U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kpna6 karyopherin subunit alpha 6 [ Mus musculus (house mouse) ]

Gene ID: 16650, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Kpna6provided by MGI
Official Full Name
karyopherin subunit alpha 6provided by MGI
Primary source
MGI:MGI:1100836
See related
Ensembl:ENSMUSG00000003731 AllianceGenome:MGI:1100836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IPOA7; Kpna5; NPI-2
Summary
Enables nuclear import signal receptor activity. Acts upstream of or within several processes, including entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of macromolecule metabolic process; and protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in several structures, including heart; liver; lung; oocyte; and spleen. Orthologous to human KPNA6 (karyopherin subunit alpha 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 30.4), subcutaneous fat pad adult (RPKM 16.8) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 D2.2; 4 63.28 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129537772..129566560, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129643979..129672767, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10261 Neighboring gene STARR-seq mESC enhancer starr_11504 Neighboring gene coiled coil domain containing 28B Neighboring gene predicted gene, 34305 Neighboring gene taxilin alpha Neighboring gene STARR-positive B cell enhancer ABC_E1283 Neighboring gene STARR-positive B cell enhancer ABC_E7992 Neighboring gene transmembrane protein 39b Neighboring gene microRNA 7016 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129378925-129379108 Neighboring gene KH domain containing, RNA binding, signal transduction associated 1 Neighboring gene STARR-seq mESC enhancer starr_11505

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis. Liu N, et al. Development, 2021 Oct 1. PMID 34473250, Free PMC Article
  2. Importin-α7 Is Involved in the Formation of Ebola Virus Inclusion Bodies but Is Not Essential for Pathogenicity in Mice. Gabriel G, et al. J Infect Dis, 2015 Oct 1. PMID 26185094, Free PMC Article
  3. Importin-α7 is required for enhanced influenza A virus replication in the alveolar epithelium and severe lung damage in mice. Resa-Infante P, et al. J Virol, 2014 Jul. PMID 24829333, Free PMC Article
  4. Identification of importin α 7 specific transport cargoes using a proteomic screening approach. Hügel S, et al. Mol Cell Proteomics, 2014 May. PMID 24623588, Free PMC Article
  5. Involvement of classical bipartite/karyopherin nuclear import pathway components in acrosomal trafficking and assembly during bovine and murid spermiogenesis. Tran MH, et al. Biol Reprod, 2012 Mar. PMID 22156475

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis.
    Title: Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis.
  2. Data shows that Importin 7 binds many partners from ovary that alpha are involved in RNA processing, chromosome organization, and chromatin modification.
    Title: Identification of importin α 7 specific transport cargoes using a proteomic screening approach.
  3. Importin alpha7 is a new member of the small group of maternal effect genes.
    Title: Importin α7 is essential for zygotic genome activation and early mouse development.
  4. Overexpression of Kpna6 facilitates Keap1 nuclear import and attenuates Nrf2 signaling, whereas knockdown of Kpna6 slows down Keap1 nuclear import and enhances the Nrf2-mediated adaptive response induced by oxidative stress.
    Title: KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear import signal receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within entry of viral genome into host nucleus through nuclear pore complex via importin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within entry of viral genome into host nucleus through nuclear pore complex via importin ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within maternal process involved in female pregnancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of viral life cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of viral life cycle ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within symbiont-mediated perturbation of host defenses IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within viral genome replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NLS-dependent protein nuclear import complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
importin subunit alpha-7
Names
importin alpha 7
importin alpha-S2
karyopherin (importin) alpha 5
karyopherin (importin) alpha 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008468.4 → NP_032494.3  importin subunit alpha-7

    See identical proteins and their annotated locations for NP_032494.3

    Status: VALIDATED

    Source sequence(s)
    AK046371, AL671759, CJ082540
    Consensus CDS
    CCDS18701.1
    UniProtKB/Swiss-Prot
    O35345, Q3U388, Q9CVP9
    UniProtKB/TrEMBL
    Q4FJZ2, Q8BH30
    Related
    ENSMUSP00000099650.5, ENSMUST00000102590.11
    Conserved Domains (5) summary
    COG5064
    Location:36 → 525
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:251 → 365
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam01749
    Location:9 → 102
    IBB; Importin beta binding domain
    pfam16186
    Location:464 → 508
    Arm_3; Atypical Arm repeat
    sd00043
    Location:254 → 279
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    129537772..129566560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502814.4 → XP_006502877.1  importin subunit alpha-7 isoform X1

    See identical proteins and their annotated locations for XP_006502877.1

    UniProtKB/TrEMBL
    Q4FJZ2
    Related
    ENSMUSP00000003828.5, ENSMUST00000003828.11
    Conserved Domains (2) summary
    COG5064
    Location:41 → 530
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:259 → 284
    ARM; armadillo repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35345.2 GenPept UniProtKB/Swiss-Prot:O35345

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous