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GBP6 guanylate binding protein family member 6 [ Homo sapiens (human) ]

Gene ID: 163351, updated on 10-Dec-2024

Summary

Official Symbol
GBP6provided by HGNC
Official Full Name
guanylate binding protein family member 6provided by HGNC
Primary source
HGNC:HGNC:25395
See related
Ensembl:ENSG00000183347 MIM:612467; AllianceGenome:HGNC:25395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP (Olszewski et al., 2006 [PubMed 16689661]).[supplied by OMIM, Dec 2008]
Expression
Restricted expression toward esophagus (RPKM 171.0) See more
Orthologs
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Genomic context

See GBP6 in Genome Data Viewer
Location:
1p22.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (89364059..89388160)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (89207077..89231426)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89829618..89853719)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene guanylate binding protein family member 6 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:89725724-89726225 Neighboring gene guanylate binding protein 5 Neighboring gene intraflagellar transport associated protein pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:89802881-89803381 Neighboring gene calpain small subunit 1 pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:89883292-89883872 Neighboring gene guanylate binding protein 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

General gene information

Clone Names

  • FLJ39135, DKFZp686G0786

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding  
enables GTPase activity  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in cellular response to type II interferon  
involved_in cellular response to type II interferon  
involved_in defense response to Gram-positive bacterium  
involved_in defense response to bacterium  
involved_in defense response to protozoan  
involved_in immune response  
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle  
located_in extracellular exosome PubMed 

General protein information

Preferred Names
guanylate-binding protein 6
Names
GBP-6
GTP-binding protein 6
guanine nucleotide-binding protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320257.2NP_001307186.1  guanylate-binding protein 6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses an downstream in-frame start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK299466, AK303987, AL691464, BX647907, DA447005
    UniProtKB/TrEMBL
    B4DRX0
    Conserved Domains (3) summary
    pfam02841
    Location:153449
    GBP_C; Guanylate-binding protein, C-terminal domain
    cd16269
    Location:159449
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21455
    Location:1151
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_198460.3NP_940862.2  guanylate-binding protein 6 isoform 1

    See identical proteins and their annotated locations for NP_940862.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI199897, AK131356, AL691464
    Consensus CDS
    CCDS723.1
    UniProtKB/Swiss-Prot
    A2RRM3, Q6ZN66, Q6ZN86, Q7Z3F0
    UniProtKB/TrEMBL
    B0AZP3
    Related
    ENSP00000359485.5, ENST00000370456.5
    Conserved Domains (3) summary
    pfam02841
    Location:283579
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:18281
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:289579
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    89364059..89388160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540835.4XP_011539137.1  guanylate-binding protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011539137.1

    UniProtKB/Swiss-Prot
    A2RRM3, Q6ZN66, Q6ZN86, Q7Z3F0
    UniProtKB/TrEMBL
    B0AZP3
    Conserved Domains (3) summary
    pfam02841
    Location:283579
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:18281
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:289579
    GBP_C; Guanylate-binding protein, C-terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    89207077..89231426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334712.1XP_054190687.1  guanylate-binding protein 6 isoform X1

    UniProtKB/TrEMBL
    B0AZP3
  2. XM_054334711.1XP_054190686.1  guanylate-binding protein 6 isoform X1

    UniProtKB/TrEMBL
    B0AZP3
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