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Kifc2 kinesin family member C2 [ Mus musculus (house mouse) ]

Gene ID: 16581, updated on 30-Apr-2024

Summary

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Official Symbol
Kifc2provided by MGI
Official Full Name
kinesin family member C2provided by MGI
Primary source
MGI:MGI:109187
See related
Ensembl:ENSMUSG00000004187 AllianceGenome:MGI:109187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement and mitotic spindle assembly. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of kinesin complex. Predicted to be active in microtubule cytoskeleton and nucleus. Is expressed in several structures, including 4-cell stage embryo; alimentary system; genitourinary system; nervous system; and sensory organ. Orthologous to human KIFC2 (kinesin family member C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 113.0), frontal lobe adult (RPKM 87.4) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D3; 15 36.23 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76543984..76552396)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76659784..76668196)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene tonsoku-like, DNA repair protein Neighboring gene STARR-positive B cell enhancer ABC_E1481 Neighboring gene zinc finger TRAF type containing 1 Neighboring gene predicted gene, 57852 Neighboring gene STARR-positive B cell enhancer ABC_E760 Neighboring gene STARR-positive B cell enhancer ABC_E9419 Neighboring gene STARR-positive B cell enhancer ABC_E3145 Neighboring gene transmembrane protein 276 Neighboring gene STARR-positive B cell enhancer ABC_E5491 Neighboring gene forkhead box H1 Neighboring gene STARR-seq mESC enhancer starr_39060 Neighboring gene protein phosphatase 1, regulatory subunit 16A Neighboring gene glutamic pyruvic transaminase, soluble

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of mouse C-terminal kinesin motor KifC2. Yang Z, et al. Mol Cell Biol, 2001 Apr. PMID 11259594, Free PMC Article
  2. Characterization of KIFC2, a neuronal kinesin superfamily member in mouse. Hanlon DW, et al. Neuron, 1997 Mar. PMID 9115737
  3. KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles. Saito N, et al. Neuron, 1997 Mar. PMID 9115736
  4. Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver. Nath S, et al. Mol Biol Cell, 2007 May. PMID 17360972, Free PMC Article
  5. T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis. Venables JP, et al. Hum Mol Genet, 1999 Jun. PMID 10332027

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
NOT located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kinesin-like protein KIFC2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358909.2 → NP_001345838.1  kinesin-like protein KIFC2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC156550
    Consensus CDS
    CCDS88791.1
    UniProtKB/TrEMBL
    A0A2R8W6X1, Q3UNC4
    Related
    ENSMUSP00000155536.2, ENSMUST00000230451.2
    Conserved Domains (2) summary
    COG1196
    Location:145 → 266
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:322 → 649
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  2. NM_001358910.2 → NP_001345839.1  kinesin-like protein KIFC2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC156550
    Consensus CDS
    CCDS88791.1
    UniProtKB/TrEMBL
    A0A2R8W6X1, Q3UNC4
    Conserved Domains (2) summary
    COG1196
    Location:145 → 266
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:322 → 649
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  3. NM_001358911.2 → NP_001345840.1  kinesin-like protein KIFC2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC156550
    UniProtKB/Swiss-Prot
    O08613, O08672
    Conserved Domains (2) summary
    cd01366
    Location:390 → 717
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:224 → 336
    SMC_N; RecF/RecN/SMC N terminal domain

  4. NM_001358912.2 → NP_001345841.1  kinesin-like protein KIFC2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC156550
    UniProtKB/Swiss-Prot
    O08613, O08672
    Conserved Domains (2) summary
    cd01366
    Location:387 → 714
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    cl25732
    Location:237 → 325
    SMC_N; RecF/RecN/SMC N terminal domain

  5. NM_001416290.1 → NP_001403219.1  kinesin-like protein KIFC2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC156550
    UniProtKB/TrEMBL
    A0A2R8W6X1

  6. NM_001416296.1 → NP_001403225.1  kinesin-like protein KIFC2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC156550

  7. NM_001416297.1 → NP_001403226.1  kinesin-like protein KIFC2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC156550

  8. NM_001416298.1 → NP_001403227.1  kinesin-like protein KIFC2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC156550

  9. NM_001416299.1 → NP_001403228.1  kinesin-like protein KIFC2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC156550

  10. NM_001416300.1 → NP_001403229.1  kinesin-like protein KIFC2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC156550

  11. NM_001416301.1 → NP_001403230.1  kinesin-like protein KIFC2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC156550

  12. NM_001416302.1 → NP_001403231.1  kinesin-like protein KIFC2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC156550

  13. NM_001416303.1 → NP_001403232.1  kinesin-like protein KIFC2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC156550

  14. NM_001416304.1 → NP_001403233.1  kinesin-like protein KIFC2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC156550

  15. NM_001416305.1 → NP_001403234.1  kinesin-like protein KIFC2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC156550

  16. NM_001416306.1 → NP_001403235.1  kinesin-like protein KIFC2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC156550

  17. NM_001416307.1 → NP_001403236.1  kinesin-like protein KIFC2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC156550

  18. NM_001416308.1 → NP_001403237.1  kinesin-like protein KIFC2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC156550

  19. NM_010630.4 → NP_034760.2  kinesin-like protein KIFC2 isoform 1

    See identical proteins and their annotated locations for NP_034760.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC156550
    Consensus CDS
    CCDS27583.1
    UniProtKB/Swiss-Prot
    O08613, O08672
    UniProtKB/TrEMBL
    G3X8Q6
    Related
    ENSMUSP00000004294.11, ENSMUST00000004294.12
    Conserved Domains (2) summary
    smart00129
    Location:409 → 735
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01366
    Location:407 → 734
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

RNA

  1. NR_183664.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156550

  2. NR_183665.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156550
    Related
    ENSMUST00000230964.2

  3. NR_183666.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156550

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76543984..76552396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248350.2 → XP_030104210.1  kinesin-like protein KIFC2 isoform X3

    Conserved Domains (1) summary
    cd01366
    Location:68 → 395
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  2. XM_030248356.1 → XP_030104216.1  kinesin-like protein KIFC2 isoform X3

    Conserved Domains (1) summary
    cd01366
    Location:68 → 395
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  3. XM_030248351.1 → XP_030104211.1  kinesin-like protein KIFC2 isoform X3

    Conserved Domains (1) summary
    cd01366
    Location:68 → 395
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  4. XM_030248349.1 → XP_030104209.1  kinesin-like protein KIFC2 isoform X3

    Conserved Domains (1) summary
    cd01366
    Location:68 → 395
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  5. XM_030248346.2 → XP_030104206.1  kinesin-like protein KIFC2 isoform X1

    UniProtKB/TrEMBL
    A0A2R8W6X1, Q3UNC4
    Related
    ENSMUST00000230124.2
    Conserved Domains (2) summary
    COG1196
    Location:145 → 266
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01366
    Location:322 → 649
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  6. XM_036159191.1 → XP_036015084.1  kinesin-like protein KIFC2 isoform X2

    UniProtKB/TrEMBL
    Q3UNC4
    Conserved Domains (1) summary
    cd01366
    Location:305 → 632
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  7. XM_036159193.1 → XP_036015086.1  kinesin-like protein KIFC2 isoform X3

    Conserved Domains (1) summary
    cd01366
    Location:68 → 395
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

RNA

  1. XR_383988.3 RNA Sequence

  2. XR_001781497.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08672.1 GenPept UniProtKB/Swiss-Prot:O08672

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