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Inha inhibin alpha [ Mus musculus (house mouse) ]

Gene ID: 16322, updated on 21-Apr-2024

Summary

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Official Symbol
Inhaprovided by MGI
Official Full Name
inhibin alphaprovided by MGI
Primary source
MGI:MGI:96569
See related
Ensembl:ENSMUSG00000032968 AllianceGenome:MGI:96569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mice in which this gene has been ablated exhibit sex cord-stromal tumors and symptoms that mimic the human cancer cachexia syndrome. [provided by RefSeq, Aug 2016]
Expression
Biased expression in ovary adult (RPKM 2254.3) and adrenal adult (RPKM 71.2) See more
Orthologs
human all
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Genomic context

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Location:
1 C4; 1 39.16 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75483872..75487010)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75507077..75510366)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene chondroitin polymerizing factor Neighboring gene transmembrane protein 198 Neighboring gene obscurin-like 1 Neighboring gene STARR-seq mESC enhancer starr_01360 Neighboring gene STARR-positive B cell enhancer ABC_E5772 Neighboring gene STARR-positive B cell enhancer ABC_E5773 Neighboring gene STARR-positive B cell enhancer ABC_E4325 Neighboring gene serine/threonine kinase 11 interacting protein Neighboring gene predicted gene 15183

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular Genomic Study of Inhibin Molecule Production through Granulosa Cell Gene Expression in Inhibin-Deficient Mice. Talpur HS, et al. Molecules, 2022 Aug 30. PMID 36080362, Free PMC Article
  2. Inhibin Inactivation in Female Mice Leads to Elevated FSH Levels, Ovarian Overstimulation, and Pregnancy Loss. Walton KL, et al. Endocrinology, 2022 Apr 1. PMID 35255139, Free PMC Article
  3. Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract. Wijayarathna R, et al. Mol Cell Endocrinol, 2018 Jul 15. PMID 29111388
  4. Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice. Winbanks CE, et al. Sci Transl Med, 2016 Jul 20. PMID 27440729
  5. Murine Inhibin α-Subunit Haploinsufficiency Causes Transient Abnormalities in Prepubertal Testis Development Followed by Adult Testicular Decline. Itman C, et al. Endocrinology, 2015 Jun. PMID 25781564

See all (145) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular Genomic Study of Inhibin Molecule Production through Granulosa Cell Gene Expression in Inhibin-Deficient Mice.
    Title: Molecular Genomic Study of Inhibin Molecule Production through Granulosa Cell Gene Expression in Inhibin-Deficient Mice.
  2. absence of the inhibin alpha-subunit has marginal effects on activins in the epididymis and vas deferens, and regression of these tissues is associated with androgen deficiency.
    Title: Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract.
  3. These data suggest that activin-follistatin regulation may play a role during the development of Experimental autoimmune epididymo-orchitis.
    Title: Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice.
  4. This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3, as a model of immature Leydig cells.
    Title: Endogenous inhibins regulate steroidogenesis in mouse TM3 Leydig cells by altering SMAD2 signalling.
  5. The study is the first to identify an intratesticular role for inhibin/inhibin-alpha subunit, demonstrating that a threshold level of this protein is required for normal testis development and to sustain adult somatic testicular cell function.
    Title: Murine Inhibin α-Subunit Haploinsufficiency Causes Transient Abnormalities in Prepubertal Testis Development Followed by Adult Testicular Decline.
  6. inhibin is a broad regulatory marker in anterior pituitary cells
    Title: Characterization of the mechanism of inhibin α-subunit gene in mouse anterior pituitary cells by RNA interference.
  7. A novel role for GDF9 in causing reproductive defects and suppressing tumor initiation in the Inha(-/-) mouse model.
    Title: GDF9 modulates the reproductive and tumor phenotype of female inha-null mice.
  8. Data indicate that the inhibin-alpha promoter is activated synergistically by Wt1 and Sf1.
    Title: Expression of inhibin-alpha is regulated synergistically by Wilms' tumor gene 1 (Wt1) and steroidogenic factor-1 (Sf1) in sertoli cells.
  9. Inhibin alpha-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling.
    Title: Inhibin α-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling.
  10. relationship between inhibin and Sertoli cell activity
    Title: Action mechanism of inhibin α-subunit on the development of Sertoli cells and first wave of spermatogenesis in mice.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables inhibin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in hemoglobin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in male gonad development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of follicle-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
part_of inhibin A complex ISO
Inferred from Sequence Orthology
more info
  
part_of inhibin B complex ISO
Inferred from Sequence Orthology
more info
  
part_of inhibin-betaglycan-ActRII complex ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inhibin alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329843.2 → NP_001316772.1  inhibin alpha chain isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115011

  2. NM_010564.6 → NP_034694.3  inhibin alpha chain isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_034694.3

    Status: VALIDATED

    Source sequence(s)
    AC115011
    Consensus CDS
    CCDS15078.1
    UniProtKB/Swiss-Prot
    Q04997, Q6GTG7
    Related
    ENSMUSP00000040310.5, ENSMUST00000037330.5
    Conserved Domains (1) summary
    cl02510
    Location:263 → 366
    TGF_beta; Transforming growth factor beta like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    75483872..75487010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238675.3 → XP_011236977.1  inhibin alpha chain isoform X1

    Conserved Domains (1) summary
    cl40434
    Location:181 → 284
    TGF_beta_SF; transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04997.2 GenPept UniProtKB/Swiss-Prot:Q04997

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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