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Kcnk2 potassium channel, subfamily K, member 2 [ Mus musculus (house mouse) ]

Gene ID: 16526, updated on 21-Apr-2024

Summary

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Official Symbol
Kcnk2provided by MGI
Official Full Name
potassium channel, subfamily K, member 2provided by MGI
Primary source
MGI:MGI:109366
See related
Ensembl:ENSMUSG00000037624 AllianceGenome:MGI:109366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TREK-1; A430027H14Rik
Summary
Enables voltage-gated potassium channel activity. Acts upstream of or within G protein-coupled receptor signaling pathway; potassium ion transport; and regulation of membrane potential. Located in plasma membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including brain; early conceptus; limb; olfactory epithelium; and secondary oocyte. Orthologous to human KCNK2 (potassium two pore domain channel subfamily K member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 6.7), cortex adult (RPKM 5.7) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H6; 1 94.22 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (188940127..189134951, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (189207930..189402782, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57563 Neighboring gene predicted gene, 53520 Neighboring gene STARR-seq mESC enhancer starr_03392 Neighboring gene VISTA enhancer mm119 Neighboring gene programmed cell death 5, pseudogene Neighboring gene RIKEN cDNA A430027H14 gene Neighboring gene STARR-seq mESC enhancer starr_03395 Neighboring gene STARR-seq mESC enhancer starr_03396 Neighboring gene STARR-seq mESC enhancer starr_03397 Neighboring gene predicted gene, 46177 Neighboring gene STARR-seq mESC enhancer starr_03398 Neighboring gene predicted gene, 30088

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Activation of the TREK-1 Potassium Channel Improved Cognitive Deficits in a Mouse Model of Alzheimer's Disease by Modulating Glutamate Metabolism. Li F, et al. Mol Neurobiol, 2022 Aug. PMID 35678977
  2. The Two-Pore Domain Potassium Channel TREK-1 Promotes Blood-Brain Barrier Breakdown and Exacerbates Neuronal Death After Focal Cerebral Ischemia in Mice. Zheng X, et al. Mol Neurobiol, 2022 Apr. PMID 35067892
  3. K(2P)2.1 (TREK-1) potassium channel activation protects against hyperoxia-induced lung injury. Zyrianova T, et al. Sci Rep, 2020 Dec 15. PMID 33319831, Free PMC Article
  4. Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification. Dionisi M, et al. Int J Mol Sci, 2020 Sep 28. PMID 32998392, Free PMC Article
  5. Genetic and pharmacological inhibition of two-pore domain potassium channel TREK-1 alters depression-related behaviors and neuronal plasticity in the hippocampus in mice. Wu F, et al. CNS Neurosci Ther, 2021 Feb. PMID 32864894, Free PMC Article

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myometrium infection decreases TREK1 through NHE1 and increases contraction in pregnant mice.
    Title: Myometrium infection decreases TREK1 through NHE1 and increases contraction in pregnant mice.
  2. Two-pore potassium channel TREK-1 (K2P2.1) regulates NLRP3 inflammasome activity in macrophages.
    Title: Two-pore potassium channel TREK-1 (K2P2.1) regulates NLRP3 inflammasome activity in macrophages.
  3. Activation of TREK-1 (K2P2.1) potassium channels protects against influenza A-induced lung injury.
    Title: Activation of TREK-1 (K(2P)2.1) potassium channels protects against influenza A-induced lung injury.
  4. beta-COP Regulates TWIK1/TREK1 Heterodimeric Channel-Mediated Passive Conductance in Astrocytes.
    Title: β-COP Regulates TWIK1/TREK1 Heterodimeric Channel-Mediated Passive Conductance in Astrocytes.
  5. Activation of the TREK-1 Potassium Channel Improved Cognitive Deficits in a Mouse Model of Alzheimer's Disease by Modulating Glutamate Metabolism.
    Title: Activation of the TREK-1 Potassium Channel Improved Cognitive Deficits in a Mouse Model of Alzheimer's Disease by Modulating Glutamate Metabolism.
  6. The Two-Pore Domain Potassium Channel TREK-1 Promotes Blood-Brain Barrier Breakdown and Exacerbates Neuronal Death After Focal Cerebral Ischemia in Mice.
    Title: The Two-Pore Domain Potassium Channel TREK-1 Promotes Blood-Brain Barrier Breakdown and Exacerbates Neuronal Death After Focal Cerebral Ischemia in Mice.
  7. Genetic and pharmacological inhibition of two-pore domain potassium channel TREK-1 alters depression-related behaviors and neuronal plasticity in the hippocampus in mice.
    Title: Genetic and pharmacological inhibition of two-pore domain potassium channel TREK-1 alters depression-related behaviors and neuronal plasticity in the hippocampus in mice.
  8. K2P2.1 (TREK-1) potassium channel activation protects against hyperoxia-induced lung injury.
    Title: K(2P)2.1 (TREK-1) potassium channel activation protects against hyperoxia-induced lung injury.
  9. Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification.
    Title: Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification.
  10. TREK-1 Null Impairs Neuronal Excitability, Synaptic Plasticity, and Cognitive Function.
    Title: TREK-1 Null Impairs Neuronal Excitability, Synaptic Plasticity, and Cognitive Function.
Submit: New GeneRIF Correction See all GeneRIFs (71)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (6) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables outward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium ion leak channel activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemical synaptic transmission, postsynaptic IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemical synaptic transmission, postsynaptic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of membrane potential IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within stabilization of membrane potential TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in astrocyte projection ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
located_in calyx of Held ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
potassium channel subfamily K member 2
Names
TREK-1 K(+) channel subunit
outward rectifying potassium channel protein TREK-1
two pore potassium channel TPKC1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159850.2 → NP_001153322.1  potassium channel subfamily K member 2 isoform 1

    See identical proteins and their annotated locations for NP_001153322.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC121882, AC124527
    Consensus CDS
    CCDS48480.1
    UniProtKB/Swiss-Prot
    P97438, Q4VQI2
    Related
    ENSMUSP00000141891.2, ENSMUST00000193319.6
    Conserved Domains (1) summary
    pfam07885
    Location:139 → 196
    Ion_trans_2; Ion channel

  2. NM_001281847.2 → NP_001268776.1  potassium channel subfamily K member 2 isoform 3

    See identical proteins and their annotated locations for NP_001268776.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC121882, AC124527
    Consensus CDS
    CCDS78773.1
    UniProtKB/TrEMBL
    Q6P6P9
    Related
    ENSMUSP00000078416.8, ENSMUST00000079451.13
    Conserved Domains (1) summary
    pfam07885
    Location:127 → 184
    Ion_trans_2; Ion channel

  3. NM_001281848.1 → NP_001268777.1  potassium channel subfamily K member 2 isoform 4

    See identical proteins and their annotated locations for NP_001268777.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK164197, BQ174170
    Conserved Domains (1) summary
    pfam07885
    Location:137 → 215
    Ion_trans_2; Ion channel

  4. NM_001357119.2 → NP_001344048.1  potassium channel subfamily K member 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121882, AC124527
    Conserved Domains (1) summary
    pfam07885
    Location:137 → 215
    Ion_trans_2; Ion channel

  5. NM_001402774.1 → NP_001389703.1  potassium channel subfamily K member 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC121882, AC124527, AC132286
    UniProtKB/TrEMBL
    A0A0A6YXK1
    Related
    ENSMUSP00000142026.2, ENSMUST00000194402.6

  6. NM_001402775.1 → NP_001389704.1  potassium channel subfamily K member 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121882, AC124527

  7. NM_001402776.1 → NP_001389705.1  potassium channel subfamily K member 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121882, AC124527

  8. NM_001402826.1 → NP_001389755.1  potassium channel subfamily K member 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC121882, AC124527

  9. NM_001402827.1 → NP_001389756.1  potassium channel subfamily K member 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC121882, AC124527

  10. NM_010607.4 → NP_034737.2  potassium channel subfamily K member 2 isoform 2

    See identical proteins and their annotated locations for NP_034737.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC121882, AC124527
    Consensus CDS
    CCDS48481.1
    UniProtKB/Swiss-Prot
    P97438
    Related
    ENSMUSP00000141849.2, ENSMUST00000192723.2
    Conserved Domains (1) summary
    pfam07885
    Location:124 → 181
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    188940127..189134951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97438.3 GenPept UniProtKB/Swiss-Prot:P97438

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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