skin keratinocytes. Feng X, et al. J Cell Biol, 2015 Apr 13. PMID 25869667, Free PMC Article
  3. Clinical, pathological and immunological features of psoriatic-like lesions affecting keratin 14-vascular endothelial growth factor transgenic mice. Canavese M, et al. Histol Histopathol, 2011 Mar. PMID 21210341
  4. An unexpected role for keratin 10 end domains in susceptibility to skin cancer. Chen J, et al. J Cell Sci, 2006 Dec 15. PMID 17118961
  5. beta-catenin-dependent and -independent effects of DeltaN-plakoglobin on epidermal growth and differentiation. Teulière J, et al. Mol Cell Biol, 2004 Oct. PMID 15367683, Free PMC Article

See all (565) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In vivo tracing of the Cytokeratin 14 lineages using self-cleaving guide RNAs and CRISPR/Cas9.
    Title: In vivo tracing of the Cytokeratin 14 lineages using self-cleaving guide RNAs and CRISPR/Cas9.
  2. Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells.
    Title: Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells.
  3. Expressions of cytokeratin 14 and proliferating cell nuclear antigen in the Hertwig's epithelial root sheath of a Vps4b knockout mouse.
    Title: Expressions of cytokeratin 14 and proliferating cell nuclear antigen in the Hertwig's epithelial root sheath of a Vps4b knockout mouse.
  4. Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3sigma and YAP1.
    Title: Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1.
  5. Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.
    Title: Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice.
  6. keratin 1 (K1) is essential for the persistent infection caused by LCMV strain MX, and its absence very effectively slows down the course of infection
    Title: Absence of keratin 1 restricts the course of infection with lymphocytic choriomeningitis virus strain MX.
  7. Cumulatively, these data indicate that altered CK14 (high) and CK18 (low) expression is perhaps an early event in bladder cancer tumorigenesis in females at least and is characteristic of both urothelial superficial pre-neoplastic and neoplastic lesions.
    Title: Differential expression of cytokeratin 14 and 18 in bladder cancer tumorigenesis.
  8. KRT14 is expressed in a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis.
    Title: KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis.
  9. CDK1, Aurora-B, and Rho-kinase phosphorylate keratin 5/14.
    Title: Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase.
  10. RA regulates Krt5 and Krt14 expression independently of stem cell character in developing salivary epithelium. The stem cell gene Kit is regulated inversely from Krt5/Krt14 by RA signaling.
    Title: Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables keratin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in hair cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in intermediate filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within keratinocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to radiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within stem cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in basal part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cornified envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intermediate filament ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in keratin filament IDA
Inferred from Direct Assay
more info
 PubMed 
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
keratin, type I cytoskeletal 14
Names
cytokeratin 14
keratin complex 1, acidic, gene 14

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313956.1 → NP_001300885.1  keratin, type I cytoskeletal 14 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AA050376, AA562488, AA612291, AI893364, AL590873
    Conserved Domains (2) summary
    pfam00038
    Location:120 → 370
    Filament; Intermediate filament protein
    cl19219
    Location:235 → 345
    DUF342; Protein of unknown function (DUF342)

  2. NM_001313957.1 → NP_001300886.1  keratin, type I cytoskeletal 14 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate first exon in place of that of variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (3) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA499338, AA562488, AA612291, AA760592, AI893364, AL590873
    UniProtKB/Swiss-Prot
    Q61781
    Related
    ENSMUST00000137265.2
    Conserved Domains (1) summary
    pfam00038
    Location:1 → 214
    Filament; Intermediate filament protein

  3. NM_016958.2 → NP_058654.1  keratin, type I cytoskeletal 14 isoform 1

    See identical proteins and their annotated locations for NP_058654.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA499338, AA562488, AA612291, AA760592, AI893364, AL590873
    Consensus CDS
    CCDS25413.1
    UniProtKB/Swiss-Prot
    A2A4G4, Q61781, Q91VQ4, Q99LE0
    Related
    ENSMUSP00000007272.8, ENSMUST00000007272.8
    Conserved Domains (1) summary
    pfam00038
    Location:120 → 431
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100093988..100098336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61781.2 GenPept UniProtKB/Swiss-Prot:Q61781

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous