U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SLC16A11 solute carrier family 16 member 11 [ Homo sapiens (human) ]

Gene ID: 162515, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
SLC16A11provided by HGNC
Official Full Name
solute carrier family 16 member 11provided by HGNC
Primary source
HGNC:HGNC:23093
See related
Ensembl:ENSG00000174326 MIM:615765; AllianceGenome:HGNC:23093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT11; MCT 11
Summary
Enables pyruvate transmembrane transporter activity. Involved in lipid metabolic process. Located in endoplasmic reticulum membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney (RPKM 1.1), lung (RPKM 1.1) and 22 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SLC16A11 in Genome Data Viewer
Location:
17p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7041621..7044092, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (6942295..6944766, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6944940..6947411, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene BCL6B transcription repressor Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:6938773-6939273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11596 Neighboring gene solute carrier family 16 member 13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8083 Neighboring gene uncharacterized LOC124903909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8085 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11599 Neighboring gene C-type lectin domain containing 10A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11601 Neighboring gene asialoglycoprotein receptor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7015987-7016487 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7018293-7019079

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Downregulation of SLC16A11 is Present in Offspring of Mothers with Gestational Diabetes. Sevilla-Domingo M, et al. Arch Med Res, 2022 Jul. PMID 35831226
  2. Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population. Mardones L, et al. Arch Endocrinol Metab, 2021 Nov 3. PMID 33909378, Free PMC Article
  3. The association between SLC16A11 haplotype and lipid metabolism in Japanese patients with type 2 diabetes. Kimura Y, et al. Drug Metab Pharmacokinet, 2021 Apr. PMID 33561739
  4. Associations between SLC16A11 variants and diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Hidalgo BA, et al. Sci Rep, 2019 Jan 29. PMID 30696834, Free PMC Article
  5. The SLC16A11 risk haplotype is associated with decreased insulin action, higher transaminases and large-size adipocytes. Almeda-Valdes P, et al. Eur J Endocrinol, 2019 Feb 1. PMID 30475225

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of SLC16A11 is Present in Offspring of Mothers with Gestational Diabetes.
    Title: Downregulation of SLC16A11 is Present in Offspring of Mothers with Gestational Diabetes.
  2. Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population.
    Title: Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population.
  3. The association between SLC16A11 haplotype and lipid metabolism in Japanese patients with type 2 diabetes.
    Title: The association between SLC16A11 haplotype and lipid metabolism in Japanese patients with type 2 diabetes.
  4. Mouse model carrying the reconstituted T2D risk haplotype of human SLC16A11 displays elevated blood and liver triglycerides, glucose intolerance, insulin resistance, and increased levels of lipin 1 protein in the liver in response to a high-fat diet. Human LPIN1 levels are increased in HepG2 cells overexpressing the mutant SLC16A11.
    Title: Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes.
  5. The T2D risk haplotype in the SLC16A11 region includes a cis-eQTL that decreases SLC16A11 expression in a dose-dependent manner in liver tissue.
    Title: Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.
  6. Mouse model carrying the reconstituted T2D risk haplotype of SLC16A11 displays elevated blood and liver triglycerides, glucose intolerance, insulin resistance, and increased levels of lipin 1 protein in the liver in response to a high-fat diet. Human LPIN1 levels are increased in HepG2 cells overexpressing the mutant SLC16A11.
    Title: Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes.
  7. The previously reported effects of SLC16A11 variants shown to be associated with diabetes in Mexicans was replicated in a large Mexican-American sample, but these effects were not significant in five non-Mexican Hispanic/Latino groups sampled from U.S. populations.
    Title: Associations between SLC16A11 variants and diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
  8. Individuals carrying the SLC16A11 risk haplotype exhibited decreased insulin action. Higher serum ALT and GGT levels were found in carriers with type 2 diabetes, and larger adipocytes in subcutaneous fat in the size distribution in carrier women with normal weight.
    Title: The SLC16A11 risk haplotype is associated with decreased insulin action, higher transaminases and large-size adipocytes.
  9. rs13342232 might be involved in the risk of pediatric-onset type 2 diabetes in Mexican families
    Title: Associations of common variants in the SLC16A11, TCF7L2, and ABCA1 genes with pediatric-onset type 2 diabetes and related glycemic traits in families: A case-control and case-parent trio study.
  10. Study demonstrates that disruption of SLC16A11 in primary human hepatocytes leads to Type 2 diabetes (T2D)-relevant changes in fatty acid and lipid metabolism; these results implicate reduced SLC16A11 function in liver as a causal factor for T2D.
    Title: Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ90193

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyruvate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyruvate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
monocarboxylate transporter 11
Names
monocarboxylic acid transporter 11
solute carrier family 16 (monocarboxylic acid transporters), member 11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370549.1 → NP_001357478.1  monocarboxylate transporter 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC040977
    Consensus CDS
    CCDS11086.2
    UniProtKB/Swiss-Prot
    Q8NCK7
    UniProtKB/TrEMBL
    A0A590UJX4, I3L431
    Related
    ENSP00000460927.2, ENST00000574600.3
    Conserved Domains (1) summary
    cl28910
    Location:14 → 403
    MFS; Major Facilitator Superfamily

  2. NM_001370553.1 → NP_001357482.1  monocarboxylate transporter 11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC040977
    Consensus CDS
    CCDS92241.1
    UniProtKB/TrEMBL
    A0A669KBK5
    Related
    ENSP00000501313.1, ENST00000673828.2
    Conserved Domains (1) summary
    cl28910
    Location:14 → 372
    MFS; Major Facilitator Superfamily

  3. NM_153357.3 → NP_699188.2  monocarboxylate transporter 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC040977
    Consensus CDS
    CCDS11086.2
    UniProtKB/Swiss-Prot
    Q8NCK7
    UniProtKB/TrEMBL
    A0A590UJX4, I3L431
    Related
    ENSP00000499634.1, ENST00000662352.3
    Conserved Domains (1) summary
    cl28910
    Location:14 → 403
    MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7041621..7044092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    6942295..6944766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NCK7.1 GenPept UniProtKB/Swiss-Prot:Q8NCK7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous