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Klra7 killer cell lectin-like receptor, subfamily A, member 7 [ Mus musculus (house mouse) ]

Gene ID: 16638, updated on 8-Feb-2024

Summary

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Official Symbol
Klra7provided by MGI
Official Full Name
killer cell lectin-like receptor, subfamily A, member 7provided by MGI
Primary source
MGI:MGI:101901
See related
Ensembl:ENSMUSG00000067599 AllianceGenome:MGI:101901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LGL-1; Ly49g; Ly49g1; Ly49g2; Ly49G.4; Ly-49G.1; Ly-49G.2; Ly-49G.3
Summary
Predicted to enable carbohydrate binding activity. Predicted to act upstream of or within cell adhesion. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
6 F3; 6 63.44 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (130195568..130210285, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (130218605..130233322, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23552 Neighboring gene killer cell lectin-like receptor subfamily A, member 9 Neighboring gene predicted gene, 52487 Neighboring gene killer cell lectin-like receptor subfamily A, member 10 Neighboring gene killer cell lectin-like receptor subfamily A, member 13, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MHC class I D(k) expression in hematopoietic and nonhematopoietic cells confers natural killer cell resistance to murine cytomegalovirus. Xie X, et al. Proc Natl Acad Sci U S A, 2010 May 11. PMID 20421478, Free PMC Article
  2. Allelic variation in the ectodomain of the inhibitory Ly-49G2 receptor alters its specificity for allogeneic and xenogeneic ligands. Silver ET, et al. J Immunol, 2002 Nov 1. PMID 12391184
  3. Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2). Mason LH, et al. J Exp Med, 1995 Aug 1. PMID 7629495, Free PMC Article
  4. LGL-1: a potential triggering molecule on murine NK cells. Mason LH, et al. J Leukoc Biol, 1994 Mar. PMID 7509843
  5. The activating Ly49W and inhibitory Ly49G NK cell receptors display similar affinities for identical MHC class I ligands. Ma BJ, et al. Immunogenetics, 2014 Aug. PMID 24797174

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ectodomain of inhibitory Ly49G of the BALB/c mouse strain is highly similar to the Ly49W activating receptor in the nonobese diabetic (NOD) mouse.
    Title: The activating Ly49W and inhibitory Ly49G NK cell receptors display similar affinities for identical MHC class I ligands.
  2. High levels of Ly49G2 have a dominant inhibitory effect on Ly49D expressed at low levels on immature bone marrow and mature B cells, resulting in inhibition of interferon-gamma secretion.
    Title: Tight regulation of IFN-gamma transcription and secretion in immature and mature B cells by the inhibitory MHC class I receptor, Ly49G2.
  3. Allelic variation in Ly-49G2 extracellular domains has functional significance by altering Ly-49 receptor specificity for class I MHC and xenogeneic ligands.
    Title: Allelic variation in the ectodomain of the inhibitory Ly-49G2 receptor alters its specificity for allogeneic and xenogeneic ligands.
  4. Glycosylation of Ly-49G2 at amino acid residues NTT221-23 reduces receptor binding to H-2Dd tetramers and may represent a mechanism by which natural killer cells regulate affinity for host class I ligands.
    Title: Receptor glycosylation regulates Ly-49 binding to MHC class I.
  5. The repertoire of inhibitory Ly49 receptors may be formed under the influenced of Fyn-dependent NK cell activation as well as the respective MHC class I environment.
    Title: A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC123448, MGC161317

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
killer cell lectin-like receptor 7
Names
T-cell surface glycoprotein Ly-49G
ly-49g
lymphocyte antigen 49g

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110323.1 → NP_001103793.1  killer cell lectin-like receptor 7 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC161448, U10093
    Consensus CDS
    CCDS51928.1
    UniProtKB/Swiss-Prot
    Q60654, Q60655, Q60656, Q60683
    UniProtKB/TrEMBL
    F8WJ94
    Related
    ENSMUSP00000032286.7, ENSMUST00000032286.7
    Conserved Domains (2) summary
    cd03593
    Location:158 → 273
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:40 → 171
    Ly49; Ly49-like protein, N-terminal region

  2. NM_014194.5 → NP_055009.5  killer cell lectin-like receptor 7 isoform 2

    See identical proteins and their annotated locations for NP_055009.5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' and 3' UTR and lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    U10094
    Consensus CDS
    CCDS39668.1
    UniProtKB/TrEMBL
    Q9EP76
    Related
    ENSMUSP00000037917.8, ENSMUST00000049304.14
    Conserved Domains (2) summary
    cd03593
    Location:145 → 260
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:40 → 158
    Ly49; Ly49-like protein, N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    130195568..130210285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60654.1 GenPept UniProtKB/Swiss-Prot:Q60654

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