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Klra2 killer cell lectin-like receptor, subfamily A, member 2 [ Mus musculus (house mouse) ]

Gene ID: 16633, updated on 8-Feb-2024

Summary

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Official Symbol
Klra2provided by MGI
Official Full Name
killer cell lectin-like receptor, subfamily A, member 2provided by MGI
Primary source
MGI:MGI:101906
See related
Ensembl:ENSMUSG00000030187 AllianceGenome:MGI:101906
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly49b; Klra30
Summary
The gene is a member of the large lectin-like type 2 transmembrane receptor family of the natural killer gene complex. The gene is located distantly telomeric to its family's gene cluster on chromosome 6. The gene differs from the other genes in its cluster as its promoter region contains long and short interspersed repetitive elements suggesting a possible rearrangement or gene conversion. It is unknown whether this gene's encoded protein is involved with natural killer cell differentiation as are its other family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Klra2 in Genome Data Viewer
Location:
6 F3; 6 63.44 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (131196190..131224679, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (131198970..131247716, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 239-like Neighboring gene predicted gene, 57775 Neighboring gene STARR-seq mESC enhancer starr_17492 Neighboring gene predicted gene 5582 Neighboring gene STARR-positive B cell enhancer ABC_E9280 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:131243245-131243354 Neighboring gene mago homolog B, exon junction complex core component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutagenesis of Ly49B reveals key structural elements required for promiscuous binding to MHC class I molecules and new insights into the molecular evolution of Ly49s. Mickiewicz KM, et al. J Immunol, 2014 Feb 15. PMID 24403531
  2. Ly49B is expressed on multiple subpopulations of myeloid cells. Gays F, et al. J Immunol, 2006 Nov 1. PMID 17056508
  3. Orderly and nonstochastic acquisition of CD94/NKG2 receptors by developing NK cells derived from embryonic stem cells in vitro. Lian RH, et al. J Immunol, 2002 May 15. PMID 11994449
  4. Comparative analysis of the promoter regions and transcriptional start sites of mouse Ly49 genes. Wilhelm BT, et al. Immunogenetics, 2001 Apr. PMID 11398966
  5. Interactions of Ly49 family receptors with MHC class I ligands in trans and cis. Scarpellino L, et al. J Immunol, 2007 Feb 1. PMID 17237373

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BALB/c, but not the C57, isoform of Ly49B displays promiscuous MHC class I binding.
    Title: Mutagenesis of Ly49B reveals key structural elements required for promiscuous binding to MHC class I molecules and new insights into the molecular evolution of Ly49s.
  2. Ly49B is expressed at low levels on approximately 1.5% of spleen cells, none which are NK cells or T cells but which instead belong to several distinct subpopulations of myeloid cells.
    Title: Ly49B is expressed on multiple subpopulations of myeloid cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
killer cell lectin-like receptor 2
Names
NK cell inhibitory receptor Klra2
T-cell surface glycoprotein Ly-49B
T-cell surface glycoprotein Ly49b
killer cell lectin-like receptor subfamily A member 30
ly-49b
lymphocyte antigen 49b
membrane protein Ly49b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170851.2 → NP_001164322.1  killer cell lectin-like receptor 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC148326, AC163356
    Consensus CDS
    CCDS51929.1
    UniProtKB/TrEMBL
    A0FK58, E9Q433
    Related
    ENSMUSP00000086252.7, ENSMUST00000088867.7
    Conserved Domains (2) summary
    cd03593
    Location:146 → 294
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:40 → 159
    Ly49; Ly49-like protein, N-terminal region

  2. NM_008462.6 → NP_032488.4  killer cell lectin-like receptor 2 isoform 2

    See identical proteins and their annotated locations for NP_032488.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC148326, AC163356
    Consensus CDS
    CCDS20603.1
    UniProtKB/TrEMBL
    Q6P263, Q9D3R1, Q9JHG5
    Related
    ENSMUSP00000032306.9, ENSMUST00000032306.15
    Conserved Domains (2) summary
    cd03593
    Location:146 → 261
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:40 → 159
    Ly49; Ly49-like protein, N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    131196190..131224679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165887.1 → XP_036021780.1  killer cell lectin-like receptor 2 isoform X4

    Conserved Domains (2) summary
    cd03593
    Location:55 → 203
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:1 → 68
    Ly49; Ly49-like protein, N-terminal region

  2. XM_017321416.2 → XP_017176905.1  killer cell lectin-like receptor 2 isoform X1

    Conserved Domains (2) summary
    cd03593
    Location:253 → 401
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:147 → 266
    Ly49; Ly49-like protein, N-terminal region

  3. XM_017321414.2 → XP_017176903.1  killer cell lectin-like receptor 2 isoform X2

    Conserved Domains (2) summary
    cd03593
    Location:253 → 368
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam08391
    Location:147 → 266
    Ly49; Ly49-like protein, N-terminal region

  4. XM_017321415.2 → XP_017176904.1  killer cell lectin-like receptor 2 isoform X3

    Conserved Domains (1) summary
    pfam08391
    Location:147 → 248
    Ly49; Ly49-like protein, N-terminal region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60660.1 GenPept UniProtKB/Swiss-Prot:Q60660

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