U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GPR156 G protein-coupled receptor 156 [ Homo sapiens (human) ]

Gene ID: 165829, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
GPR156provided by HGNC
Official Full Name
G protein-coupled receptor 156provided by HGNC
Primary source
HGNC:HGNC:20844
See related
Ensembl:ENSG00000175697 MIM:610464; AllianceGenome:HGNC:20844
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR28; GABABL; DFNB121
Summary
G protein-coupled receptors (GPCRs) are a large superfamily of cell surface receptors characterized by 7 helical transmembrane domains, together with N-terminal extracellular and C-terminal intracellular domains.[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 1.8), ovary (RPKM 0.3) and 7 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3q13.33
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (120165478..120285222, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (122885139..123004744, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (119884325..120004069, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 762, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 397, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:119863928-119865127 Neighboring gene uncharacterized LOC105374065 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:119889176-119889400 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:119961559-119962758 Neighboring gene uncharacterized LOC124909418 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:120032196-120032799 Neighboring gene PTOV1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14635 Neighboring gene leucine rich repeat containing 58

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor. Calver AR, et al. Brain Res Mol Brain Res, 2003 Feb 20. PMID 12591167
  2. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. Fu GK, et al. Genomics, 2004 Jul. PMID 15203218
  3. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014
  5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel GPR156 variants confirm its role in moderate sensorineural hearing loss.
    Title: Novel GPR156 variants confirm its role in moderate sensorineural hearing loss.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Deafness, autosomal recessive 121
MedGen: CN375630 OMIM: 620551 GeneReviews: Not available
Compare labs

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC142261

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled GABA receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of G protein-coupled receptor heterodimeric complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

Go to the top of the page Help
Preferred Names
probable G-protein coupled receptor 156
Names
G protein-coupled receptor PGR28
GABAB-related G-protein coupled receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168271.2 → NP_001161743.1  probable G-protein coupled receptor 156 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC063952, AC092897, AI201720, BC143606, BX115336, CD638213
    Consensus CDS
    CCDS54629.1
    UniProtKB/Swiss-Prot
    Q8NFN8
    Related
    ENSP00000418758.1, ENST00000461057.1
    Conserved Domains (1) summary
    pfam00003
    Location:71 → 308
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

  2. NM_153002.3 → NP_694547.2  probable G-protein coupled receptor 156 isoform 1

    See identical proteins and their annotated locations for NP_694547.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC063952, AC092897, AF488739, AI201720, BX115336, CD638213
    Consensus CDS
    CCDS2997.1
    UniProtKB/Swiss-Prot
    B7ZL66, E9PFZ4, Q14CM1, Q86SN6, Q8NFN8
    Related
    ENSP00000417261.1, ENST00000464295.6
    Conserved Domains (1) summary
    pfam00003
    Location:71 → 312
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    120165478..120285222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005796.2 → XP_016861285.1  probable G-protein coupled receptor 156 isoform X1

    UniProtKB/Swiss-Prot
    B7ZL66, E9PFZ4, Q14CM1, Q86SN6, Q8NFN8
    Conserved Domains (1) summary
    pfam00003
    Location:71 → 312
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

  2. XM_017005795.2 → XP_016861284.1  probable G-protein coupled receptor 156 isoform X1

    UniProtKB/Swiss-Prot
    B7ZL66, E9PFZ4, Q14CM1, Q86SN6, Q8NFN8
    Conserved Domains (1) summary
    pfam00003
    Location:71 → 312
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

  3. XM_011512487.2 → XP_011510789.1  probable G-protein coupled receptor 156 isoform X2

    See identical proteins and their annotated locations for XP_011510789.1

    Conserved Domains (1) summary
    pfam00003
    Location:1 → 231
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

  4. XM_047447586.1 → XP_047303542.1  probable G-protein coupled receptor 156 isoform X2

  5. XM_011512488.3 → XP_011510790.1  probable G-protein coupled receptor 156 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    122885139..123004744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345481.1 → XP_054201456.1  probable G-protein coupled receptor 156 isoform X1

  2. XM_054345482.1 → XP_054201457.1  probable G-protein coupled receptor 156 isoform X1

  3. XM_054345483.1 → XP_054201458.1  probable G-protein coupled receptor 156 isoform X2

  4. XM_054345484.1 → XP_054201459.1  probable G-protein coupled receptor 156 isoform X2

  5. XM_054345485.1 → XP_054201460.1  probable G-protein coupled receptor 156 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NFN8.2 GenPept UniProtKB/Swiss-Prot:Q8NFN8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous