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Kif11 kinesin family member 11 [ Mus musculus (house mouse) ]

Gene ID: 16551, updated on 21-Apr-2024

Summary

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Official Symbol
Kif11provided by MGI
Official Full Name
kinesin family member 11provided by MGI
Primary source
MGI:MGI:1098231
See related
Ensembl:ENSMUSG00000012443 AllianceGenome:MGI:1098231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eg5; Kif8; Kifl1; Knsl1
Summary
Predicted to enable plus-end-directed microtubule motor activity and protein kinase binding activity. Acts upstream of or within mitotic centrosome separation and spindle assembly. Predicted to be located in cytosol; microtubule; and mitotic spindle. Predicted to be part of protein-containing complex. Predicted to be active in nucleus and spindle microtubule. Predicted to colocalize with spindle pole. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Orthologous to human KIF11 (kinesin family member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 30.5), liver E14 (RPKM 27.0) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C2; 19 32.27 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (37364830..37410311)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (37376382..37421863)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931408D14 gene Neighboring gene STARR-positive B cell enhancer ABC_E8748 Neighboring gene insulin degrading enzyme Neighboring gene ribosomal protein L10, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_46050 Neighboring gene STARR-positive B cell enhancer ABC_E7648 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:37444922-37445105 Neighboring gene STARR-seq mESC enhancer starr_46052 Neighboring gene STARR-positive B cell enhancer ABC_E7649 Neighboring gene STARR-positive B cell enhancer ABC_E11674 Neighboring gene STARR-seq mESC enhancer starr_46054 Neighboring gene mortality factor 4 like 1 pseudogene Neighboring gene predicted gene, 46649 Neighboring gene hematopoietically expressed homeobox Neighboring gene RIKEN cDNA 1700122C19 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In Vitro Maturation of Mouse Oocytes Increases the Level of Kif11/Eg5 on Meiosis II Spindles. Kovacovicova K, et al. Biol Reprod, 2016 Jul. PMID 27146033
  2. Delivery of kinesin spindle protein targeting siRNA in solid lipid nanoparticles to cellular models of tumor vasculature. Ying B, et al. Biochem Biophys Res Commun, 2014 Apr 4. PMID 24607899
  3. Photocontrol of the mitotic kinesin Eg5 using a novel S-trityl-L-cysteine analogue as a photochromic inhibitor. Ishikawa K, et al. J Biochem, 2014 Apr. PMID 24451491
  4. Photocontrol of mitotic kinesin Eg5 facilitated by thiol-reactive photochromic molecules incorporated into the loop L5 functional loop. Ishikawa K, et al. J Biochem, 2014 Mar. PMID 24334276
  5. Disruption of the mitotic kinesin Eg5 gene (Knsl1) results in early embryonic lethality. Chauvière M, et al. Biochem Biophys Res Commun, 2008 Aug 8. PMID 18474226

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of KIF11 ameliorates osteoclastogenesis via regulating mTORC1-mediated NF-kappaB signaling.
    Title: Inhibition of KIF11 ameliorates osteoclastogenesis via regulating mTORC1-mediated NF-κB signaling.
  2. LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A.
    Title: LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A.
  3. ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11.
    Title: ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11.
  4. A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy.
    Title: A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy.
  5. TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability.
    Title: TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability.
  6. KIF11 (kinesin-5/Eg5), which functions in spindle formation during mitosis and meiosis in oocytes and early embryos, is expressed in premeiotic germ cells (spermatogonia and spermatocytes).
    Title: KIF11 as a Potential Marker of Spermatogenesis Within Mouse Seminiferous Tubule Cross-sections.
  7. Kif11 regulates excitatory synaptic transmission. Kif11 knockdown enhanced dendritic arborization, synapse number, expression of synaptophysin and Piccolo in vitro.
    Title: Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms.
  8. NEK7 regulates dendrite morphogenesis in vitro and in vivo. NEK7 kinase activity is required for dendrite growth and branching, as well as spine formation and morphology. NEK7 regulates these processes in part through phosphorylation of the kinesin Eg5/KIF11, promoting its accumulation on microtubules in distal dendrites.
    Title: NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization.
  9. that Pten, through the Dlg1-binding ability of its PDZ-binding domain , accumulates phosphorylated Eg5 at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes
    Title: Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes.
  10. Fbxo30-Eg5 interaction as a critical checkpoint in mammopoiesis.
    Title: Fbxo30 Regulates Mammopoiesis by Targeting the Bipolar Mitotic Kinesin Eg5.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic centrosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic centrosome separation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with spindle microtubule ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF11
Names
kinesin-like 1
kinesin-related motor protein Eg5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010615.2 → NP_034745.1  kinesin-like protein KIF11

    See identical proteins and their annotated locations for NP_034745.1

    Status: VALIDATED

    Source sequence(s)
    BC060670, BY097786, CJ206639
    Consensus CDS
    CCDS29777.1
    UniProtKB/Swiss-Prot
    Q6P9P6, Q9Z1J0
    Related
    ENSMUSP00000012587.4, ENSMUST00000012587.4
    Conserved Domains (3) summary
    smart00129
    Location:17 → 365
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01364
    Location:15 → 367
    KISc_BimC_Eg5; Kinesin motor domain, BimC/Eg5 spindle pole proteins
    pfam13931
    Location:915 → 1047
    Microtub_bind; Kinesin-associated microtubule-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    37364830..37410311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P9P6.1 GenPept UniProtKB/Swiss-Prot:Q6P9P6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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