Jrk jerky [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Jrkprovided by MGI
Official Full Name: jerkyprovided by MGI
Primary source: MGI:MGI:106214
See related: Ensembl:ENSMUSG00000046380 AllianceGenome:MGI:106214
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables mRNA binding activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Located in cytoplasm and nucleus. Part of ribonucleoprotein complex. Is expressed in brain; early conceptus; eye; and genitourinary system. Orthologous to human JRK (Jrk helix-turn-helix protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 4.1), ovary adult (RPKM 2.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 34.26 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (74574261..74581171, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (74702412..74709322, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

JRK protein associates with a specific chromosomal centromeric locus in the cell cycle G(2) phase.
Title: Complex regulation and nuclear localization of JRK protein.
Jerky has a role in epilepsy and consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs
Title: The RNA binding domain of Jerky consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1) 1 citation

General gene information

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Markers

Jrk (e-PCR), detects polymorphism
- UniSTS:143644

U35730 (e-PCR)
- UniSTS:125732

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
NOT located_in ribosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: jerky protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008415.6 → NP_032441.4 jerky protein

See identical proteins and their annotated locations for NP_032441.4

Status: VALIDATED

Source sequence(s)

AC118022, AK168885

Consensus CDS

CCDS27524.1

UniProtKB/Swiss-Prot

Q60976

UniProtKB/TrEMBL

Q543Z9, Q8C995

Related

ENSMUSP00000051842.3, ENSMUST00000050234.4

Conserved Domains (3) summary

smart00674
Location:83 → 147

CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases

pfam03184
Location:213 → 382

DDE_1; DDE superfamily endonuclease

pfam04218
Location:14 → 66

CENP-B_N; CENP-B N-terminal DNA-binding domain