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Kcnh3 potassium voltage-gated channel, subfamily H (eag-related), member 3 [ Mus musculus (house mouse) ]

Gene ID: 16512, updated on 11-Apr-2024

Summary

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Official Symbol
Kcnh3provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily H (eag-related), member 3provided by MGI
Primary source
MGI:MGI:1341723
See related
Ensembl:ENSMUSG00000037579 AllianceGenome:MGI:1341723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Elk2; Melk2; Kv12.2; C030044P22Rik
Summary
The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. An increase in cognitive function was observed when this gene was knocked out, while deletion of the gene resulted in hippocampal hyperexcitability and epilepsy. [provided by RefSeq, Sep 2015]
Expression
Biased expression in frontal lobe adult (RPKM 30.6), cortex adult (RPKM 30.2) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Kcnh3 in Genome Data Viewer
Location:
15 F1; 15 56.08 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99122396..99140699)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99224517..99242818)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C22 Neighboring gene spermatogenesis associated, serine-rich 2 Neighboring gene predicted gene, 57817 Neighboring gene predicted gene, 25183 Neighboring gene STARR-seq mESC enhancer starr_39699 Neighboring gene predicted gene, 46538 Neighboring gene RIKEN cDNA 1700120C14 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:99082061-99082244 Neighboring gene STARR-positive B cell enhancer ABC_E1486 Neighboring gene STARR-positive B cell enhancer ABC_E7417 Neighboring gene microspherule protein 1 Neighboring gene predicted gene, 25999 Neighboring gene family with sequence similarity 186, member B Neighboring gene pre-mRNA processing factor 40B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. Zhang X, et al. Nat Neurosci, 2010 Sep. PMID 20676103, Free PMC Article
  2. Triple N-glycosylation in the long S5-P loop regulates the activation and trafficking of the Kv12.2 potassium channel. Noma K, et al. J Biol Chem, 2009 Nov 27. PMID 19808681, Free PMC Article
  3. Disruption of the ether-a-go-go K+ channel gene BEC1/KCNH3 enhances cognitive function. Miyake A, et al. J Neurosci, 2009 Nov 18. PMID 19923296, Free PMC Article
  4. Functional analysis of a mouse brain Elk-type K+ channel. Trudeau MC, et al. J Neurosci, 1999 Apr 15. PMID 10191308, Free PMC Article
  5. KCNE1 and KCNE3 beta-subunits regulate membrane surface expression of Kv12.2 K(+) channels in vitro and form a tripartite complex in vivo. Clancy SM, et al. PLoS One, 2009 Jul 22. PMID 19623261, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kv12-encoded K+ channels drive the day-night switch in the repetitive firing rates of SCN neurons.
    Title: Kv12-encoded K+ channels drive the day-night switch in the repetitive firing rates of SCN neurons.
  2. Authors identified ligands of the TGFbeta- and IGF-family, Foxo1, Foxo3 and Kcnh3 as novel FOXG1-target genes during telencephalic development and showed that FOXG1 interferes with Foxo1 and Tgfbeta transcription.
    Title: The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons.
  3. We found the voltage-gated K+ channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons.
    Title: Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy.
  4. Data suggest that only glycosylated Kv12.2 channels (Kcnh3) show proper voltage dependence and are utilized in vivo.
    Title: Triple N-glycosylation in the long S5-P loop regulates the activation and trafficking of the Kv12.2 potassium channel.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily H member 3
Names
ELK channel 2
ether a go-go like
ether-a-go-go-like potassium channel 2
voltage-gated potassium channel subunit Kv12.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010601.4 → NP_034731.3  potassium voltage-gated channel subfamily H member 3

    See identical proteins and their annotated locations for NP_034731.3

    Status: REVIEWED

    Source sequence(s)
    AC161198
    Consensus CDS
    CCDS27817.1
    UniProtKB/Swiss-Prot
    B2RU85, E9QMZ8, Q6U1M1, Q9WVJ0
    Related
    ENSMUSP00000040548.4, ENSMUST00000041415.5
    Conserved Domains (3) summary
    TIGR03896
    Location:617 → 712
    cyc_nuc_ocin; bacteriocin-type transport-associated protein
    cl26073
    Location:227 → 662
    Ank_2; Ankyrin repeats (3 copies)
    cl28304
    Location:41 → 134
    PRK15347; two component system sensor kinase SsrA; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99122396..99140699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520483.5 → XP_006520546.1  potassium voltage-gated channel subfamily H member 3 isoform X1

    Conserved Domains (3) summary
    PLN03192
    Location:233 → 668
    PLN03192; Voltage-dependent potassium channel; Provisional
    TIGR03896
    Location:623 → 718
    cyc_nuc_ocin; bacteriocin-type transport-associated protein
    pfam13426
    Location:40 → 135
    PAS_9; PAS domain

  2. XM_036159170.1 → XP_036015063.1  potassium voltage-gated channel subfamily H member 3 isoform X2

    Conserved Domains (3) summary
    PLN03192
    Location:173 → 608
    PLN03192; Voltage-dependent potassium channel; Provisional
    PRK13557
    Location:4 → 74
    PRK13557; histidine kinase; Provisional
    TIGR03896
    Location:563 → 658
    cyc_nuc_ocin; bacteriocin-type transport-associated protein

  3. XM_036159171.1 → XP_036015064.1  potassium voltage-gated channel subfamily H member 3 isoform X3

    Conserved Domains (3) summary
    PLN03192
    Location:167 → 602
    PLN03192; Voltage-dependent potassium channel; Provisional
    PRK13557
    Location:4 → 74
    PRK13557; histidine kinase; Provisional
    TIGR03896
    Location:557 → 652
    cyc_nuc_ocin; bacteriocin-type transport-associated protein

  4. XM_030248344.2 → XP_030104204.1  potassium voltage-gated channel subfamily H member 3 isoform X3

    Conserved Domains (3) summary
    PLN03192
    Location:167 → 602
    PLN03192; Voltage-dependent potassium channel; Provisional
    PRK13557
    Location:4 → 74
    PRK13557; histidine kinase; Provisional
    TIGR03896
    Location:557 → 652
    cyc_nuc_ocin; bacteriocin-type transport-associated protein

  5. XM_006520484.4 → XP_006520547.1  potassium voltage-gated channel subfamily H member 3 isoform X2

    Conserved Domains (3) summary
    PLN03192
    Location:173 → 608
    PLN03192; Voltage-dependent potassium channel; Provisional
    PRK13557
    Location:4 → 74
    PRK13557; histidine kinase; Provisional
    TIGR03896
    Location:563 → 658
    cyc_nuc_ocin; bacteriocin-type transport-associated protein

  6. XM_030248343.2 → XP_030104203.1  potassium voltage-gated channel subfamily H member 3 isoform X3

    Conserved Domains (3) summary
    PLN03192
    Location:167 → 602
    PLN03192; Voltage-dependent potassium channel; Provisional
    PRK13557
    Location:4 → 74
    PRK13557; histidine kinase; Provisional
    TIGR03896
    Location:557 → 652
    cyc_nuc_ocin; bacteriocin-type transport-associated protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVJ0.3 GenPept UniProtKB/Swiss-Prot:Q9WVJ0

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