Klra1 killer cell lectin-like receptor, subfamily A, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klra1provided by MGI
Official Full Name: killer cell lectin-like receptor, subfamily A, member 1provided by MGI
Primary source: MGI:MGI:101907
See related: Ensembl:ENSMUSG00000079853 AllianceGenome:MGI:101907
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A1; Ly49a; Ly49v; Klra22; Ly49o<129>; CH29-493D4.3
Summary: Enables signaling receptor activity. Predicted to act upstream of or within cell adhesion. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6 F3; 6 63.44 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (130340881..130363837, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (130363918..130386874, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Most of the natural killer cell p46-related protein (NKp46) and NK cell Lectin-like receptor subfamily A (Ly49A) molecules were restricted to microdomains; however, individual NKp46 molecules resided in these domains for shorter periods and diffused faster on the surface of educated, compared to hyporesponsive, NK cells.
Title: Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A.
study found the receptor Ly49A bound the MHC class I molecule H2-M3 with an affinity similar to its affinity for H-2D(d); specific recognition of H2-M3 by Ly49A regulated 'licensing' of NK cells and mediated 'missing-self' recognition of H2-M3-deficient bone marrow
Title: Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells.
The difference in frequency of Ly49A-specific natural killer (NK) cells between H2-Dd+/+ and H2-Dd+/2 mice is reflected by a skewed balance between proliferation and apoptosis in this subset.
Title: Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets.
Overexpression of Ly49A enhanced the tumor killing activity of mouse lymphocytes.
Title: [In vitro study of the killing activities on H-2(d) murine normal and tumor cells by Ly49A gene transfected lymphocytes].
The membrane proximal nonligand binding ecto-domain (the stalk region) of Ly49A is critical to ligand binding and signaling.
Title: Essential role of the Ly49A stalk region for immunological synapse formation and signaling.
Ly49A blocks Zap70, extracellular signal-regulated kinase 1/2 and c-Jun activation but leaves unique components of the CD28 signaling pathway intact.
Title: Engagement of transgenic Ly49A inhibits mouse CD4 cell activation by disrupting T cell receptor, but not CD28, signaling.
The association with MHC-I in cis sequestered wild-type Ly49A, and this was found to relieve NK cells from a suppressive effect of unengaged Ly49A
Title: A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education.
DNA methylation and the histone acetylation state of the Pro-2 promoter region of Ly49a are strictly linked with Ly49a expression status.
Title: Evidence for epigenetic maintenance of Ly49a monoallelic gene expression.
the NK cells' own MHC-I significantly masks the Ly49A and Ly49C, but not the Ly49I receptor
Title: Interactions of Ly49 family receptors with MHC class I ligands in trans and cis.
H-2Dd cis ligand has a role in Ly49A localization to the site of NK cell/target cell contact
Title: Stable masking by H-2Dd cis ligand limits Ly49A relocalization to the site of NK cell/target cell contact.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1) 1 citation

General gene information

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Markers

Klra1 (e-PCR), detects polymorphism
- UniSTS:143704

Klra1 (e-PCR), detects polymorphism
- UniSTS:143705

Klra1 (e-PCR), detects polymorphism
- UniSTS:143706

Klra1 (e-PCR), detects polymorphism
- UniSTS:143707

Klra1 (e-PCR), detects polymorphism
- UniSTS:143708

Klra7 (e-PCR), detects polymorphism
- UniSTS:143715

Klra7 (e-PCR), detects polymorphism
- UniSTS:143717

D6Dcr25 (e-PCR), detects polymorphism
- UniSTS:507756

NoName (e-PCR)
- UniSTS:491398

G54772 (e-PCR)
- UniSTS:166300

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: T-cell surface glycoprotein YE1/48

Names: class I MHC receptor KLRA22; ly-49a; lymphocyte antigen 49a; natural killer cell receptor Ly49A; novel killer cell lectin-like receptor subfamily A protein; t lymphocyte antigen A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016659.3 → NP_057868.2 T-cell surface glycoprotein YE1/48

See identical proteins and their annotated locations for NP_057868.2

Status: VALIDATED

Source sequence(s)

AC087336, AK080158

Consensus CDS

CCDS20602.1

UniProtKB/TrEMBL

Q8BNV4, Q8MHR8, Q925C6

Related

ENSMUSP00000032288.5, ENSMUST00000032288.6

Conserved Domains (2) summary

cd03593
Location:142 → 255

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:40 → 153

Ly49; Ly49-like protein, N-terminal region