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Itga5 integrin alpha 5 (fibronectin receptor alpha) [ Mus musculus (house mouse) ]

Gene ID: 16402, updated on 11-Apr-2024

Summary

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Official Symbol
Itga5provided by MGI
Official Full Name
integrin alpha 5 (fibronectin receptor alpha)provided by MGI
Primary source
MGI:MGI:96604
See related
Ensembl:ENSMUSG00000000555 AllianceGenome:MGI:96604
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fnra; VLA5; Cd49e
Summary
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain, which is proteolytically processed to generate light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signaling. Integrin alpha 5 and integrin alpha V chains are produced by distinct genes. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Broad expression in bladder adult (RPKM 50.0), limb E14.5 (RPKM 25.3) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 F3; 15 58.9 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (103252713..103275218, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (103344286..103366791, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 84 Neighboring gene zinc finger protein 385A Neighboring gene STARR-positive B cell enhancer ABC_E5521 Neighboring gene STARR-positive B cell enhancer mm9_chr15:103177678-103177979 Neighboring gene microRNA 6963 Neighboring gene STARR-seq mESC enhancer starr_39882 Neighboring gene STARR-seq mESC enhancer starr_39884 Neighboring gene gametocyte specific factor 1 Neighboring gene MARCKS-like 1, pseudogene 3 Neighboring gene gametocyte specific factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. B Cell αv Integrins Regulate TLR-Driven Autoimmunity. Acharya M, et al. J Immunol, 2020 Oct 1. PMID 32859730, Free PMC Article
  2. Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation. Zhang C, et al. Circ Res, 2020 Sep 25. PMID 32673515
  3. Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis. Budatha M, et al. J Am Heart Assoc, 2018 Jan 30. PMID 29382667, Free PMC Article
  4. Force regulated conformational change of integrin α(V)β(3). Chen Y, et al. Matrix Biol, 2017 Jul. PMID 27423389, Free PMC Article
  5. Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints. Candela ME, et al. PLoS One, 2016. PMID 27280771, Free PMC Article

See all (242) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mesenchymal stem cell-derived extracellular vesicles exert pro-angiogenic and pro-lymphangiogenic effects in ischemic tissues by transferring various microRNAs and proteins including ITGa5 and NRP1.
    Title: Mesenchymal stem cell-derived extracellular vesicles exert pro-angiogenic and pro-lymphangiogenic effects in ischemic tissues by transferring various microRNAs and proteins including ITGa5 and NRP1.
  2. Role of Formyl Peptide Receptors and beta-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with alphaVbeta3-Integrin.
    Title: Role of Formyl Peptide Receptors and β-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with αVβ3-Integrin.
  3. gamma-Bungarotoxin impairs the vascular endothelial barrier function by inhibiting integrin alpha5.
    Title: γ-Bungarotoxin impairs the vascular endothelial barrier function by inhibiting integrin α5.
  4. Actomyosin-mediated cellular tension promotes Yap nuclear translocation and myocardial proliferation through alpha5 integrin signaling.
    Title: Actomyosin-mediated cellular tension promotes Yap nuclear translocation and myocardial proliferation through α5 integrin signaling.
  5. SERPINA3C ameliorates adipose tissue inflammation through the Cathepsin G/Integrin/AKT pathway.
    Title: SERPINA3C ameliorates adipose tissue inflammation through the Cathepsin G/Integrin/AKT pathway.
  6. FGA inhibits metastases and induces autophagic cell death in gastric cancer via inhibiting ITGA5 to regulate the FAK/ERK pathway.
    Title: FGA inhibits metastases and induces autophagic cell death in gastric cancer via inhibiting ITGA5 to regulate the FAK/ERK pathway.
  7. The Mechanism of Leptin on Inhibiting Fibrosis and Promoting Browning of White Fat by Reducing ITGA5 in Mice.
    Title: The Mechanism of Leptin on Inhibiting Fibrosis and Promoting Browning of White Fat by Reducing ITGA5 in Mice.
  8. RhoJ Regulates alpha5beta1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis.
    Title: RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis.
  9. Coupling of Integrin alpha5 to Annexin A2 by Flow Drives Endothelial Activation.
    Title: Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation.
  10. B Cell alphav Integrins Regulate TLR-Driven Autoimmunity.
    Title: B Cell αv Integrins Regulate TLR-Driven Autoimmunity.
Submit: New GeneRIF Correction See all GeneRIFs (92)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in CD40 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell-cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell-substrate junction assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of angiogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to muscle activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
part_of integrin alpha5-beta1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with ruffle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
integrin alpha-5
Names
CD49 antigen-like family member E
fibronectin receptor alpha polypeptide
fibronectin receptor subunit alpha
integrin alpha-F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001314041.1 → NP_001300970.1  integrin alpha-5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, uses a downstream translation start site, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC131721, AK142241, BC050943
    UniProtKB/TrEMBL
    Q80YP5
    Conserved Domains (2) summary
    smart00191
    Location:68 → 122
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:169 → 597
    Integrin_alpha2; Integrin alpha

  2. NM_010577.4 → NP_034707.5  integrin alpha-5 isoform 1 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC131721, AK142241, BC050943
    Consensus CDS
    CCDS27903.1
    UniProtKB/Swiss-Prot
    E9QN40, P11688
    UniProtKB/TrEMBL
    Q80YP5
    Related
    ENSMUSP00000023128.7, ENSMUST00000023128.8
    Conserved Domains (2) summary
    smart00191
    Location:392 → 446
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:493 → 925
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    103252713..103275218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11688.3 GenPept UniProtKB/Swiss-Prot:P11688

Gene LinkOut

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