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Klk1 kallikrein 1 [ Mus musculus (house mouse) ]

Gene ID: 16612, updated on 21-Apr-2024

Summary

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Official Symbol
Klk1provided by MGI
Official Full Name
kallikrein 1provided by MGI
Primary source
MGI:MGI:102850
See related
Ensembl:ENSMUSG00000063903 AllianceGenome:MGI:102850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kal; Klk6; KAL-B; mGk-6; Klk1b6; 0610007D04Rik
Summary
This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein are unable to generate significant levels of kinins in most tissues, develop cardiovascular abnormalities and exhibit hypercalciuria of renal origin. This gene is located in a cluster of several related kallikrein genes on chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, Feb 2016]
Expression
Biased expression in kidney adult (RPKM 1758.5), colon adult (RPKM 1588.3) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 28.74 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43874784..43879046)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44225360..44229622)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene kallikrein 1-related peptidase b5 Neighboring gene predicted gene 10109 Neighboring gene STARR-seq mESC enhancer starr_18789 Neighboring gene RIKEN cDNA 1700028J19 gene Neighboring gene predicted gene, 36864 Neighboring gene RIKEN cDNA 2410002F23 gene Neighboring gene STARR-positive B cell enhancer ABC_E1085 Neighboring gene predicted gene, 26247

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Blocking of plasma kallikrein ameliorates stroke by reducing thromboinflammation. Göb E, et al. Ann Neurol, 2015 May. PMID 25628066
  2. Antihypertensive role of tissue kallikrein in hyperaldosteronism in the mouse. Waeckel L, et al. Endocrinology, 2012 Aug. PMID 22669897
  3. Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis. Scarisbrick IA, et al. Brain Pathol, 2012 Sep. PMID 22335454, Free PMC Article
  4. Kallikrein protects against microalbuminuria in experimental type I diabetes. Bodin S, et al. Kidney Int, 2009 Aug. PMID 19516248
  5. The lupus-susceptibility gene kallikrein downmodulates antibody-mediated glomerulonephritis. Li QZ, et al. Genes Immun, 2009 Jul. PMID 19262577, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. tissue kallikrein knockout mice had a significant two-fold increase in albuminuria
    Title: Kallikrein protects against microalbuminuria in experimental type I diabetes.
  2. Tissue kallikrein and kinins do not influence the trophicity of kidneys, the synthesis and secretion of renin, blood pressure increase, and cardiac remodeling due to renin angiotensin system activation.
    Title: Tissue kallikrein deficiency and renovascular hypertension in the mouse.
  3. TK, like several other proteases, can activate ENaC in the kidney and the colon.
    Title: Defective ENaC processing and function in tissue kallikrein-deficient mice.
  4. Protective effects of Tissue kallikrein gene transfer on ischemic diseases.
    Title: Regional and global protective effects of tissue kallikrein gene delivery to the peri-infarct myocardium.
  5. Polypeptides identified based on immunorecognition by autoantibodies in sera from IQI/Jic mice affected with autoimmune disease (>12 weeks of age) were tissue kallikrein (Klk)-1 and -13 and were cross-reactive to the autoantibodies.
    Title: Autoimmunity against a tissue kallikrein in IQI/Jic Mice: a model for Sjogren's syndrome.
  6. The study suggests that kallikrein plays an antihypertensive role in hyperaldosteronism.
    Title: Antihypertensive role of tissue kallikrein in hyperaldosteronism in the mouse.
  7. These data do not support a role for the TK-kinin system, protective or deleterious, in the development of insulin resistance and diabetes.
    Title: Tissue kallikrein deficiency, insulin resistance, and diabetes in mouse and man.
  8. Lower excretion of active renin and prorenin in TK(-/-) compared to TK(+/+) suggest coordinated regulation of the two proteins in their participation to collecting duct function.
    Title: Renin and kallikrein in connecting tubule of mouse.
  9. Plasma kallikrein-deficient mice challenged with transient middle cerebral artery occlusion developed significantly smaller brain infarctions.
    Title: Blocking of plasma kallikrein ameliorates stroke by reducing thromboinflammation.
  10. Local expression of kallikreins within the kidney has the capacity to dampen lupus nephritis, possibly by modulating inflammation and oxidative stress.
    Title: Inducible expression of kallikrein in renal tubular cells protects mice against spontaneous lupus nephritis.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zymogen activation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kallikrein-1
Names
glandular kallikrein K1
kallikrein renal/pancreas/salivary
tissue kallikrein-6
true tissue kallikrein
NP_001307260.1
NP_001307261.1
NP_034769.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320331.1 → NP_001307260.1  kallikrein-1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1. This isoform (2) may undergo proteolytic processing simlar to isoform 1.
    Source sequence(s)
    AC124176, AK002278, AV053449, BY087276
    UniProtKB/Swiss-Prot
    P15947
    Conserved Domains (2) summary
    smart00020
    Location:24 → 209
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:25 → 209
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_001320332.1 → NP_001307261.1  kallikrein-1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC124176, AK002278, AV053449, BY087276
    UniProtKB/TrEMBL
    A0A0U1RPN5
    Related
    ENSMUSP00000146057.2, ENSMUST00000206144.2
    Conserved Domains (2) summary
    smart00020
    Location:15 → 151
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:13 → 154
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. NM_010639.8 → NP_034769.4  kallikrein-1 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_034769.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC124176, AK002278, AV053449, BY087276
    Consensus CDS
    CCDS21202.1
    UniProtKB/Swiss-Prot
    P15947, Q61855
    UniProtKB/TrEMBL
    A0A0B6VSQ6, A0A1R3UCI2
    Related
    ENSMUSP00000074659.4, ENSMUST00000075162.5
    Conserved Domains (1) summary
    smart00020
    Location:24 → 253
    Tryp_SPc; Trypsin-like serine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43874784..43879046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15947.3 GenPept UniProtKB/Swiss-Prot:P15947

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