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Incenp inner centromere protein [ Mus musculus (house mouse) ]

Gene ID: 16319, updated on 11-Apr-2024

Summary

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Official Symbol
Incenpprovided by MGI
Official Full Name
inner centromere proteinprovided by MGI
Primary source
MGI:MGI:1313288
See related
Ensembl:ENSMUSG00000024660 AllianceGenome:MGI:1313288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C130081E20; 2700067E22Rik
Summary
Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including meiotic spindle midzone assembly; metaphase plate congression; and positive regulation of protein serine/threonine kinase activity. Predicted to act upstream of or within cell division. Located in several cellular components, including chromocenter; midbody; and synaptonemal complex. Is expressed in midbrain ventricular layer; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human INCENP (inner centromere protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 26.8), CNS E11.5 (RPKM 25.6) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Incenp in Genome Data Viewer
Location:
19 A; 19 6.1 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (9849659..9876853, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (9872295..9899489, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45524 Neighboring gene syntaxin-binding protein 3, pseudogene Neighboring gene STARR-seq mESC enhancer starr_45526 Neighboring gene STARR-seq mESC enhancer starr_45527 Neighboring gene STARR-seq mESC enhancer starr_45528 Neighboring gene STARR-seq mESC enhancer starr_45529 Neighboring gene STARR-seq mESC enhancer starr_45530 Neighboring gene STARR-seq mESC enhancer starr_45531 Neighboring gene secretoglobin, family 2A, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E1972 Neighboring gene STARR-seq mESC enhancer starr_45534 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene predicted gene, 50340 Neighboring gene STARR-positive B cell enhancer ABC_E5686 Neighboring gene predicted gene, 36913 Neighboring gene predicted gene, 41806

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning, expression, and promoter structure of a mammalian inner centromere protein (INCENP). Saffery R, et al. Mamm Genome, 1999 Apr. PMID 10087305
  2. Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells. Adams RR, et al. Chromosoma, 2001 May. PMID 11453556
  3. Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice. Cutts SM, et al. Hum Mol Genet, 1999 Jul. PMID 10369859
  4. The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes. Sharif B, et al. J Cell Sci, 2010 Dec 15. PMID 21123620, Free PMC Article
  5. Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis. Tang CJ, et al. Dev Biol, 2006 Feb 15. PMID 16386730

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metaphase chromosome alignment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle midzone assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of mitotic cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of mitotic sister chromatid separation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of protein phosphorylation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in central element IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromocenter IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromosome passenger complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in lateral element IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in meiotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
located_in synaptonemal complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
inner centromere protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369356.1 → NP_001356285.1  inner centromere protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132253
    Consensus CDS
    CCDS89338.1
    UniProtKB/Swiss-Prot
    Q7TN28, Q8BGN4, Q8CGI4, Q9WU62
    Related
    ENSMUSP00000157547.2, ENSMUST00000237439.2
    Conserved Domains (3) summary
    PTZ00121
    Location:513 → 656
    PTZ00121; MAEBL; Provisional
    pfam03941
    Location:795 → 849
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:6 → 41
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

  2. NM_016692.4 → NP_057901.2  inner centromere protein isoform 2

    See identical proteins and their annotated locations for NP_057901.2

    Status: VALIDATED

    Source sequence(s)
    AC132253
    Consensus CDS
    CCDS37912.1
    UniProtKB/Swiss-Prot
    Q9WU62
    Related
    ENSMUSP00000025562.8, ENSMUST00000025562.9
    Conserved Domains (4) summary
    pfam03941
    Location:795 → 846
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:6 → 41
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    cd16269
    Location:588 → 599
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:515 → 619
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    9849659..9876853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526708.2 → XP_006526771.2  inner centromere protein isoform X2

    Conserved Domains (4) summary
    PTZ00121
    Location:503 → 659
    PTZ00121; MAEBL; Provisional
    pfam03941
    Location:798 → 852
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam09726
    Location:394 → 595
    Macoilin; Macoilin family
    pfam12178
    Location:13 → 48
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

  2. XM_006526710.2 → XP_006526773.2  inner centromere protein isoform X4

    Conserved Domains (4) summary
    PTZ00121
    Location:520 → 625
    PTZ00121; MAEBL; Provisional
    pfam03941
    Location:762 → 816
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam09726
    Location:394 → 582
    Macoilin; Macoilin family
    pfam12178
    Location:13 → 48
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

  3. XM_011247154.1 → XP_011245456.1  inner centromere protein isoform X3

    Conserved Domains (4) summary
    PTZ00121
    Location:516 → 663
    PTZ00121; MAEBL; Provisional
    pfam03941
    Location:782 → 836
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam09726
    Location:394 → 599
    Macoilin; Macoilin family
    pfam12178
    Location:13 → 48
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

  4. XM_006526707.2 → XP_006526770.2  inner centromere protein isoform X1

    Conserved Domains (4) summary
    PTZ00121
    Location:520 → 663
    PTZ00121; MAEBL; Provisional
    pfam03941
    Location:802 → 856
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam09726
    Location:394 → 599
    Macoilin; Macoilin family
    pfam12178
    Location:13 → 48
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WU62.2 GenPept UniProtKB/Swiss-Prot:Q9WU62

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