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Kcna6 potassium voltage-gated channel, shaker-related, subfamily, member 6 [ Mus musculus (house mouse) ]

Gene ID: 16494, updated on 18-Apr-2024

Summary

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Official Symbol
Kcna6provided by MGI
Official Full Name
potassium voltage-gated channel, shaker-related, subfamily, member 6provided by MGI
Primary source
MGI:MGI:96663
See related
Ensembl:ENSMUSG00000038077 AllianceGenome:MGI:96663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kv1.6; MK1.6
Summary
Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within ion transport and regulation of ion transmembrane transport. Located in axon terminus. Is expressed in several structures, including central nervous system; embryo mesenchyme; hindlimb muscle; neural retina; and trigeminal nerve. Orthologous to human KCNA6 (potassium voltage-gated channel subfamily A member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 9.9), cortex adult (RPKM 8.5) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 F3; 6 61.72 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126685292..126717610, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126708328..126740834, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33496 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 1 Neighboring gene predicted gene, 33581 Neighboring gene predicted gene, 20190 Neighboring gene STARR-seq mESC enhancer starr_17397 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Studying Independent Kcna6 Knock-out Mice Reveals Toxicity of Exogenous LacZ to Central Nociceptor Terminals and Differential Effects of Kv1.6 on Acute and Neuropathic Pain Sensation. Peck LJ, et al. J Neurosci, 2021 Nov 3. PMID 34544832, Free PMC Article
  2. Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes. Vysotskaya Z, et al. J Cell Physiol, 2018 May. PMID 29139549
  3. Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons. Brew HM, et al. J Neurophysiol, 2007 Sep. PMID 17634333
  4. Cloning, sequence and chromosomal localization of MK6, a murine potassium channel gene. Migeon MB, et al. Epilepsy Res Suppl, 1992. PMID 1285906
  5. Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephaly. Petersson S, et al. Eur J Neurosci, 2003 Dec. PMID 14686897

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon terminus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of potassium channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily A member 6
Names
voltage-gated potassium channel subunit Kv1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410072.1 → NP_001397001.1  potassium voltage-gated channel subfamily A member 6

    Status: VALIDATED

    Source sequence(s)
    AC079438, AC124756
    UniProtKB/Swiss-Prot
    Q61923

  2. NM_001410074.1 → NP_001397003.1  potassium voltage-gated channel subfamily A member 6

    Status: VALIDATED

    Source sequence(s)
    AC079438, AC124756
    UniProtKB/Swiss-Prot
    Q61923
    Related
    ENSMUSP00000107861.2, ENSMUST00000112242.2

  3. NM_001410075.1 → NP_001397004.1  potassium voltage-gated channel subfamily A member 6

    Status: VALIDATED

    Source sequence(s)
    AC079438, AC124756
    UniProtKB/Swiss-Prot
    Q61923

  4. NM_013568.7 → NP_038596.1  potassium voltage-gated channel subfamily A member 6

    See identical proteins and their annotated locations for NP_038596.1

    Status: VALIDATED

    Source sequence(s)
    AC079438, AC124756
    Consensus CDS
    CCDS20556.1
    UniProtKB/Swiss-Prot
    Q61923
    Related
    ENSMUSP00000036872.6, ENSMUST00000040751.6
    Conserved Domains (2) summary
    cd18407
    Location:41 → 170
    BTB_POZ_KCNA6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 6 (KCNA6)
    pfam00520
    Location:258 → 468
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    126685292..126717610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61923.1 GenPept UniProtKB/Swiss-Prot:Q61923

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