Itgb1 integrin beta 1 (fibronectin receptor beta) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itgb1provided by MGI
Official Full Name: integrin beta 1 (fibronectin receptor beta)provided by MGI
Primary source: MGI:MGI:96610
See related: Ensembl:ENSMUSG00000025809 AllianceGenome:MGI:96610
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD29; Fnrb; gpIIa; Gm9863; 4633401G24Rik
Summary: Enables integrin binding activity. Contributes to laminin binding activity. Involved in several processes, including basement membrane organization; cellular response to low-density lipoprotein particle stimulus; and receptor internalization. Acts upstream of or within with a negative effect on reactive gliosis and regulation of spontaneous synaptic transmission. Acts upstream of or within several processes, including cell morphogenesis involved in differentiation; regulation of ion transmembrane transport; and striated muscle cell differentiation. Located in several cellular components, including Schaffer collateral - CA1 synapse; intercalated disc; and myelin sheath abaxonal region. Part of integrin alpha7-beta1 complex. Is integral component of synaptic membrane. Colocalizes with cytoplasmic vesicle and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and limb. Used to study Hirschsprung's disease. Orthologous to human ITGB1 (integrin subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 156.5), placenta adult (RPKM 75.5) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E2; 8 76.09 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (129412135..129460060)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (128685654..128733579)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

N-cadherin and beta1 integrin coordinately regulate growth plate cartilage architecture.
Title: N-cadherin and β1 integrin coordinately regulate growth plate cartilage architecture.
Sialylation on vesicular integrin beta1 determined endocytic entry of small extracellular vesicles into recipient cells.
Title: Sialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells.
The Role of alpha3beta1 Integrin Modulation on Fabry Disease Podocyte Injury and Kidney Impairment.
Title: The Role of α3β1 Integrin Modulation on Fabry Disease Podocyte Injury and Kidney Impairment.
Rab25 is involved in hypospadias via the beta1 integrin/EGFR pathway.
Title: Rab25 is involved in hypospadias via the β1 integrin/EGFR pathway.
Q-switched 1064 nm Nd: YAG laser restores skin photoageing by activating autophagy by TGFbeta1 and ITGB1.
Title: Q-switched 1064 nm Nd: YAG laser restores skin photoageing by activating autophagy by TGFβ1 and ITGB1.
Heart Failure Promotes Cancer Progression in an Integrin beta1-Dependent Manner.
Title: Heart Failure Promotes Cancer Progression in an Integrin β1-Dependent Manner.
PACSIN2 regulates platelet integrin beta1 hemostatic function.
Title: PACSIN2 regulates platelet integrin β1 hemostatic function.
TRPV4 regulates beta1 integrin-mediated cell-matrix adhesions and collagen remodeling.
Title: TRPV4 regulates β1 integrin-mediated cell-matrix adhesions and collagen remodeling.
Fertilization, but Not Post-Implantation Development, Can Occur in the Absence of Sperm and Oocyte Beta1 Integrin in Mice.
Title: Fertilization, but Not Post-Implantation Development, Can Occur in the Absence of Sperm and Oocyte Beta1 Integrin in Mice.
Integrin beta1 regulates marginal zone B cell differentiation and PI3K signaling.
Title: Integrin β1 regulates marginal zone B cell differentiation and PI3K signaling.

Submit: New GeneRIF Correction See all GeneRIFs (497)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (27) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224259

Itgb1 (e-PCR), detects polymorphism
- UniSTS:226053

Itgb1 (e-PCR), detects polymorphism
- UniSTS:143627

Itgb1 (e-PCR), detects polymorphism
- UniSTS:143628

Itgb1 (e-PCR), detects polymorphism
- UniSTS:143629

NoName (e-PCR)
- UniSTS:236047

UniSTS:256618 (e-PCR)
- UniSTS:256618

Itgb1 (e-PCR), detects polymorphism
- UniSTS:256618

RH124911 (e-PCR)
- UniSTS:161733

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to C-X3-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to C-X3-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables alpha-actinin binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables collagen binding involved in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding involved in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding involved in cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
enables kinase binding	ISO Inferred from Sequence Orthology more info
contributes_to laminin binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to laminin binding	IDA Inferred from Direct Assay more info	PubMed
enables laminin binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CD40 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium-independent cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle cell myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection organization	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-matrix adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to low-density lipoprotein particle stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dendrite morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within formation of radial glial scaffolds	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in maintenance of postsynaptic specialization structure	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myoblast fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of Rho protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell projection organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of glutamate uptake involved in transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in protein transport within lipid bilayer	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect reactive gliosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of collagen catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of inward rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect regulation of spontaneous synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse pruning	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse pruning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to muscle activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue homeostasis	ISO Inferred from Sequence Orthology more info
NOT involved_in transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual learning	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cerebellar climbing fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in cerebellar climbing fiber to Purkinje cell synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
colocalizes_with cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info	PubMed
located_in glial cell projection	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in glycinergic synapse	ISO Inferred from Sequence Orthology more info
located_in hemidesmosome	ISO Inferred from Sequence Orthology more info
part_of integrin alpha1-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alpha10-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alpha11-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alpha2-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alpha3-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alpha5-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alpha7-beta1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha7-beta1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of integrin alpha9-beta1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha9-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin alphav-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in myelin sheath abaxonal region	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
colocalizes_with perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
colocalizes_with plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
colocalizes_with ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: integrin beta-1

Names: VLA-4 subunit beta; fibronectin receptor subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010578.2 → NP_034708.1 integrin beta-1 precursor

See identical proteins and their annotated locations for NP_034708.1

Status: VALIDATED

Source sequence(s)

AC156608, BC050906

Consensus CDS

CCDS22791.1

UniProtKB/Swiss-Prot

F6R105, P09055, Q3TIW5, Q3TWH6, Q60993, Q61126, Q8BTU0, Q8BVU1

Related

ENSMUSP00000087457.6, ENSMUST00000090006.12

Conserved Domains (5) summary

smart00187
Location:34 → 464

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07974
Location:602 → 630

EGF_2; EGF-like domain

pfam07965
Location:640 → 727

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:757 → 795

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:466 → 495

I-EGF_1; Integrin beta epidermal growth factor like domain 1