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Klrc2 killer cell lectin-like receptor subfamily C, member 2 [ Mus musculus (house mouse) ]

Gene ID: 16642, updated on 30-Apr-2024

Summary

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Official Symbol
Klrc2provided by MGI
Official Full Name
killer cell lectin-like receptor subfamily C, member 2provided by MGI
Primary source
MGI:MGI:1336162
See related
Ensembl:ENSMUSG00000052736 AllianceGenome:MGI:1336162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NKG2C
Summary
Predicted to enable MHC class I protein complex binding activity; activating MHC class Ib receptor activity; and protein antigen binding activity. Predicted to be involved in natural killer cell mediated immunity; positive regulation of natural killer cell degranulation; and stimulatory C-type lectin receptor signaling pathway. Located in external side of plasma membrane. Orthologous to human KLRC2 (killer cell lectin like receptor C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
6 F3; 6 63.44 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129626565..129637700, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129649602..129660737, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor subfamily K, member 1 Neighboring gene killer cell lectin-like receptor subfamily C, member 3 Neighboring gene killer cell lectin-like receptor subfamily C, member 1 Neighboring gene PQ loop repeat containing pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning of mouse NKG2A and C. Silver ET, et al. Immunogenetics, 1999 Jul. PMID 10369936
  2. Cloning of murine NKG2A, B and C: second family of C-type lectin receptors on murine NK cells. Lohwasser S, et al. Eur J Immunol, 1999 Mar. PMID 10092077
  3. Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing. Ferez M, et al. J Exp Med, 2021 May 3. PMID 33765134, Free PMC Article
  4. Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. Vance RE, et al. J Exp Med, 1999 Dec 20. PMID 10601355, Free PMC Article
  5. Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity. Saether PC, et al. J Immunol, 2011 Dec 15. PMID 22084441

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rat and mouse CD94/NKG2C heterodimers bind efficiently to both adadptor proteins DAP12 and DAP10; this binding activity is critically dependent on the transmembrane lysine residue of CD94.
    Title: Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class I protein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables activating MHC class Ib receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein antigen binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of natural killer cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of natural killer cell activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in stimulatory C-type lectin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
killer cell lectin-like receptor subfamily C, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098669.1 → NP_001092139.1  killer cell lectin-like receptor subfamily C, member 2 isoform 2

    See identical proteins and their annotated locations for NP_001092139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is missing one of the internal coding exons found in transcript variant 1. It maintains the same reading frame, and encodes a shorter isoform (2, also known as NKG2C2) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AF106011
    Consensus CDS
    CCDS51924.1
    UniProtKB/TrEMBL
    D3YXP2, Q9WVJ7
    Related
    ENSMUSP00000113970.2, ENSMUST00000118401.8
    Conserved Domains (2) summary
    cd03593
    Location:97 → 209
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    PHA03097
    Location:65 → 212
    PHA03097; C-type lectin-like protein; Provisional

  2. NM_010653.4 → NP_034783.3  killer cell lectin-like receptor subfamily C, member 2 isoform 1

    See identical proteins and their annotated locations for NP_034783.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1, also known as NKG2C1).
    Source sequence(s)
    AF109785
    Consensus CDS
    CCDS51925.1
    UniProtKB/TrEMBL
    D3YXP2, Q9WTJ9
    Related
    ENSMUSP00000112733.2, ENSMUST00000119533.2
    Conserved Domains (1) summary
    cd03593
    Location:122 → 234
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    129626565..129637700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165892.1 → XP_036021785.1  killer cell lectin-like receptor subfamily C, member 2 isoform X2

    UniProtKB/TrEMBL
    D3YXP2, Q9WTJ9
    Related
    ENSMUSP00000107688.3, ENSMUST00000112057.9
    Conserved Domains (1) summary
    cd03593
    Location:122 → 234
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  2. XM_017321419.1 → XP_017176908.1  killer cell lectin-like receptor subfamily C, member 2 isoform X1

    UniProtKB/TrEMBL
    A1L3Q6
    Related
    ENSMUSP00000071813.5, ENSMUST00000071920.11
    Conserved Domains (1) summary
    cd03593
    Location:130 → 242
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
Nucleotide Protein Strain
Heading Accession and Version

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