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Irx2 Iroquois homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 16372, updated on 18-Apr-2024

Summary

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Official Symbol
Irx2provided by MGI
Official Full Name
Iroquois homeobox 2provided by MGI
Primary source
MGI:MGI:1197526
See related
Ensembl:ENSMUSG00000001504 AllianceGenome:MGI:1197526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within proximal/distal pattern formation involved in metanephric nephron development and specification of loop of Henle identity. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; autopod; central nervous system; genitourinary system; and respiratory system. Orthologous to human IRX2 (iroquois homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 35.9), mammary gland adult (RPKM 23.4) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 C1; 13 39.23 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (72771463..72782315)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (72624430..72634196)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41000 Neighboring gene predicted gene, 38580 Neighboring gene STARR-seq mESC enhancer starr_34980 Neighboring gene predicted gene, 20554 Neighboring gene predicted gene, 41001 Neighboring gene RIKEN cDNA D730050B12 gene Neighboring gene STARR-seq mESC enhancer starr_34983

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IRX2 activated by jumonji domain-containing protein 2A is crucial for cardiac hypertrophy and dysfunction in response to the hypertrophic stimuli. Wang K, et al. Int J Cardiol, 2023 Jan 15. PMID 36181956
  2. Iroquois Homeobox Protein 2 Identified as a Potential Biomarker for Parkinson's Disease. Sim H, et al. Int J Mol Sci, 2020 May 14. PMID 32422864, Free PMC Article
  3. Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Bosse A, et al. Mech Dev, 1997 Dec. PMID 9486539
  4. Iroquois genes influence proximo-distal morphogenesis during rat lung development. van Tuyl M, et al. Am J Physiol Lung Cell Mol Physiol, 2006 Apr. PMID 16299054
  5. Expression pattern of Irx1 and Irx2 during mouse digit development. Zülch A, et al. Mech Dev, 2001 Aug. PMID 11472848

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice.
    Title: IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice.
  2. IRX2 activated by jumonji domain-containing protein 2A is crucial for cardiac hypertrophy and dysfunction in response to the hypertrophic stimuli.
    Title: IRX2 activated by jumonji domain-containing protein 2A is crucial for cardiac hypertrophy and dysfunction in response to the hypertrophic stimuli.
  3. Iroquois Homeobox Protein 2 Identified as a Potential Biomarker for Parkinson's Disease.
    Title: Iroquois Homeobox Protein 2 Identified as a Potential Biomarker for Parkinson's Disease.
  4. generation and phenotypic analysis of an Irx2-deficient mouse strain. Irx2-deficient mice are viable, are fertile, and appear to be normal.
    Title: The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice.
  5. This homeobox protein is expressed during digit development.
    Title: Expression pattern of Irx1 and Irx2 during mouse digit development.
  6. This homeobox protein is expressed during early lung development.
    Title: Irx1 and Irx2 expression in early lung development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103290

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metanephros development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proximal/distal pattern formation involved in metanephric nephron development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in specification of loop of Henle identity IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
iroquois-class homeodomain protein IRX-2
Names
Iroquois related homeobox 2
homeodomain protein IRXA2
iroquois homeobox protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010574.4 → NP_034704.1  iroquois-class homeodomain protein IRX-2

    See identical proteins and their annotated locations for NP_034704.1

    Status: VALIDATED

    Source sequence(s)
    AK018266, AK148520, CT030229
    Consensus CDS
    CCDS26628.1
    UniProtKB/Swiss-Prot
    O55121, P81066, Q3UFG3, Q9ERN1, Q9JLL4
    Related
    ENSMUSP00000073976.5, ENSMUST00000074372.6
    Conserved Domains (3) summary
    smart00548
    Location:325 → 342
    IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
    COG5576
    Location:115 → 217
    COG5576; Homeodomain-containing transcription factor [Transcription]
    pfam05920
    Location:133 → 172
    Homeobox_KN; Homeobox KN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    72771463..72782315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247164.2 → XP_030103024.1  iroquois-class homeodomain protein IRX-2 isoform X1

    Conserved Domains (3) summary
    smart00548
    Location:231 → 248
    IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
    COG5576
    Location:21 → 123
    COG5576; Homeodomain-containing transcription factor [Transcription]
    pfam05920
    Location:39 → 78
    Homeobox_KN; Homeobox KN domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P81066.2 GenPept UniProtKB/Swiss-Prot:P81066

Gene LinkOut

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