Mafb MAF bZIP transcription factor B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mafbprovided by MGI
Official Full Name: MAF bZIP transcription factor Bprovided by MGI
Primary source: MGI:MGI:104555
See related: Ensembl:ENSMUSG00000074622 AllianceGenome:MGI:104555
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: kr; Krml; Krml1; Kreisler
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in abducens nerve formation; negative regulation of osteoclast differentiation; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; positive regulation of transcription by RNA polymerase II; and respiratory gaseous exchange by respiratory system. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and urinary system. Used to study Duane retraction syndrome and multicentric carpotarsal osteolysis syndrome. Human ortholog(s) of this gene implicated in Duane retraction syndrome and multicentric carpotarsal osteolysis syndrome. Orthologous to human MAFB (MAF bZIP transcription factor B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 2 H2; 2 80.92 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (160205597..160208985, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (160363677..160367065, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MafB regulates NLRP3 inflammasome activation by sustaining p62 expression in macrophages.
Title: MafB regulates NLRP3 inflammasome activation by sustaining p62 expression in macrophages.
MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation.
Title: MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation.
MafB-dependent neurotransmitter signaling promotes beta cell migration in the developing pancreas.
Title: MafB-dependent neurotransmitter signaling promotes β cell migration in the developing pancreas.
Macrophage-Specific, Mafb-Deficient Mice Showed Delayed Skin Wound Healing.
Title: Macrophage-Specific, Mafb-Deficient Mice Showed Delayed Skin Wound Healing.
MafB Maintains beta-Cell Identity under MafA-Deficient Conditions.
Title: MafB Maintains β-Cell Identity under MafA-Deficient Conditions.
The Mafb cleft-associated variant H131Q is not required for palatogenesis in the mouse.
Title: The Mafb cleft-associated variant H131Q is not required for palatogenesis in the mouse.
Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesisdagger.
Title: Loss of Mafb and Maf distorts myeloid cell ratios and disrupts fetal mouse testis vascularization and organogenesis†.
Radiation inducible MafB gene is required for thymic regeneration.
Title: Radiation inducible MafB gene is required for thymic regeneration.
MAFB modulates the maturation of lymphatic vascular networks in mice.
Title: MAFB modulates the maturation of lymphatic vascular networks in mice.
Transcription factor MafB in podocytes protects against the development of focal segmental glomerulosclerosis.
Title: Transcription factor MafB in podocytes protects against the development of focal segmental glomerulosclerosis.

Submit: New GeneRIF Correction See all GeneRIFs (91)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Chemically induced (ENU) (1) 1 citation
Radiation induced (1)
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mafb (e-PCR), detects polymorphism
- UniSTS:526088

PMC180917P2 (e-PCR)
- UniSTS:271670

UniSTS:234569 (e-PCR)
- UniSTS:234569

Emv15 (e-PCR), detects polymorphism
- UniSTS:142985

RH94703 (e-PCR)
- UniSTS:119950

Mafb (e-PCR), detects polymorphism
- UniSTS:547258

G06850 (e-PCR)
- UniSTS:13012

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in abducens nerve formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cornified envelope assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of myeloid cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhombomere 5 development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhombomere 6 development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within segment specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thymus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor MafB

Names: Kreisler (maf-related) leucine zipper protein; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B; maf-B; segmentation protein Kr; transcription factor Maf-1; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010658.3 → NP_034788.1 transcription factor MafB

See identical proteins and their annotated locations for NP_034788.1

Status: VALIDATED

Source sequence(s)

AK132425, AL591665

Consensus CDS

CCDS16994.1

UniProtKB/Swiss-Prot

P54841, Q3U3C8, Q3UPT9

Related

ENSMUSP00000096728.4, ENSMUST00000099126.5

Conserved Domains (2) summary

cd14718
Location:233 → 302

bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

pfam08383
Location:80 → 113

Maf_N; Maf N-terminal region