U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 [ Mus musculus (house mouse) ]

Gene ID: 16520, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Kcnj4provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 4provided by MGI
Primary source
MGI:MGI:104743
See related
Ensembl:ENSMUSG00000044216 AllianceGenome:MGI:104743
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IRK3; Kcnf2; MB-IRK3
Summary
Predicted to enable PDZ domain binding activity and inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of ion transmembrane transport. Predicted to act upstream of or within potassium ion transport. Predicted to be located in basolateral plasma membrane; dendrite; and neuronal cell body. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; epididymis; telencephalon; and thymus. Orthologous to human KCNJ4 (potassium inwardly rectifying channel subfamily J member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 17.6) and cortex adult (RPKM 11.2) See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
15 E1; 15 37.74 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79364427..79396712, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79480226..79512511, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene casein kinase 1, epsilon Neighboring gene predicted gene 16059 Neighboring gene STARR-seq mESC enhancer starr_39185 Neighboring gene STARR-seq mESC enhancer starr_39186 Neighboring gene predicted gene, 41359 Neighboring gene STARR-seq mESC enhancer starr_39188 Neighboring gene KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 Neighboring gene STARR-seq mESC enhancer starr_39189 Neighboring gene DEAD box helicase 17 Neighboring gene DNA meiotic recombinase 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Arachidonic acid activates Kir2.3 channels by enhancing channel-phosphatidyl-inositol 4,5-bisphosphate interactions. Wang C, et al. Mol Pharmacol, 2008 Apr. PMID 18202303
  2. Identification and molecular localization of a pH-sensing domain for the inward rectifier potassium channel HIR. Coulter KL, et al. Neuron, 1995 Nov. PMID 7576658
  3. Mechanical deformation of ventricular myocytes modulates both TRPC6 and Kir2.3 channels. Dyachenko V, et al. Cell Calcium, 2009 Jan. PMID 18635261
  4. Cholinergic modulation of Kir2 channels selectively elevates dendritic excitability in striatopallidal neurons. Shen W, et al. Nat Neurosci, 2007 Nov. PMID 17906621
  5. Heterogeneity of IK1 in the mouse heart. Panama BK, et al. Am J Physiol Heart Circ Physiol, 2007 Dec. PMID 17890431

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. modulated by mechanical deformation of ventricular myocytes
    Title: Mechanical deformation of ventricular myocytes modulates both TRPC6 and Kir2.3 channels.
  2. Enhanced interaction with PIP(2) is the molecular mechanism for Kir2.3 channel activation by arachidonic acid.
    Title: Arachidonic acid activates Kir2.3 channels by enhancing channel-phosphatidyl-inositol 4,5-bisphosphate interactions.
  3. Kir2.3 channels do not contribute to cardiac inward rectifier potassium currents.
    Title: Heterogeneity of IK1 in the mouse heart.
  4. K+ currents attributable to Kir2.2/2.3 and K+-selective leak (Kleak) channels are prominent in layer V-VI pyramidal neurons in slices of prelimbic and infralimbic cortex
    Title: Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels.
  5. changes in these proteins and their modification may predispose striatal projection neurons to dysfunction and then degeneratation in Huntington disease
    Title: Neuronal vulnerability in mouse models of Huntington's disease: membrane channel protein changes.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
inward rectifier potassium channel 4
Names
IRK-3
Kir 2.3
inward rectifier K(+) channel Kir2.3
potassium channel, inwardly rectifying subfamily J member 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008427.5 → NP_032453.3  inward rectifier potassium channel 4

    See identical proteins and their annotated locations for NP_032453.3

    Status: VALIDATED

    Source sequence(s)
    AC165278
    Consensus CDS
    CCDS27641.1
    UniProtKB/TrEMBL
    Q8R434, Q8R435
    Related
    ENSMUSP00000094075.4, ENSMUST00000057801.8
    Conserved Domains (2) summary
    pfam01007
    Location:22 → 177
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:184 → 356
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79364427..79396712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520486.4 → XP_006520549.1  inward rectifier potassium channel 4 isoform X1

    See identical proteins and their annotated locations for XP_006520549.1

    UniProtKB/TrEMBL
    Q8R434, Q8R435
    Conserved Domains (2) summary
    pfam01007
    Location:22 → 177
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:184 → 356
    IRK_C; Inward rectifier potassium channel C-terminal domain

  2. XM_006520488.4 → XP_006520551.1  inward rectifier potassium channel 4 isoform X1

    See identical proteins and their annotated locations for XP_006520551.1

    UniProtKB/TrEMBL
    Q8R434, Q8R435
    Conserved Domains (2) summary
    pfam01007
    Location:22 → 177
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:184 → 356
    IRK_C; Inward rectifier potassium channel C-terminal domain

  3. XM_006520487.5 → XP_006520550.1  inward rectifier potassium channel 4 isoform X1

    See identical proteins and their annotated locations for XP_006520550.1

    UniProtKB/TrEMBL
    Q8R434, Q8R435
    Conserved Domains (2) summary
    pfam01007
    Location:22 → 177
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:184 → 356
    IRK_C; Inward rectifier potassium channel C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52189.1 GenPept UniProtKB/Swiss-Prot:P52189

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous