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Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 [ Mus musculus (house mouse) ]

Gene ID: 16517, updated on 11-Apr-2024

Summary

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Official Symbol
Kcnj16provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 16provided by MGI
Primary source
MGI:MGI:1314842
See related
Ensembl:ENSMUSG00000051497 AllianceGenome:MGI:1314842
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kir5.1; 6430410F18Rik
Summary
Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in several processes, including potassium ion import across plasma membrane; regulation of pH; and response to carbon dioxide. Predicted to act upstream of or within ion transport. Located in plasma membrane. Is expressed in floor plate; heart; and metanephros. Orthologous to human KCNJ16 (potassium inwardly rectifying channel subfamily J member 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 63.6), frontal lobe adult (RPKM 5.2) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 75.01 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (110858859..110918794)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (110968033..111027968)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:110420525-110420826 Neighboring gene predicted gene 11682 Neighboring gene predicted gene, 46300 Neighboring gene STARR-seq mESC enhancer starr_31046 Neighboring gene STARR-seq mESC enhancer starr_31047 Neighboring gene STARR-seq mESC enhancer starr_31048 Neighboring gene STARR-seq mESC enhancer starr_31049 Neighboring gene STARR-positive B cell enhancer ABC_E5296 Neighboring gene STARR-positive B cell enhancer ABC_E4011 Neighboring gene STARR-seq mESC enhancer starr_31050 Neighboring gene STARR-seq mESC enhancer starr_31052 Neighboring gene STARR-seq mESC enhancer starr_31053 Neighboring gene predicted gene, 53651 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 2 Neighboring gene eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Downregulation of inwardly rectifying potassium channel 5.1 expression in C57BL/6J cochlear lateral wall. Pan CC, et al. J Huazhong Univ Sci Technolog Med Sci, 2016 Jun. PMID 27376812
  2. Renal phenotype in mice lacking the Kir5.1 (Kcnj16) K+ channel subunit contrasts with that observed in SeSAME/EAST syndrome. Paulais M, et al. Proc Natl Acad Sci U S A, 2011 Jun 21. PMID 21633011, Free PMC Article
  3. Respiratory responses to hypercapnia and hypoxia in mice with genetic ablation of Kir5.1 (Kcnj16). Trapp S, et al. Exp Physiol, 2011 Apr. PMID 21239463, Free PMC Article
  4. Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity. D'Adamo MC, et al. J Biol Chem, 2011 Jan 7. PMID 21047793, Free PMC Article
  5. Deletion of Kir5.1 Impairs Renal Ability to Excrete Potassium during Increased Dietary Potassium Intake. Wu P, et al. J Am Soc Nephrol, 2019 Aug. PMID 31239388, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA N6-methyladenine methylase N6AMT1 controls neuropathic pain through epigenetically modifying Kcnj16 in dorsal horn neurons.
    Title: DNA N6-methyladenine methylase N6AMT1 controls neuropathic pain through epigenetically modifying Kcnj16 in dorsal horn neurons.
  2. Kcnj16 (Kir5.1) Gene Ablation Causes Subfertility and Increases the Prevalence of Morphologically Abnormal Spermatozoa.
    Title: Kcnj16 (Kir5.1) Gene Ablation Causes Subfertility and Increases the Prevalence of Morphologically Abnormal Spermatozoa.
  3. Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule.
    Title: Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule.
  4. Kir4.1 and Kir5.1 are essential components of the potassium-sensing mechanism in the distal convoluted tubule, and Kir5.1 is indispensable for regulation of renal potassium excretion and maintaining potassium homeostasis
    Title: Deletion of Kir5.1 Impairs Renal Ability to Excrete Potassium during Increased Dietary Potassium Intake.
  5. that Nedd4-2 binds to Kir5.1 at the phosphothreonine motif of the COOH terminus, and the association of Nedd4-2 with Kir5.1 facilitates the ubiquitination of Kir4.1, thereby regulating its plasma expression in the distal convoluted tubule
    Title: Kir5.1 regulates Nedd4-2-mediated ubiquitination of Kir4.1 in distal nephron.
  6. HNF1beta renal knockout mouse exhibits down-regulation of Kcnj16.Thus, HNF1beta is a transcriptional activator of Kcnj16.
    Title: Loss of transcriptional activation of the potassium channel Kir5.1 by HNF1β drives autosomal dominant tubulointerstitial kidney disease.
  7. Results demonstrate that, in addition to astrocytes, oligodendrocytes express both homomeric Kir4.1 and heteromeric Kir4.1/Kir5.1 channels.
    Title: Expression of Kir4.1 and Kir5.1 inwardly rectifying potassium channels in oligodendrocytes, the myelinating cells of the CNS.
  8. Down-regulation of Kir5.1 is associated with the decline in auditory function in aging mice.
    Title: Downregulation of inwardly rectifying potassium channel 5.1 expression in C57BL/6J cochlear lateral wall.
  9. thyroglobulin trafficking might be modulated by Kir4.1/5.1.
    Title: Molecular insights into the possible role of Kir4.1 and Kir5.1 in thyroid hormone biosynthesis.
  10. Kir5.1 is inhibited in cortical collecting duct cells by dopamine
    Title: Direct inhibition of basolateral Kir4.1/5.1 and Kir4.1 channels in the cortical collecting duct by dopamine.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of pH ISO
Inferred from Sequence Orthology
more info
  
involved_in response to carbon dioxide ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
inward rectifier potassium channel 16
Names
inward rectifier K(+) channel Kir5.1
potassium channel, inwardly rectifying subfamily J member 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252207.1 → NP_001239136.1  inward rectifier potassium channel 16

    See identical proteins and their annotated locations for NP_001239136.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript. Variants 1-5 encode the same protein.
    Source sequence(s)
    AK032192, AK078905, AL592422, AW122947, BB848241
    Consensus CDS
    CCDS25593.1
    UniProtKB/Swiss-Prot
    Q8BH37, Q9Z307
    UniProtKB/TrEMBL
    Q8CIB3
    Related
    ENSMUSP00000136382.2, ENSMUST00000180023.8
    Conserved Domains (2) summary
    pfam01007
    Location:37 → 173
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:182 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

  2. NM_001252208.1 → NP_001239137.1  inward rectifier potassium channel 16

    See identical proteins and their annotated locations for NP_001239137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AL592422, AW122947, BB850391
    Consensus CDS
    CCDS25593.1
    UniProtKB/Swiss-Prot
    Q8BH37, Q9Z307
    UniProtKB/TrEMBL
    Q8CIB3
    Related
    ENSMUSP00000137414.2, ENSMUST00000178798.2
    Conserved Domains (2) summary
    pfam01007
    Location:37 → 173
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:182 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

  3. NM_001252209.2 → NP_001239138.1  inward rectifier potassium channel 16

    See identical proteins and their annotated locations for NP_001239138.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AK045447, AL592422, AW122947
    Consensus CDS
    CCDS25593.1
    UniProtKB/Swiss-Prot
    Q8BH37, Q9Z307
    UniProtKB/TrEMBL
    Q8CIB3
    Related
    ENSMUSP00000102246.2, ENSMUST00000106635.2
    Conserved Domains (2) summary
    pfam01007
    Location:37 → 173
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:182 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

  4. NM_001252210.2 → NP_001239139.1  inward rectifier potassium channel 16

    See identical proteins and their annotated locations for NP_001239139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AL592422
    Consensus CDS
    CCDS25593.1
    UniProtKB/Swiss-Prot
    Q8BH37, Q9Z307
    UniProtKB/TrEMBL
    Q8CIB3
    Conserved Domains (2) summary
    pfam01007
    Location:37 → 173
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:182 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

  5. NM_010604.3 → NP_034734.3  inward rectifier potassium channel 16

    See identical proteins and their annotated locations for NP_034734.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.
    Source sequence(s)
    AK078905, AL592422
    Consensus CDS
    CCDS25593.1
    UniProtKB/Swiss-Prot
    Q8BH37, Q9Z307
    UniProtKB/TrEMBL
    Q8CIB3
    Related
    ENSMUSP00000102247.2, ENSMUST00000106636.8
    Conserved Domains (2) summary
    pfam01007
    Location:37 → 173
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:182 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    110858859..110918794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156350.1 → XP_036012243.1  inward rectifier potassium channel 16 isoform X1

    UniProtKB/Swiss-Prot
    Q8BH37, Q9Z307
    UniProtKB/TrEMBL
    Q8CIB3
    Conserved Domains (2) summary
    pfam01007
    Location:37 → 173
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:182 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z307.2 GenPept UniProtKB/Swiss-Prot:Q9Z307

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