U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Impact impact, RWD domain protein [ Mus musculus (house mouse) ]

Gene ID: 16210, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Impactprovided by MGI
Official Full Name
impact, RWD domain proteinprovided by MGI
Primary source
MGI:MGI:1098233
See related
Ensembl:ENSMUSG00000024423 AllianceGenome:MGI:1098233
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E430016J11Rik
Summary
Enables actin binding activity and ribosome binding activity. Involved in several processes, including GCN2-mediated signaling; cellular response to starvation; and negative regulation of nitrogen compound metabolic process. Acts upstream of or within negative regulation of protein phosphorylation and regulation of translational initiation. Part of polysome. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human IMPACT (impact RWD domain protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 16.8), cerebellum adult (RPKM 14.5) and 23 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
18 A1; 18 6.87 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (13087747..13126007)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (12954690..12992950)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 1A Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:12966807-12966996 Neighboring gene predicted gene, 36439 Neighboring gene STARR-seq mESC enhancer starr_43844 Neighboring gene STARR-seq mESC enhancer starr_43846 Neighboring gene STARR-seq mESC enhancer starr_43847 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9448 Neighboring gene histamine receptor H4 Neighboring gene ribosomal protein SA pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control. Pereira CM, et al. PLoS One, 2019. PMID 31166980, Free PMC Article
  2. Human homolog of the mouse imprinted gene Impact resides at the pericentric region of chromosome 18 within the critical region for bipolar affective disorder. Kosaki K, et al. Mol Psychiatry, 2001 Jan. PMID 11244491
  3. Comparative genome analysis of the mouse imprinted gene impact and its nonimprinted human homolog IMPACT: toward the structural basis for species-specific imprinting. Okamura K, et al. Genome Res, 2000 Dec. PMID 11116084
  4. An evolutionary scenario for genomic imprinting of Impact lying between nonimprinted neighbors. Okamura K, et al. DNA Res, 2004 Dec 31. PMID 15871461
  5. Screening for imprinted genes by allelic message display: identification of a paternally expressed gene impact on mouse chromosome 18. Hagiwara Y, et al. Proc Natl Acad Sci U S A, 1997 Aug 19. PMID 9256468, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results indicate that IMPACT contributes to GCN2-dependent and -independent mechanisms involved in the regulation of autonomic functions in response to energy availability.
    Title: The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control.
  2. This study extends our understanding of the roles played by GCN1 in GCN2 activation induced by a variety of stress arrangements and suggests that IMPACT and YIH1 use similar mechanisms for regulating this eIF2alpha kinase.
    Title: Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.
  3. the participation of the GCN2-IMPACT module of translational regulation in a highly controlled step in the development of the nervous system.
    Title: IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth.
  4. segmental duplication followed by enhancement of the promoter activity is responsible for the species-specific imprinting of Impact
    Title: An evolutionary scenario for genomic imprinting of Impact lying between nonimprinted neighbors.
  5. IMPACT ensures constant high levels of translation and low levels of CREB-2 and GADD53 in specific neuronal cells under amino acid starvation conditions.
    Title: IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein sequestering activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in GCN2-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GCN2-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to amino acid starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytoplasmic translational initiation in response to stress IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein IMPACT
Names
imprinted and ancient gene protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357396.1 → NP_001344325.1  protein IMPACT isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131672, BM899561
    Conserved Domains (2) summary
    smart00591
    Location:1 → 97
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam01205
    Location:164 → 270
    UPF0029; Uncharacterized protein family UPF0029

  2. NM_008378.3 → NP_032404.1  protein IMPACT isoform 1

    See identical proteins and their annotated locations for NP_032404.1

    Status: VALIDATED

    Source sequence(s)
    AC131672, AK138136, BM899561, CJ056911
    Consensus CDS
    CCDS29068.1
    UniProtKB/Swiss-Prot
    O55091, Q3UUR6, Q9EQH0
    Related
    ENSMUSP00000025290.6, ENSMUST00000025290.7
    Conserved Domains (2) summary
    smart00591
    Location:15 → 115
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam01205
    Location:181 → 288
    UPF0029; Uncharacterized protein family UPF0029

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    13087747..13126007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246850.3 → XP_011245152.1  protein IMPACT isoform X1

    See identical proteins and their annotated locations for XP_011245152.1

    Conserved Domains (2) summary
    smart00591
    Location:1 → 97
    RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
    pfam01205
    Location:164 → 270
    UPF0029; Uncharacterized protein family UPF0029

RNA

  1. XR_001782344.3 RNA Sequence

  2. XR_004939837.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55091.2 GenPept UniProtKB/Swiss-Prot:O55091

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous