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Kl klotho [ Mus musculus (house mouse) ]

Gene ID: 16591, updated on 21-Apr-2024

Summary

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Official Symbol
Klprovided by MGI
Official Full Name
klothoprovided by MGI
Primary source
MGI:MGI:1101771
See related
Ensembl:ENSMUSG00000058488 AllianceGenome:MGI:1101771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
alpha-kl
Summary
Enables fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Acts upstream of or within several processes, including calcium ion homeostasis; energy reserve metabolic process; and positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be integral component of membrane. Is expressed in brain. Used to study hyperphosphatemic familial tumoral calcinosis and pulmonary emphysema. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward kidney adult (RPKM 58.5) See more
Orthologs
human all
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Genomic context

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Location:
5 89.77 cM; 5 G3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (150876072..150917282)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (150952607..150993817)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene PDS5 cohesin associated factor B Neighboring gene predicted gene, 26013 Neighboring gene STARR-seq mESC enhancer starr_14960 Neighboring gene predicted gene, 36447 Neighboring gene STARR-seq mESC enhancer starr_14962 Neighboring gene STARR-seq mESC enhancer starr_14963 Neighboring gene predicted gene 8675 Neighboring gene StAR related lipid transfer domain containing 13 Neighboring gene STARR-seq mESC enhancer starr_14970 Neighboring gene STARR-seq mESC enhancer starr_14971 Neighboring gene predicted gene, 52834

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium. Jang HY, et al. Cell Death Dis, 2023 May 20. PMID 37210384, Free PMC Article
  2. Klotho alleviates contrast-induced acute kidney injury by suppressing oxidative stress, inflammation, and NF-KappaB/NLRP3-mediated pyroptosis. Fu Y, et al. Int Immunopharmacol, 2023 May. PMID 37018977
  3. mTORC1-Induced Bone Marrow-Derived Mesenchymal Stem Cell Exhaustion Contributes to the Bone Abnormalities in Klotho-Deficient Mice of Premature Aging. Feng R, et al. Stem Cells Dev, 2023 Jun. PMID 36924305
  4. Soluble Klotho protects against glomerular injury through regulation of ER stress response. Charrin E, et al. Commun Biol, 2023 Feb 22. PMID 36813870, Free PMC Article
  5. Klotho promotes AMPK activity and maintains renal vascular integrity by regulating the YAP signaling pathway. Luo L, et al. Int J Med Sci, 2023. PMID 36794161, Free PMC Article

See all (407) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Relationship of the bone phenotype of the Klotho mutant mouse model of accelerated aging to changes in skeletal architecture that occur with chronological aging.
    Title: Relationship of the bone phenotype of the Klotho mutant mouse model of accelerated aging to changes in skeletal architecture that occur with chronological aging.
  2. Histone deacetylase 9 exacerbates podocyte injury in hyperhomocysteinemia through epigenetic repression of Klotho.
    Title: Histone deacetylase 9 exacerbates podocyte injury in hyperhomocysteinemia through epigenetic repression of Klotho.
  3. Klotho regulates the myogenic response of muscle to mechanical loading and exercise.
    Title: Klotho regulates the myogenic response of muscle to mechanical loading and exercise.
  4. Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease.
    Title: Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease.
  5. Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice.
    Title: Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice.
  6. Klotho increases antioxidant defenses in astrocytes and ubiquitin-proteasome activity in neurons.
    Title: Klotho increases antioxidant defenses in astrocytes and ubiquitin-proteasome activity in neurons.
  7. Klotho Null Mutation Involvement in Adenosine A2B Receptor-Related Skeletal Muscle Degeneration.
    Title: Klotho Null Mutation Involvement in Adenosine A2B Receptor-Related Skeletal Muscle Degeneration.
  8. mTORC1-Induced Bone Marrow-Derived Mesenchymal Stem Cell Exhaustion Contributes to the Bone Abnormalities in Klotho-Deficient Mice of Premature Aging.
    Title: mTORC1-Induced Bone Marrow-Derived Mesenchymal Stem Cell Exhaustion Contributes to the Bone Abnormalities in Klotho-Deficient Mice of Premature Aging.
  9. Klotho prevents transforming growth factor-beta2-induced senescent-like morphological changes in the retinal pigment epithelium.
    Title: Klotho prevents transforming growth factor-β2-induced senescent-like morphological changes in the retinal pigment epithelium.
  10. Klotho protects chromosomal DNA from radiation-induced damage.
    Title: Klotho protects chromosomal DNA from radiation-induced damage.
Submit: New GeneRIF Correction See all GeneRIFs (273)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-glucuronidase activity IEA
Inferred from Electronic Annotation
more info
  
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
  
enables fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within energy reserve metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
  
involved_in norepinephrine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
klotho
Names
secreted form of Klotho protein
NP_038851.2
XP_006504980.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013823.2 → NP_038851.2  klotho precursor

    See identical proteins and their annotated locations for NP_038851.2

    Status: VALIDATED

    Source sequence(s)
    AB005141, BC138259
    Consensus CDS
    CCDS19889.1
    UniProtKB/Swiss-Prot
    B2RR78, O35082, O70175, O70621
    Related
    ENSMUSP00000077899.7, ENSMUST00000078856.8
    Conserved Domains (1) summary
    cl23725
    Location:59 → 508
    Glyco_hydro_1; Glycosyl hydrolase family 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    150876072..150917282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504917.1 → XP_006504980.1  klotho isoform X1

    See identical proteins and their annotated locations for XP_006504980.1

    Conserved Domains (1) summary
    cl23725
    Location:61 → 507
    Glyco_hydro; Glycosyl hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35082.2 GenPept UniProtKB/Swiss-Prot:O35082

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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