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Kng1 kininogen 1 [ Mus musculus (house mouse) ]

Gene ID: 16644, updated on 9-Dec-2024

Summary

Official Symbol
Kng1provided by MGI
Official Full Name
kininogen 1provided by MGI
Primary source
MGI:MGI:1097705
See related
Ensembl:ENSMUSG00000022875 AllianceGenome:MGI:1097705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kng
Summary
Predicted to enable cysteine-type endopeptidase inhibitor activity; hormone activity; and protease binding activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; negative regulation of blood coagulation; and vasodilation. Located in collagen-containing extracellular matrix. Is expressed in yolk sac. Human ortholog(s) of this gene implicated in hereditary angioedema and high molecular weight kininogen deficiency. Orthologous to human KNG1 (kininogen 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in liver E18 (RPKM 646.0), liver adult (RPKM 179.1) and 3 other tissues See more
Orthologs
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Genomic context

See Kng1 in Genome Data Viewer
Location:
16 B1; 16 13.88 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22876970..22900828)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (23058220..23082078)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene tryptophan rich basic protein pseudogene Neighboring gene ribosomal protein S3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40426 Neighboring gene STARR-seq mESC enhancer starr_40430 Neighboring gene AT rich interactive domain 1A (SWI-like) pseudogene Neighboring gene predicted gene, 30693 Neighboring gene STARR-seq mESC enhancer starr_40432 Neighboring gene eukaryotic translation initiation factor 4A2 Neighboring gene small nucleolar RNA, C/D box 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC123437

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity  
enables cysteine-type endopeptidase inhibitor activity  
enables cysteine-type endopeptidase inhibitor activity  
enables hormone activity  
enables protease binding  
enables signaling receptor binding  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix PubMed 
is_active_in extracellular region  
located_in extracellular region  
located_in extracellular space  
located_in perikaryon  

General protein information

Preferred Names
kininogen-1
Names
H-kininigen
L-kininogen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102411.1NP_001095881.1  kininogen-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001095881.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as HMW kininogen-I.
    Source sequence(s)
    AC154540, BC108936
    Consensus CDS
    CCDS49804.1
    UniProtKB/Swiss-Prot
    O08676, O08677, Q32MX7, Q6S9I1, Q91XK5
    UniProtKB/TrEMBL
    A0A0R4J038
    Related
    ENSMUSP00000023589.9, ENSMUST00000023589.15
    Conserved Domains (1) summary
    smart00043
    Location:263370
    CY; Cystatin-like domain
  2. NM_001102412.1NP_001095882.1  kininogen-1 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA277668, AC154540, AK005547
    Consensus CDS
    CCDS49803.1
    UniProtKB/TrEMBL
    D3YTY9
    Related
    ENSMUSP00000087346.7, ENSMUST00000089902.8
    Conserved Domains (1) summary
    smart00043
    Location:263370
    CY; Cystatin-like domain
  3. NM_001425115.1NP_001412044.1  kininogen-1 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC154540
  4. NM_023125.3NP_075614.1  kininogen-1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_075614.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2), also known as LMW kininogen-I, has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154540, AK005547, BY463622
    Consensus CDS
    CCDS28073.1
    UniProtKB/Swiss-Prot
    O08677
    Related
    ENSMUSP00000040485.7, ENSMUST00000039492.14
    Conserved Domains (1) summary
    smart00043
    Location:263370
    CY; Cystatin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    22876970..22900828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521813.1XP_006521876.1  kininogen-1 isoform X3

    Conserved Domains (1) summary
    smart00043
    Location:263370
    CY; Cystatin-like domain
  2. XM_006521812.3XP_006521875.1  kininogen-1 isoform X1

    Conserved Domains (1) summary
    smart00043
    Location:141284
    CY; Cystatin-like domain
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