Kng1 kininogen 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kng1provided by MGI
Official Full Name: kininogen 1provided by MGI
Primary source: MGI:MGI:1097705
See related: Ensembl:ENSMUSG00000022875 AllianceGenome:MGI:1097705
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kng
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity; protease binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; negative regulation of blood coagulation; and negative regulation of endopeptidase activity. Predicted to act upstream of or within several processes, including blood coagulation; negative regulation of peptidase activity; and vasodilation. Located in collagen-containing extracellular matrix. Is expressed in yolk sac. Human ortholog(s) of this gene implicated in high molecular weight kininogen deficiency. Orthologous to human KNG1 (kininogen 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 646.0), liver adult (RPKM 179.1) and 3 other tissues See more
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Genomic context

Location:: 16 B1; 16 13.88 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (22876970..22900828)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (23058220..23082078)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure.
Title: Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure.
Overexpression of Kininogen-1 aggravates oxidative stress and mitochondrial dysfunction in DOX-induced cardiotoxicity.
Title: Overexpression of Kininogen-1 aggravates oxidative stress and mitochondrial dysfunction in DOX-induced cardiotoxicity.
Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis.
Title: Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis.
Schistosome tegument contains two cysteine proteases belonging to the calpain family (SmCalp1 and SmCalp2) and these are likely responsible for the high molecular weight kininogen (HK) cleavage reported here. Schistosome cleavage of HK should help impede blood clotting and inflammation around the worms in vivo and so promote their ease of movement within the vasculature of their hosts.
Title: The blood fluke Schistosoma mansoni cleaves the coagulation protein high molecular weight kininogen (HK) but does not generate the vasodilator bradykinin.
uPAR mediates efferocytosis through high molecular weight kininogen interaction with phosphatidylserine on apoptotic cells
Title: High molecular weight kininogen binds phosphatidylserine and opsonizes urokinase plasminogen activator receptor-mediated efferocytosis.
mice deficient in KNG showed less severe blood-brain barrier damage and edema formation, and the local inflammatory response was reduced compared with controls.
Title: Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation.
The vascular compartment is the main site of AngI and bradykinin-(1-9) formation and metabolism.
Title: Genetic models provide unique insight into angiotensin and bradykinin peptides in the extravascular compartment of the heart in vivo.
mKng1 is responsible for production of plasma kininogen
Title: Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis.
Domain 5 of kininogen was identified as an anti-adhesive component with a potent anti-inflammatory action in a peritonitis mouse model.
Title: Haemostatic factors occupy new territory: the role of the urokinase receptor system and kininogen in inflammation.
Two genes, kininogen-I and kininogen-II, are located in close proximity on chromosome 16 in a head-to-head arrangement. In liver and kidney, both genes are expressed and for each gene three alternative splice variants are synthesized.
Title: Structure and expression of two kininogen genes in mice.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17999 (e-PCR)
- UniSTS:124760

NoName (e-PCR)
- UniSTS:489569

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kininogen-1

Names: H-kininigen; L-kininogen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102411.1 → NP_001095881.1 kininogen-1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001095881.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as HMW kininogen-I.

Source sequence(s)

AC154540, BC108936

Consensus CDS

CCDS49804.1

UniProtKB/Swiss-Prot

O08676, O08677, Q32MX7, Q6S9I1, Q91XK5

UniProtKB/TrEMBL

A0A0R4J038

Related

ENSMUSP00000023589.9, ENSMUST00000023589.15

Conserved Domains (1) summary

smart00043
Location:263 → 370

CY; Cystatin-like domain
NM_001102412.1 → NP_001095882.1 kininogen-1 isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AA277668, AC154540, AK005547

Consensus CDS

CCDS49803.1

UniProtKB/TrEMBL

D3YTY9

Related

ENSMUSP00000087346.7, ENSMUST00000089902.8

Conserved Domains (1) summary

smart00043
Location:263 → 370

CY; Cystatin-like domain
NM_001425115.1 → NP_001412044.1 kininogen-1 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC154540
NM_023125.3 → NP_075614.1 kininogen-1 isoform 2 precursor

See identical proteins and their annotated locations for NP_075614.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2), also known as LMW kininogen-I, has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC154540, AK005547, BY463622

Consensus CDS

CCDS28073.1

UniProtKB/Swiss-Prot

O08677

Related

ENSMUSP00000040485.7, ENSMUST00000039492.14

Conserved Domains (1) summary

smart00043
Location:263 → 370

CY; Cystatin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

22876970..22900828

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521813.1 → XP_006521876.1 kininogen-1 isoform X3

Conserved Domains (1) summary

smart00043
Location:263 → 370

CY; Cystatin-like domain
XM_006521812.3 → XP_006521875.1 kininogen-1 isoform X1

Conserved Domains (1) summary

smart00043
Location:141 → 284

CY; Cystatin-like domain