Kcnk5 potassium channel, subfamily K, member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnk5provided by MGI
Official Full Name: potassium channel, subfamily K, member 5provided by MGI
Primary source: MGI:MGI:1336175
See related: Ensembl:ENSMUSG00000023243 AllianceGenome:MGI:1336175
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KCNK5b; TASK-2
Summary: Enables voltage-gated potassium channel activity. Involved in potassium ion export across plasma membrane. Acts upstream of or within potassium ion import across plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in brain; brain meninges; and heart. Orthologous to human KCNK5 (potassium two pore domain channel subfamily K member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in colon adult (RPKM 20.0), duodenum adult (RPKM 13.4) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 11.43 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (20190125..20231850, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (20140057..20181782, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A role for TASK2 channels in the human immunological synapse.
Title: A role for TASK2 channels in the human immunological synapse.
Structural basis for pH gating of the two-pore domain K(+) channel TASK2.
Title: Structural basis for pH gating of the two-pore domain K(+) channel TASK2.
Results suggest a mechanism for K2P5.1 up-regulation via HIF-1 in the CD4(+) T cells of the mouse model for inflammatory bowel.
Title: Possible Contribution of Inflammation-Associated Hypoxia to Increased K(2P)5.1 K(+) Channel Expression in CD4(+) T cells of the Mouse Model for Inflammatory Bowel Disease.
The apparent affinity of TASK-2 for membrane PI(4,5)P2 is low and it is conceivable that changing competition by intracellular polycationic compounds might mediate the previously reported sensitivity of TASK-2 to changes in cell volume. A decrease in PI(4,5)P2 by activation of Gq-PCRs is also probably responsible for TASK-2 inhibition.
Title: Phosphatidylinositol (4,5)-bisphosphate dynamically regulates the K(2P) background K(+) channel TASK-2.
KCNK5 channels are indispensable for the maintenance of hearing. KCNK5 is mainly found in outer sulcus Claudius', Boettcher's and root cells.
Title: KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing.
The data identify GPR4 and TASK-2 as distinct, parallel, and essential central mediators of respiratory chemosensitivity.
Title: PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons.
TASK-2 is upregulated under hypoxia in a HIF-1alpha-dependent manner in B cells.
Title: HIF-1α-mediated upregulation of TASK-2 K⁺ channels augments Ca²⁺ signaling in mouse B cells under hypoxia.
The strong physiological impairment of KCNK5 in Ehrlich cells after long-term hypotonic stimulation is predominantly due to down-regulation of the KCNK5 protein synthesis.
Title: KCNK5 is functionally down-regulated upon long-term hypotonicity in Ehrlich ascites tumor cells.
data are compatible with the concept that TASK-2 channels are modulated by Gbetagamma subunits of heterotrimeric G protein; propose that this modulation is a novel way in which TASK-2 can be tuned to its physiological functions
Title: G protein modulation of K2P potassium channel TASK-2 : a role of basic residues in the C terminus domain.
alkaline-activated TASK-2 channels contribute to pH sensitivity in retrotrapezoid nucleus neurons
Title: TASK-2 channels contribute to pH sensitivity of retrotrapezoid nucleus chemoreceptor neurons.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (4) 1 citation
Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in potassium ion export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within potassium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of resting membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in stabilization of membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: potassium channel subfamily K member 5

Names: potassium channel, subfamily, member 5 (KCNK5); potassium inwardly-rectifying channel, subfamily K, member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021542.4 → NP_067517.1 potassium channel subfamily K member 5

See identical proteins and their annotated locations for NP_067517.1

Status: PROVISIONAL

Source sequence(s)

AC126275

Consensus CDS

CCDS26841.1

UniProtKB/TrEMBL

Q3T9D4, Q9JK62

Related

ENSMUSP00000024011.9, ENSMUST00000024011.10

Conserved Domains (1) summary

pfam07885
Location:81 → 137

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

20190125..20231850 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518590.4 → XP_006518653.1 potassium channel subfamily K member 5 isoform X1

Conserved Domains (1) summary

pfam07885
Location:4 → 61

Ion_trans_2; Ion channel