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Uhmk1 U2AF homology motif (UHM) kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 16589, updated on 21-Apr-2024

Summary

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Official Symbol
Uhmk1provided by MGI
Official Full Name
U2AF homology motif (UHM) kinase 1provided by MGI
Primary source
MGI:MGI:1341908
See related
Ensembl:ENSMUSG00000026667 AllianceGenome:MGI:1341908
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KIS; Kist; P-CIP2; 4732477C12Rik; 4930500M09Rik; C820018A03Rik
Summary
Enables ribonucleoprotein complex binding activity. Involved in neuron projection development and positive regulation of translational initiation. Located in axon; dendrite cytoplasm; and neuronal ribonucleoprotein granule. Is expressed in brain; heart; liver; metanephros; and musculature. Orthologous to human UHMK1 (U2AF homology motif kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 12.7), ovary adult (RPKM 8.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H3; 1 76.84 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170020989..170043466, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170193422..170215897, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110045C21 gene Neighboring gene discoidin domain receptor family, member 2 Neighboring gene STARR-seq mESC enhancer starr_02981 Neighboring gene STARR-seq mESC enhancer starr_02982 Neighboring gene STARR-seq mESC enhancer starr_02983 Neighboring gene STARR-seq mESC enhancer starr_02984 Neighboring gene STARR-seq mESC enhancer starr_02986 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4380 Neighboring gene STARR-seq mESC enhancer starr_02987 Neighboring gene STARR-positive B cell enhancer ABC_E3325 Neighboring gene STARR-seq mESC enhancer starr_02988 Neighboring gene STARR-seq mESC enhancer starr_02989 Neighboring gene STARR-positive B cell enhancer mm9_chr1:172185797-172186097 Neighboring gene SH2 domain containing 1B2 Neighboring gene predicted gene 6345

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KIS, a kinase associated with microtubule regulators, enhances translation of AMPA receptors and stimulates dendritic spine remodeling. Pedraza N, et al. J Neurosci, 2014 Oct 15. PMID 25319695, Free PMC Article
  2. UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism. Feng X, et al. EMBO J, 2020 Mar 2. PMID 31975428, Free PMC Article
  3. Different requirements of the kinase and UHM domains of KIS for its nuclear localization and binding to splicing factors. Manceau V, et al. J Mol Biol, 2008 Sep 5. PMID 18588901, Free PMC Article
  4. Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human. Bièche I, et al. Brain Res Mol Brain Res, 2003 May 26. PMID 12782393
  5. KIS is a protein kinase with an RNA recognition motif. Maucuer A, et al. J Biol Chem, 1997 Sep 12. PMID 9287318

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism.
    Title: UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism.
  2. The absence of KIS results in a significant decrease in AMPA receptors in dendritic spines.
    Title: KIS, a kinase associated with microtubule regulators, enhances translation of AMPA receptors and stimulates dendritic spine remodeling.
  3. disregulation of gene expression due to KIS inactivation affects specific brain functions.
    Title: The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice.
  4. Uhmk1 was concentrated in the nucleus, but cycled rapidly between nucleus and cytosol.
    Title: Signaling from the secretory granule to the nucleus: Uhmk1 and PAM.
  5. KIS is a component of the molecular device that modulates translation in RNA-transporting granules as a result of local signals.
    Title: Protein kinase KIS localizes to RNA granules and enhances local translation.
  6. Phosphorylation of p27Kip1 by KIS leads to cell-cycle progression, whereas the target sequence and the physiological relevance of KIS-mediated stathmin phosphorylation in VSMCs
    Title: KIS protects against adverse vascular remodeling by opposing stathmin-mediated VSMC migration in mice.
  7. Endogenous mouse KIS was detected mainly in the nucleus of asynchronously growing cells. During serum starvation, its expression was reduced.
    Title: A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables splicing factor binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuronal ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Kist
Names
PAM COOH-terminal interactor protein 2
U2AF homology motif kinase 1
kinase interacting with leukemia-associated gene (stathmin)
kinase interacting with stathmin
NP_001347738.1
NP_034763.3
XP_006496745.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360809.1 → NP_001347738.1  serine/threonine-protein kinase Kist isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC123650, AK030152
    Consensus CDS
    CCDS87917.1
    UniProtKB/TrEMBL
    Q8C0N6
    Related
    ENSMUSP00000115622.2, ENSMUST00000150821.8
    Conserved Domains (2) summary
    cd12465
    Location:229 → 316
    RRM_UHMK1; RNA recognition motif found in U2AF homology motif kinase 1 (UHMK1) and similar proteins
    cl21453
    Location:1 → 219
    PKc_like; Protein Kinases, catalytic domain

  2. NM_010633.4 → NP_034763.3  serine/threonine-protein kinase Kist isoform 1

    See identical proteins and their annotated locations for NP_034763.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC123650, BC058732
    Consensus CDS
    CCDS15468.1
    UniProtKB/Swiss-Prot
    P97343, Q61775, Q9CYT1
    Related
    ENSMUSP00000027979.8, ENSMUST00000027979.14
    Conserved Domains (2) summary
    cd12465
    Location:318 → 405
    RRM_UHMK1; RNA recognition motif found in U2AF homology motif kinase 1 (UHMK1) and similar proteins
    cd14020
    Location:22 → 308
    STKc_KIS; Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    170020989..170043466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496682.4 → XP_006496745.1  serine/threonine-protein kinase Kist isoform X1

    UniProtKB/TrEMBL
    D3YUF5
    Related
    ENSMUSP00000120787.2, ENSMUST00000123399.2
    Conserved Domains (2) summary
    cd14020
    Location:22 → 308
    STKc_KIS; Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1)
    cl17169
    Location:318 → 341
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_004940648.1 RNA Sequence

  2. XR_004940646.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97343.3 GenPept UniProtKB/Swiss-Prot:P97343

Gene LinkOut

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