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Kras Kirsten rat sarcoma viral oncogene homolog [ Mus musculus (house mouse) ]

Gene ID: 16653, updated on 16-Apr-2024

Summary

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Official Symbol
Krasprovided by MGI
Official Full Name
Kirsten rat sarcoma viral oncogene homologprovided by MGI
Primary source
MGI:MGI:96680
See related
Ensembl:ENSMUSG00000030265 AllianceGenome:MGI:96680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; c-Ki-ras
Summary
Enables GTPase activity. Involved in endocrine signaling. Acts upstream of or within several processes, including forebrain astrocyte development; modulation of chemical synaptic transmission; and positive regulation of Rac protein signal transduction. Located in membrane. Is expressed in several structures, including brain; early embryo; eye; genitourinary system; and gut. Used to study several diseases, including Noonan syndrome 3; carcinoma (multiple); juvenile myelomonocytic leukemia; lung cancer; and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 17.0), whole brain E14.5 (RPKM 16.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G3; 6 77.37 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (145162425..145197631, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (145216699..145250420, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2809 Neighboring gene STARR-positive B cell enhancer mm9_chr6:145072197-145072498 Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E4880 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene predicted gene 15543 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene STARR-seq mESC enhancer starr_17780 Neighboring gene predicted gene 15706 Neighboring gene ribosomal protein S25, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_17782 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:145252111-145252451 Neighboring gene lactate dehydrogenase A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D. Johnson CW, et al. Cell Rep, 2019 Aug 6. PMID 31390567, Free PMC Article
  2. A Peptide Probe Enables Photoacoustic-Guided Imaging and Drug Delivery to Lung Tumors in K-ras(LA2) Mutant Mice. Jung H, et al. Cancer Res, 2019 Aug 15. PMID 31243044
  3. The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice. Engle DD, et al. Science, 2019 Jun 21. PMID 31221853, Free PMC Article
  4. Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias. Huang BJ, et al. PLoS Genet, 2019 Jun. PMID 31199785, Free PMC Article
  5. Rigosertib ameliorates the effects of oncogenic KRAS signaling in a murine model of myeloproliferative neoplasia. Baker SJ, et al. Oncotarget, 2019 Mar 8. PMID 30956775, Free PMC Article

See all (1200) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oncogenic K-Ras[G12V] cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts.
    Title: Oncogenic K-Ras(G12V) cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts.
  2. Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
    Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
  3. Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras[G12D]-driven tumors.
    Title: Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras(G12D)-driven tumors.
  4. Exploring the role of sporadic BRAF and KRAS mutations during colorectal cancer pathogenesis: A spotlight on the contribution of the endosome-lysosome system.
    Title: Exploring the role of sporadic BRAF and KRAS mutations during colorectal cancer pathogenesis: A spotlight on the contribution of the endosome-lysosome system.
  5. Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15.
    Title: Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15.
  6. Mutant KRAS-activated circATXN7 fosters tumor immunoescape by sensitizing tumor-specific T cells to activation-induced cell death.
    Title: Mutant KRAS-activated circATXN7 fosters tumor immunoescape by sensitizing tumor-specific T cells to activation-induced cell death.
  7. KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo.
    Title: KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo.
  8. Alveolar type I cells can give rise to KRAS-induced lung adenocarcinoma.
    Title: Alveolar type I cells can give rise to KRAS-induced lung adenocarcinoma.
  9. Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression.
    Title: Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression.
  10. Single-Cell Analysis Differentiates the Effects of p53 Mutation and p53 Loss on Cell Compositions of Oncogenic Kras-Driven Pancreatic Cancer.
    Title: Single-Cell Analysis Differentiates the Effects of p53 Mutation and p53 Loss on Cell Compositions of Oncogenic Kras-Driven Pancreatic Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (463)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7141

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GMP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
enables LRR domain binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein-membrane adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of Rac protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within Ras protein signal transduction TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within forebrain astrocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of glial cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of Rac protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of glial cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within skeletal muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within striated muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of type I pneumocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within visual learning IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
GTPase KRas
Names
Kirsten rat sarcoma oncogene 2, expressed
p21 protein
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
NP_001390169.1
NP_001390170.1
NP_001390171.1
NP_001390172.1
NP_001390173.1
NP_001390174.1
NP_001390175.1
NP_067259.4
XP_006506982.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403240.1 → NP_001390169.1  GTPase KRas isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157091
    UniProtKB/TrEMBL
    Q5J7N1

  2. NM_001403241.1 → NP_001390170.1  GTPase KRas isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157091
    UniProtKB/TrEMBL
    Q5J7N1

  3. NM_001403242.1 → NP_001390171.1  GTPase KRas isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157091
    UniProtKB/TrEMBL
    Q5J7N1

  4. NM_001403243.1 → NP_001390172.1  GTPase KRas isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157091
    UniProtKB/Swiss-Prot
    P04200, P08643, P32883
    UniProtKB/TrEMBL
    Q0VDV7
    Related
    ENSMUSP00000107339.2, ENSMUST00000111710.8

  5. NM_001403244.1 → NP_001390173.1  GTPase KRas isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157091

  6. NM_001403245.1 → NP_001390174.1  GTPase KRas isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157091

  7. NM_001403246.1 → NP_001390175.1  GTPase KRas isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157091
    UniProtKB/TrEMBL
    A0A0N4SVY1
    Related
    ENSMUSP00000145294.2, ENSMUST00000203147.3

  8. NM_021284.7 → NP_067259.4  GTPase KRas isoform 1

    See identical proteins and their annotated locations for NP_067259.4

    Status: VALIDATED

    Source sequence(s)
    AC157091
    Consensus CDS
    CCDS20693.1
    UniProtKB/TrEMBL
    Q3U2W7, Q5J7N1
    Related
    ENSMUSP00000032399.6, ENSMUST00000032399.12
    Conserved Domains (2) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    smart00010
    Location:16 → 166
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

RNA

  1. NR_175367.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157091

  2. NR_175368.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157091

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    145162425..145197631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506919.5 → XP_006506982.1  GTPase KRas isoform X2

    See identical proteins and their annotated locations for XP_006506982.1

    UniProtKB/TrEMBL
    Q3U2W7
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32883.1 GenPept UniProtKB/Swiss-Prot:P32883

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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