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Kcns1 K+ voltage-gated channel, subfamily S, 1 [ Mus musculus (house mouse) ]

Gene ID: 16538, updated on 11-Apr-2024

Summary

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Official Symbol
Kcns1provided by MGI
Official Full Name
K+ voltage-gated channel, subfamily S, 1provided by MGI
Primary source
MGI:MGI:1197019
See related
Ensembl:ENSMUSG00000040164 AllianceGenome:MGI:1197019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kv9.1
Summary
Predicted to enable delayed rectifier potassium channel activity and potassium channel regulator activity. Involved in potassium ion transport and regulation of delayed rectifier potassium channel activity. Located in perinuclear region of cytoplasm and plasma membrane. Part of voltage-gated potassium channel complex. Orthologous to human KCNS1 (potassium voltage-gated channel modifier subfamily S member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 4.4), limb E14.5 (RPKM 3.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Kcns1 in Genome Data Viewer
Location:
2 H3; 2 84.6 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164005539..164013865, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164163619..164171113, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 34 Neighboring gene STARR-positive B cell enhancer ABC_E10160 Neighboring gene STARR-positive B cell enhancer ABC_E6014 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:163910112-163910326 Neighboring gene serine/threonine kinase 4 Neighboring gene STARR-positive B cell enhancer mm9_chr2:163954265-163954566 Neighboring gene RIKEN cDNA A730032A03 gene Neighboring gene predicted gene, 53202 Neighboring gene WAP four-disulfide core domain 5 Neighboring gene WAP four-disulfide core domain 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice lacking Kcns1 in peripheral neurons show increased basal and neuropathic pain sensitivity. Tsantoulas C, et al. Pain, 2018 Aug. PMID 29697531, Free PMC Article
  2. New modulatory alpha subunits for mammalian Shab K+ channels. Salinas M, et al. J Biol Chem, 1997 Sep 26. PMID 9305895
  3. Ion channel expression in the developing enteric nervous system. Hirst CS, et al. PLoS One, 2015. PMID 25798587, Free PMC Article
  4. Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Harrell MD, et al. Physiol Genomics, 2007 Feb 12. PMID 16985003
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of delayed rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily S member 1
Names
delayed-rectifier K(+) channel alpha subunit 1
voltage-gated potassium channel subunit Kv9.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008435.2 → NP_032461.2  potassium voltage-gated channel subfamily S member 1

    See identical proteins and their annotated locations for NP_032461.2

    Status: VALIDATED

    Source sequence(s)
    AF008573, AK158889, AL591512, AW047812, BY127291
    Consensus CDS
    CCDS17022.1
    UniProtKB/Swiss-Prot
    A2A5M1, O35173
    UniProtKB/TrEMBL
    Q3TY49
    Related
    ENSMUSP00000038901.4, ENSMUST00000045196.4
    Conserved Domains (2) summary
    cl38908
    Location:21 → 126
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:188 → 439
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164005539..164013865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158792.1 → XP_036014685.1  potassium voltage-gated channel subfamily S member 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A5M1, O35173
    UniProtKB/TrEMBL
    Q3TY49
    Conserved Domains (2) summary
    cl38908
    Location:21 → 126
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:188 → 439
    Ion_trans; Ion transport protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35173.2 GenPept UniProtKB/Swiss-Prot:O35173

Gene LinkOut

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